Inhibitory effects of intestinal electrical stimulation on food intake, weight loss and gastric emptying in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 293, Issue 1, 2007, Pages

  Yin, Jieyun ^a   Zhang, Jing ^a   Chen, Jiande D Z ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Diet induced obese rats; Gastrointestinal motility; Mechanism; Obesity; Stimulation parameter

Indexed keywords

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ELECTROSTIMULATION; FOOD INTAKE; INTESTINE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; STOMACH EMPTYING; WEIGHT CHANGE; WEIGHT REDUCTION;

ANIMALS; DIET; EATING; ELECTRIC STIMULATION THERAPY; GASTRIC EMPTYING; INTESTINES; MALE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; WEIGHT LOSS;

EID: 34447629008     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00318.2006     Document Type: Article

References (29)

1. American Association of Clinical Endocrinologist/American College of Endocrinology. Position Statement on the Prevention, diagnosis, and treatment of obesity. Endocr Prac 4: 297-330, 1998.
2. Bray GA, Greenway FL. Current and potential drugs for treatment of obesity. Endocr Rev 20: 805-875, 1999.
3. Chen JDZ, Lin HC. Electrical pacing accelerates intestinal transit slowed by fat-induced ileal brake. Dig Dis Sci 48 : 251-256, 2003.
4. Cigaina V, Rigo V, Greenstain RJ. Gastric myo-electrical pacing as therapy for morbid obesity: preliminary results. Obes Surg 6: 250-253, 1999.
5. Cigaina V, Saggioro A, Rigo V, Pinato GP, Ischia S. Long-term effects of gastric pacing to reduce feed intake in swine. Obes Surg 6: 250-253, 1996.
6. Cranley B, Kelly KA, Go VLW, McNichols LA. Enhancing the antidumping effect of roux gastrojejunostomy with intestinal pacing. Ann Surg 198: 516-524, 1983.
7. Favretti F, Luca MD, Segato G, Busetto L, Ceoloni A, Magon A, Enzi G. Treatment of morbid obesity with the Transcend implantable gastric stimulator (I.G.S.). A prospective survey. Obes Surg 14: 666-670, 2004.
8. Kelly KA, Code CF. Duodenal -gastric reflux, and slowed gastric emptying by electrical pacing of the canine duodenal pacesetter potentials. Gastroenterology 72: 429-433, 1977.
9. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL. Increasing prevalence of overweight among US adults: the National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA 272: 205-211, 1994.
10. Levin BE, Dunn-Meynell AA. Dysregulation of arcuate nucleus preproneuropeptide Y. mRNA in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 272: R1365-R1370, 1997.
11. Lin XM, Peters LJ, Hayes J, Chen JDZ. Entrainment of segmental small intestinal slow waves with electrical stimulation in dogs. Dig Dis Sci 45: 652-656, 2000.
12. Liu JS, Qiao X, Zha H, Song GQ, Hou XH, Chen JDZ. Therapeutic potential of intestinal pacing for obesity: reduced fat abforption, and its mechanisms (Abstract). Gastroenterology 128: A416, 2005.
13. Liu S, Hou XH, Chen JDZ. Therapeutic potential of duodenal electrical stimulation for obesity: acute effects on gastric emptying, and water intake. Am J Gastroenterol 100: 792-796, 2005.
14. Miedema BW, Kelly KA. The roux stasis syndrome: treatment by pacing, and prevention by use of an "uncut" roux limb. Arch Surg 127: 295-300, 1992.
15. Ouyang H, Yin J, Chen JD. Therapeutic potential of gastric electrical stimulation for obesity, and its possible mechanisms: a preliminary canine study. Dig Dis Sci 48: 698-705, 2003.
16. Ouyang H, Yin J, Chen JDZ. Gastric or intestinal electrical stimulation-induced increase in gastric volume is correlated with reduced food intake. Scand J Gastroenterol 41: 1261-1266, 2006.
17. Park MI, Camilleri M. Gastric motor and sensory function in obesity. Obes Res 13: 491-500, 2005.
18. Reiser SB, Schusdziarra V, Bollschweiller E, Hölscher AH, Siewert JR. Effect of enteric pacing on intestinal motility, and hormone secretion in dogs with short bowel. Gastroenterology 101: 100-106, 1991.
19. Sagar PM. Surgical treatment of morbid obesity. Br J Surg 82: 732-739, 1995.
20. Sarr MG, Kelly KA, Gladen HE. Electrical control of canine jejunal propulsion. Am J Physiol 240: G355-G360, 1981.
21. Schwartz MW, Woods SC, Porte D, Seeley Jr RJ, Baskin DG: Central nervous system control of food intake. Nature 404: 661-671, 2000.
22. Sun Y, Chen JD. Intestinal electrical stimulation decreases fat absorption in rats: Therapeutic potential for obesity. Obes Res 12: 1235-1242, 2004.
23. Sun Y, Qin C, Foreman RD, Chen JD. Intestinal electric stimulation modulates neuronal activity in the nucleus of the solitary tract in rats. Neurosci Lett 385: 64-69, 2005.
24. Wisen O, Johansson C. Gastrointestinal function in obesity: motility, secretion, and absorption following a liquid test meal. Metabolism 41: 390-395, 1992.
25. Wright RA, Krinsky S, Fleeman C, Trujillo J, Teague E. Gastric emptying and obesity. Gastroenterology 84: 747-751, 1983.
26. Yin J, Chen JDZ. Retrograde gastric electrical stimulation reduces food intake, and weight in obese rats. Obes Res 13: 1580-1587, 2005.
27. Yin J, Ouyang H, Chen JDZ. Potential of intestinal electrical stimulation for obesity: a preliminary canine study. Obesity. In press.
28. Zhang J, Chen JDZ. Central neuronal mechanisms of gastric electrical stimulation, and alterations in central neuronal activities in obese rats (Abstract). Neurogastroenterol Motil 18: 668, 2006.
29. Zhang J, Chen JDZ. Central neuronal mechanism of intestinal electrical stimulation: effects on duodenum distention-responsive (D.D-R) neurons in the VMH of rats (Abstract). Gastroenterology 130: M2256, 2006.