Synthesis and evaluation of water-soluble docetaxel prodrugs-docetaxel esters of malic acid

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 18, 2007, Pages 6323-6330

  Du, Wenting ^a   Hong, Lan ^a   Yao, Tongwei ^a   Yang, Xiaochun ^a   He, Qiaojun ^a   Yang, Bo ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Docetaxel; Malic acid; Paclitaxel; Prodrug; Water soluble

Indexed keywords

2' MALYLDOCETAXEL; DITERPENOID; DOCETAXEL; DOCETAXEL ESTER; MALIC ACID; MALIC ACID DERIVATIVE; PACLITAXEL; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GRAFT; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PLASMA;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MAGNETIC RESONANCE SPECTROSCOPY; MALATES; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED ICR; PLASMA; PRODRUGS; SOLUBILITY; TAXOIDS; TUMOR CELLS, CULTURED; WATER;

EID: 34447627701     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.04.002     Document Type: Article

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