Metabolic protein patterns and monascorubrin production revealed through proteomic approach for Monascus pilosus treated with cycloheximide

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 14, 2007, Pages 5559-5568

  Lin, Wun Yuan ^a   Chang, Jui Yun ^a   Tsai, Pei Ching ^a   Pan, Tzu Ming ^b  

^a SHIH CHIEN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Cycloheximide; Food pigments; Monascus pilosus; Proteome

Indexed keywords

CYCLOHEXIMIDE; FUNGAL PROTEIN; FUSED HETEROCYCLIC RINGS; MONASCORUBRIN; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; DRUG EFFECT; FERMENTATION; GROWTH, DEVELOPMENT AND AGING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MONASCUS; PROTEOMICS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

CHROMATOGRAPHY, LIQUID; CYCLOHEXIMIDE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FERMENTATION; FUNGAL PROTEINS; HETEROCYCLIC COMPOUNDS, 3-RING; MONASCUS; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

MONASCUS; MONASCUS PILOSUS;

EID: 34447622860     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf070162f     Document Type: Article

References (57)

1. Cicero, A. F.; Brancaleoni, M.; Laghi, L.; Donati, F.; Mino, M. Antihyperlipidaemic effect of a Monascus purpureus brand dietary supplement on a large sample of subjects at low risk for cardiovascular disease: a pilot study. Complement Ther. Med. 2005, 13, 273-278.
2. Lin, W. Y.; Song, C. Y.; Pan, T. M. Proteomic analysis of Caco-2 cells treated with monacolin K. J. Agric. Food Chem. 2006, 54, 6192-6200.
3. Hajjaj, H.; Klaebe, A.; Loret, M. O.; Tzedakis, T.; Goma, G.; Blanc, P. J. Production and identification of N-glucosylrubropunctamine and N-glucosylmonascorubramine from Monascus ruber and occurrence of electron donor-acceptor complexes in these red pigments. Appl. Environ. Microbiol. 1997, 63, 2671-2678.
4. Liu, B. H.; Wu, T. S.; Su, M. C.; Chung, C. P.; Yu, F. Y. Evaluation of citrinin occurrence and cytotoxicity in Monascus fermentation products. J. Agric. Food Chem. 2005, 53, 170-175.
5. Hajjaj, H.; Klaebe, A.; Loret, M. O.; Goma, G.; Blanc, P. J.; Francois, J. Biosynthetic pathway of citrinin in the filamentous fungus Monascus ruber as revealed by 13C nuclear magnetic resonance. Appl. Environ. Microbiol. 1999, 65, 311-314.
6. Shimizu, T.; Kinoshita, H.; Ishihara, S.; Sakai, K.; Nagai, S.; Nihira, T. Polyketide synthase gene responsible for citrinin biosynthesis in Monascus purpureus. Appl. Environ. Microbiol. 2005, 71, 3453-3457.
7. Kennedy, J.; Auclair, K.; Kendrew, S. G.; Park, C.; Vederas, J. C.; Hutchinson, C. R. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 1999, 284, 1368-1372.
8. Fischbach, M. A.; Walsh, C. T. Biochemistry directing biosynthesis. Science 2006, 314, 603-605.
9. Hofmann, G.; McIntyre, M.; Nielsen, J. Fungal genomics beyond Saccharomyces cerevisiae? Curr. Opin. Biotechnol. 2003, 14, 226-231.
10. Fujiki, M.; Verner, K. Coupling of protein synthesis and mitochondrial import in a homologous yeast in vitro system. J. Biol. Chem. 1991, 266, 6841-6847.
11. Lin, W. Y.; Ting, Y. C.; Pan, T. M. Proteomic response to intracellular proteins of Monascus pilosus grown under phosphate-limited complex medium with different growth rates and pigment production. J. Agric. Food Chem. 2007, 55, 467-474.
12. Teng, S. S.; Feldheim, W. Anka and anka pigment production. J. Ind. Microbiol. Biotechnol. 2001, 26, 280-282.
13. Sastry, K. V.; Moudgal, R. P.; Mohan, J.; Tyagi, J. S.; Rao, G. S. Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal. Biochem. 2002, 306, 79-82.
14. Grinyer, J.; McKay, M.; Herbert, B.; Nevalainen, H. Fungal proteomics: Mapping the mitochondrial proteins of a Trichoderma harzianum strain applied for biological control. Curr. Genet. 2004, 45, 170-175.
15. Weinert, T. A.; Hartwell, L. H. Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage. Mol. Cell. Biol. 1990, 10, 6554-6564.
16. Kaiwai, S.; Murao, S.; Mochizuki, M.; Shibuya, I.; Yano, K.; Taikagi, M. Drastic alteration of cycloheximide sensitivity by substitution of one amino acid in the L41 ribosomal protein of yeasts. J. Bacteriol. 1992, 174, 254-262.
17. Wilkins, M. R.; Williams, K. L. Cross-species protein identification using amino acid composition, peptide mass fingerprinting, isoelectric point and molecular mass: a theoretical evaluation. J. Theor. Biol. 1997, 186, 7-15.
18. Fechter, P.; Rudinger-Thirion, J.; Tukalo, M.; Giege, R. Major tyrosine identity determinants in Methanococcus jannaschii and Saccharomyces cerevisiae tRNA(Tyr) are conserved but expressed differently. Eur. J. Biochem. 2001, 268, 761-767.
19. Zuniga, M.; Perez, G.; Gonzalez-Candelas, F. Evolution of arginine deiminase (ADI) pathway genes. Mol. Phylogenet. Evol. 2002, 25, 429-444.
20. Crabeel, M.; Lavalle, R.; Glansdorff, N. Arginine-specific repression in Saccharomyces cerevisiae: Kinetic data on ARG1 and ARG3 mRNA transcription and stability support a transcriptional control mechanism. Mol. Cell. Biol. 1990, 10, 1226-1233.
21. Thomas, D.; Surdin-Kerjan, Y. Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 1997, 61, 503-532.
22. Johannesen, P. F.; Hansen, J. Differential transcriptional regulation of sulfur assimilation gene homologues in the Saccharomyces carlsbergensis yeast species hybrid. FEMS Yeast Res. 2002, 1, 315-322.
23. Zhao, Z.; Chen, H.; Li, K.; Du, W.; He, S.; Liu, H. W. Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1- carboxylate deaminase: analysis and mechanistic implications. Biochemistry 2003, 42, 2089-2103.
24. Yao, M.; Ose, T.; Sugimoto, H.; Horiuchi, A.; Nakagawa, A.; Wakatsuki, S.; Yokoi, D.; Murakami, T.; Honma, M.; Tanaka, I. Crystal structure of 1-aminocyclopropane-1-carboxylate deaminase from Hansenula saturnus. J. Biol. Chem. 2000, 275, 34557-34565.
25. Rose, R. B.; Pullen, K. E.; Bayle, J. H.; Crabtree, G. R.; Alber, T. Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2. Biochemistry 2004, 43, 7345-7355.
26. + genes are required for spore wall maturation in Schizosaccharomyces pombe. Genes Cells 2003, 8, 547-558.
27. Pey, A. L.; Martinez, A.; Charubala, R.; Maitland, D. J.; Teigen, K.; Calvo, A.; Pfleiderer, W.; Wood, J. M.; Schallreuter, K. U. Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: Implications for understanding primapterinuria and vitiligo. FASEB J. 2006, 20, 2130-2132.
28. Burke, D. J.; Church, D. Protein synthesis requirements for nuclear division, cytokinesis, and cell separation in Saccharomyces cerevisiae. Mol. Cell. Biol. 1991, 11, 3691-3698.
29. Grundy, F. J.; Henkin, T. M. tRNA as a positive regulator of transcription antitermination in B. subtilis. Cell 1993, 74, 475-482.
30. Grundy, F. J.; Henkin, T. M. Conservation of a transcription antitermination mechanism in aminoacyl-tRNA synthetase and amino acid biosynthesis genes in gram-positive bacteria. J. Mol. Biol. 1994, 235, 798-804.
31. Comer, M. M.; Dondon, J.; Graffe, M.; Yarchuk, O.; Springer, M. Growth rate-dependent control, feedback regulation and steady-state mRNA levels of the threonyl-tRNA synthetase gene of Escherichia coli. J. Mol. Biol. 1996, 261, 108-124.
32. Maloy, S.; Stewart, V. Autogenous regulation of gene expression. J. Bacteriol. 1993, 175, 307-316.
33. Frugier, M.; Ryckelynck, M.; Giege, R. tRNA-balanced expression of a eukaryal aminoacyl-tRNA synthetase by an mRNA-mediated pathway. EMBO Rep. 2005, 6, 860-865.
34. Wang, L. W.; Marzluf, G. A. Nitrogen regulation of uricase synthesis in Neurospora crassa. Mol. Gen. Genet. 1979, 176, 385-392.
35. Geerlof, A.; Travers, F.; Barman, T.; Lionne, C. Perturbation of yeast 3-phosphoglycerate kinase reaction mixtures with ADP: Transient kinetics of formation of ATP from bound 1,3-bisphosphoglycerate. Biochemistry 2005, 44, 14948-14955.
36. Myre, M. A.; O'Day, D. H. Calmodulin binds to and inhibits the activity of phosphoglycerate kinase. Biochim. Biophys. Acta 2004, 1693, 177-183.
37. Gautan, N. Mutated forms of phosphoglycerate mutase in yeast affect reversal of metabolic flux. Effect of reversible and irreversible function of an enzyme on pathway reversal. J. Biol. Chem. 1988, 263, 15400-15406.
38. Chen, Y.; Tye, B. K. The yeast Mcm1 protein is regulated posttranscriptionally by the flux of glycolysis. Mol. Cell. Biol. 1995, 15, 4631-4639.
39. Rodeheffer, M. S.; Shadel, G. S. Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. J. Biol. Chem. 2003, 278, 18695-18701.
40. Erie, D. A. The many conformational states of RNA polymerase elongation complexes and their roles in the regulation of transcription. Biochim. Biophys. Acta 2002, 1577, 224-239.
41. Lee, G. C.; Tang, S. J.; Sun, K. H.; Shaw, J. F. Analysis of the gene family encoding lipases in Candida rugosa by competitive reverse transcription-PCR. Appl. Environ. Microbiol. 1999, 65, 3888-3895.
42. Caldon, C. E.; Yoong, P.; March, P. E. Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function. Mol. Microbiol. 2001, 41, 289-297.
43. Willemoes, M.; Hove-Jensen, B. Binding of divalent magnesium by Escherichia coli phosphoribosyl diphosphate synthetase. Biochemistry 1997, 36, 5078-5083.
44. + sensitivity. Biochem. Soc. Trans. 2005, 33, 1154-1157.
45. Eriksen, T. A.; Kadziola, A.; Larsen, S. Binding of cations in Bacillus subtilis phosphoribosyldiphosphate synthetase and their role in catalysis. Protein Sci. 2002, 11, 271-279.
46. Kalivoda, K. A.; Steenbergen, S. M.; Vimr, E. R.; Plumbridge, J. Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. J. Bacteriol. 2003, 185, 4806-4815.
47. Rigali, S.; Derouaux, A.; Giannotta, F.; Dusart, J. Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies. J. Biol. Chem. 2002, 277, 12507-12515.
48. Charlier, D.; Kholti, A.; Huysveld, N.; Gigot, D.; Maes, D.; Thia-Toong, T. L.; Glansdorff, N. Mutational analysis of Escherichia coli PepA, a multifunctional DNA-binding aminopeptidase. J. Mol. Biol. 2000, 302, 411-426.
49. Mathew, Z.; Knox, T. M.; Miller, C. G. Salmonella enterica serovar typhimurium peptidase B is a leucyl aminopeptidase with specificity for acidic amino acids. J. Bacteriol. 2000, 182, 3383-3393.
50. Rowen, D. W.; Meinke, M.; LaPorte, D. C. GLC3 and GHA1 of Saccharomyces cerevisiae are allelic and encode the glycogen branching enzyme. Mol. Cell. Biol. 1992, 12, 22-29.
51. Wilson, W. A.; Hughes, W. E.; Tomamichel, W.; Roach, P. J. Increased glycogen storage in yeast results in less branched glycogen. Biochem. Biophys. Res. Commun. 2004, 320, 416-423.
52. Chen, L. M.; Li, K. Z.; Miwa, T.; Izui, K. Overexpression of a cyanobacterial phosphoenolpyruvate carboxylase with diminished sensitivity to feedback inhibition in Arabidopsis changes amino acid metabolism. Planta 2004, 219, 440-449.
53. Ling, H.; Vadali, R. V.; Bennett, G. N.; San, K. Y. Increasing the acetyl-CoA pool in the presence of overexpressed phosphoenolpyruvate carboxylase or pyruvate carboxylase enhances succinate production in Escherichia coli. Biotechnol. Prog. 2004, 20, 1599-1604.
54. Vienken, K.; Scherer, M.; Fischer, R. The Zn(II)2Cys6 putative Aspergillus nidulans transcription factor repressor of sexual development inhibits sexual development under low-carbon conditions and in submersed culture. Genetics 2005, 169, 619-630.
55. Ross, K. L.; Davis, C. N.; Fridovich-Keil, J. L. Differential roles of the Leloir pathway enzymes and metabolites in defining galactose sensitivity in yeast. Mol. Genet. Metab. 2004, 83, 103-116.
56. Klar, A. J.; Cohen, A.; Halvorson, H. O. Control of enzyme synthesis and stability during sporulation in Saccharomyces cerevisiae. Biochimie 1976, 58, 219-224.
57. Takagi, M.; Kawai, S.; Shibuya, I.; Miyazaki, M.; Yano, K. Cloning in Saccharomyces cerevisiae of a cycloheximide resistance gene from the Candida maltosa genome which modifies ribosomes. J. Bacteriol. 1986, 168, 417-419.