Lack of dynamics in the MabA active site kills the enzyme activity: Practical consequences for drug-design studies

Acta Crystallographica Section D: Biological Crystallography

Volumn 63, Issue 8, 2007, Pages 923-925

  Poncet Montange, Guillaume ^a,b,c   Ducasse Cabanot, Stephanie ^d   Quemard, Annaick ^d   Labesse, Gilles ^a,b,c   Cohen Gonsaud, Martin ^a,b,c  

^a CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^b INSERM   (France)

^c UNIV MONTPELLIER   (France)

^d INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

ketoacyl reductase; Conformational change; FabG1; Inactivation

Indexed keywords

3 OXOACYL (ACYL CARRIER PROTEIN) REDUCTASE; 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE; ALCOHOL DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ALCOHOL OXIDOREDUCTASES; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MODELS, MOLECULAR; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, TERTIARY;

MYCOBACTERIUM TUBERCULOSIS;

EID: 34447622332     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444907024158     Document Type: Article

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