Evidence of Na current contribution to the transient outward current in cardiac ventricular myocytes

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 1, Issue 2, 1996, Pages 149-158

  Boutjdir, Mohamed ^a   Zhang, Zhi Hao ^a   Huang, Boyu ^a   Chen, Long ^a   Stergiopoulos, Nicholas ^a   El Sherif, Nabil ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

4 aminopyridine; Potassium channels; Sea anemone toxin; Tetrodotoxin

Indexed keywords

EID: 34447621687     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/107424849600100209     Document Type: Article

References (26)

1. Dukes ID, Morad M. The transient outward current in rat ventricular myocytes: Evaluation of its Ca and Na dependence. J Physiol 435:395, 1991.
2. Mansourati J, Le Grand B. Transient outward current in young and diseased human atria. Am J Physiol 265:H1466, 1993.
3. Nabauer M, Beuckelmann DJ, Erdmann E. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 73:386, 1993.
4. Tohse N, Nakaya H, Hattori Y, Endo M, Kanno M. Inhibitory effect mediated by α1-adrenoreceptors on transient outward current in isolated rat ventricular cells. Pflugers Arch 415:575, 1990.
5. Tomita F, Basset A, Myerbutg RJ, Kimura S. Diminished transient outward currents in rat hypertrophied ventricular myocytes. Circ Res 75:296, 1993.
6. Fermini B. Nattel S. Choline chloride activates time-dependent K current in dog atrial myocytes. Am J Physiol 266:C42, 1994.
7. Apkon M, Nerbonne JM. Characterization of two distinct depolarization-activated K currents in isolated adult rat ventricular myocytes. J Gen Physiol 97:973, 1991.
8. Tseng GN, Hoffman BF. Two components of transient outward current in canine ventricular myocytes. Circ Res 64:633, 1989.
9. Zhang ZH, Boutjdir M, El-Sherif N. Ketanserin inhibits depolarization-activated outward potassium current in rat ventricular myocytes. Circ Res 75:711, 1993.
10. Escande D, Coulombe A, Faivre JF, Deroubaix E, Coraboeuf E. Two types of transient outward currents in adult human atrial cells. Am J Physiol 252:H142, 1985.
11. Fermini B, Duan DY, Nattel S. Differences in the rate dependence of the transient outward current in rabbit and human atrium. Am J Physiol 263:H1747, 1992.
12. Shibata EF, Drury I, Refsum H, Aldrete V, Giles W. Contributions of a transient outward current to repolarization in human atrium. Am J Physiol 257:H1773, 1989.
13. Wittenberg BA, White RL, Ginzberg RD, Spray D. Effect of calcium on the dissociation of the mature rat heart into individual and paired myocytes: Electrical properties of cell pairs. Circ Res 59:143., 1986.
14. Scamps F, Legssyer A, Mayoux E, Vassort G. The mechanism of positive inotropy induced by ATP in rat heart. Circ Res 67:1007, 1990.
15. Boutjdir M, Mery PF, Hanf R, Fischmeister R. High affinity forskolin inhibition of L-type Ca2+ current in cardiac cells. Mol Pharmacol 38:758, 1990.
16. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cell and cell-free membrane patches. Pflügers Arch 391:85, 1981.
17. toI, inactivation in rabbit atrial myocytes is a novel Cl current. Am J Physiol 263:H1967, 1992.
18. Craelius W, Green W, Wu KM. Persistent sodium currents induced by anthopleurin-A and their relationship to early afterdepolarizations in ventricular myocytes. Arch Int Pharmaco 324:60, 1993.
19. El Sherif N, Fozzard HA, Hanck DA. Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII. Circ Res 70:285, 1992.
20. Hank DA, Sheets MF. Modification of inactivation in cardiac Na channels: Ionic current studies with anthopleurin-A toxin. J Gen Physiol 106:601, 1995.
21. Lefevre IA, Coulombe A, Coraboeuf E. The calcium antagonist D600 inhibits calcium-independent transient outward current in isolated rat ventricular myocytes. J Physiol 432:65, 1991.
22. Sheu SS, Fozzard H. Transmembrane Na and Ca electrochemical gradients in cardiac muscle and their relationship to force development. J Gen Physiol 30:325, 1982.
23. Badder CR, Bernheim L, Bertrand D. Na-activated K current in cultured avian neurones. Nature 317:530, 1985.
24. Isenberg G, Ravens U. The effects of the ammonia sulcata toxin (ATXII) on membrane currents of isolated mammalian myocytes. J Physiol 357:127, 1984.
25. Schreibmayer W, Kazerani H, Tritthart HA. A mechanistic interpretation of the action of toxin II from anernonia sulcata on the cardiac sodium channel. Biochim Biophys Acta 901:273, 1987.
26. Catterall WA. Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72:S15, 1992.