Firing dynamics of cerebellar Purkinje cells

Journal of Neurophysiology

Volumn 98, Issue 1, 2007, Pages 278-294

  Fernandez, Fernando R ^a,b   Engbers, Jordan D T ^a   Turner, Ray W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFTERDISCHARGE; ANIMAL CELL; ARTICLE; BIOPHYSICS; CELL ACTIVITY; CEREBELLUM; CONTROLLED STUDY; DEPOLYMERIZATION; ELECTROPHYSIOLOGY; EXPERIMENTAL MODEL; FREQUENCY MODULATION; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; SPIKE WAVE;

ACTION POTENTIALS; ANESTHETICS, LOCAL; ANIMALS; ANIMALS, NEWBORN; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC CONDUCTIVITY; ELECTRIC STIMULATION; MODELS, NEUROLOGICAL; NONLINEAR DYNAMICS; PATCH-CLAMP TECHNIQUES; PURKINJE CELLS; RATS; RATS, SPRAGUE-DAWLEY; TETRODOTOXIN;

EID: 34447577714     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00306.2007     Document Type: Article

References (54)

1. Cerminara NL, Rawson JA. Evidence that climbing fibers control an intrinsic spike generator in cerebellar Purkinje cells. J Neurosci 24: 4510-4517, 2004.
2. Colin F, Manil J, Desclin JC. The olivocerebellar system. I. Delayed and slow inhibitory effects: an overlooked salient feature of cerebellar climbing fibers. Brain Res 187: 3-27, 1980.
3. Crunelli V, Toth TI, Cope DW, Blethyn K, Hughes SW. The "window" T-type calcium current in brain dynamics of different behavioural states. J Physiol 562: 121-129, 2005.
4. De Schutter E, Bower JM. An active membrane model of the cerebellar Purkinje cell II. Simulation of synaptic responses. J Neurophysiol 71: 401-419, 1994a.
5. De Schutter E, Bower JM. Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs. Proc Natl Acad Sci USA 91: 4736-4740, 1994b.
6. Doiron B, Longtin A, Turner RW, Maler L. Model of gamma frequency burst discharge generated by conditional backpropagation. J Neurophysiol 86: 1523-1545, 2001.
7. Ebner TJ, Bloedel JR. Role of climbing fiber afferent input in determining responsiveness of Purkinje cells to mossy fiber inputs. J Neurophysiol 45: 962-971, 1981.
8. Ebner TJ, Bloedel JR. Climbing fiber action on the responsiveness of Purkinje cells to parallel fiber inputs. Brain Res 309: 182-186, 1984.
9. Ermentrout B. Simulating, Analyzing, and Animating Dynamical Systems: A Guide to XPPAUT for Researchers and Students. Philadelphia, PA: Society for Industrial and Applied Mathematics, 2002.
10. + current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential. J Neurophysiol 94: 3836-3848, 2005.
11. Genet S, Delord B. A biophysical model of nonlinear dynamics underlying plateau potentials and calcium spikes in Purkinje cell dendrites. J Neurophysiol 88: 2430-2444, 2002.
12. Hounsgaard J, Midtgaard J. Intrinsic determinants of firing pattern in Purkinje cells of the turtle cerebellum in vitro. J Physiol 402: 731-749, 1988.
13. Hounsgaard J, Midtgaard J. Synaptic control of excitability in turtle cerebellar Purkinje cells. J Physiol 409: 157-170, 1989.
14. + channel, in migrating Purkinje cells and other post-migratory cerebellar neurons. Eur J Neurosci 18: 601-612, 2003.
15. Hutcheon B, Yarom Y. Resonance, oscillation and the intrinsic frequency preferences of neurons. Trends Neurosci 23: 216-222, 2000.
16. Izhikevich EM. Neural excitability, spiking, and bursting. Int J Bifurc Chaos 10: 1171-1266, 2000.
17. Izhikevich EM. Dynamical Systems in Neuroscience: The Geometry of Excitability and Bursting. Cambridge, MA: MIT Press, 2007.
18. Izhikevich EM, Desai NS, Walcott EC, Hoppensteadt FC. Bursts as a unit of neural information: selective communication via resonance. Trends Neurosci 26: 161-167, 2003.
19. Jaeger D, De Schutter E, Bower JM. The role of synaptic and voltage-gated currents in the control of Purkinje cell spiking: a modeling study. J Neurosci 17: 91-106, 1997.
20. Khaliq ZM, Gouwens NW, Raman IM. The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study. J Neurosci 23: 4899-4912, 2003.
21. Li WC, Soffe SR, Wolf E, Roberts A. Persistent responses to brief stimuli: feedback excitation among brainstem neurons. J Neurosci 26: 4026-4035, 2006.
22. Llinas R, Sugimori M. Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. J Physiol 305: 197-213, 1980a.
23. Llinas R, Sugimori M. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J Physiol 305: 171-195, 1980b.
24. Loewenstein Y, Mahon S, Chadderton P, Kitamura K, Sompolinsky H, Yarom Y, Hausser M. Bistability of cerebellar Purkinje cells modulated by sensory stimulation. Nat Neurosci 8: 202-211, 2005.
25. Mainen ZF, Sejnowski TJ. Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382: 363-366, 1996.
26. Martina M, Metz AE, Bean BP. Voltage-dependent potassium currents during fast spikes of rat cerebellar Purkinje neurons: inhibition by BDS-I toxin. J Neurophysiol 97: 563-571, 2007.
27. Martina M, Yao GL, Bean BP. Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. J Neurosci 23: 5698-5707, 2003.
28. McKay BE, Engbers JD, Mehaffey WH, Gordon GR, Molineux ML, Bains JS, Turner RW. Climbing fiber discharge regulates cerebellar functions by controlling the intrinsic characteristics of Purkinje cell output. J Neurophysiol 97: 2590-2604, 2007.
29. + channels control Purkinje cell output to facilitate postsynaptic rebound discharge in deep cerebellar neurons. J Neurosci 25: 1481-1492, 2005.
30. + channels enable burst output in rat cerebellar Purkinje cells. Eur J Neurosci 20: 729-739, 2004.
31. McKay BE, Turner RW. Physiological and morphological development of the rat cerebellar Purkinje cell. J Physiol 567: 829-850, 2005.
32. Montarolo PG, Palestini M, Strata P. The inhibitory effect of the olivocerebellar input on the cerebellar Purkinje cells in the rat. J Physiol 332: 187-202, 1982.
33. Pinsky PF, Rinzel J. Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 1: 39-60, 1994.
34. Raman IM, Bean BP. Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. J Neurosci 19: 1663-1674, 1999a.
35. Raman IM, Bean BP. Properties of sodium currents and action potential firing in isolated cerebellar Purkinje neurons. Ann NY Acad Sci 868: 93-96, 1999b.
36. Raman IM, Bean BP. Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophys J 80: 729-737, 2001.
37. Rapp M, Segev I, Yarom Y. Physiology, morphology and detailed passive models of guinea-pig cerebellar Purkinje cells. J Physiol 474: 101-118, 1994.
38. Rinzel J. Excitation dynamics: insights from simplified membrane models. Fed Proc 44: 2944-2946, 1985.
39. Rinzel J, Ermentrout B. Analysis of neural excitability and oscillations. In: Methods in Neuronal Modeling, edited by Koch C, Segev I. Cambridge, MA: MIT Press, 1998, p. 251-291.
40. Roth A, Hausser M. Compartmental models of rat cerebellar Purkinje cells based on simultaneous somatic and dendritic patch-clamp recordings. J Physiol 535: 445-472, 2001.
41. Sacco T, Tempia F. A-type potassium currents active at subthreshold potentials in mouse cerebellar Purkinje cells. J Physiol 543: 505-520, 2002.
42. Santamaria F, Bower JM. Background synaptic activity modulates the response of a modeled Purkinje cell to paired afferent input. J Neurophysiol 93: 237-250, 2005.
43. Santamaria F, Jaeger D, De Schutter E, Bower JM. Modulatory effects of parallel fiber and molecular layer interneuron synaptic activity on Purkinje cell responses to ascending segment input: a modeling study. J Comput Neurosci 13: 217-235, 2002.
44. Schmolesky MT, Weber JT, De Zeeuw CI, Hansel C. The making of a complex spike: ionic composition and plasticity. Ann NY Acad Sci 978: 359-390, 2002.
45. Schonewille M, Khosrovani S, Winkelman BH, Hoebeek FE, De Jeu MT, Larsen IM, Van der Burg J, Schmolesky MT, Frens MA, De Zeeuw CI. Purkinje cells in awake behaving animals operate at the upstate membrane potential. Nat Neurosci 9: 459-461, 2006.
46. Seung HS, Lee DD, Reis BY, Tank DW. Stability of the memory of eye position in a recurrent network of conductance-based model neurons. Neuron 26: 259-271, 2000.
47. Stafstrom CE, Schwindt PC, Crill WE. Negative slope conductance due to a persistent subthreshold sodium current in cat neocortical neurons in vitro. Brain Res 236: 221-226, 1982.
48. Strogatz SH. Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry, and Engineering. Reading, MA: Addison-Wesley, 1994.
49. Stuart G, Hausser M. Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron 13: 703-712, 1994.
50. Swensen AM, Bean BP. Ionic mechanisms of burst firing in dissociated Purkinje neurons. J Neurosci 23: 9650-9663, 2003.
51. Vetter P, Roth A, Hausser M. Propagation of action potentials in dendrites depends on dendritic morphology. J Neurophysiol 85: 926-937, 2001.
52. Williams SR, Christensen SR, Stuart GJ, Hausser M. Membrane potential bistability is controlled by the hyperpolarization-activated current I(H) in rat cerebellar Purkinje neurons in vitro. J Physiol 539: 469-483, 2002.
53. 2+ current produces input signal amplification and bistability in cat and rat thalamocortical neurones. J Physiol 505: 689-705, 1997.
54. Womack M, Khodakhah K. Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons. J Neurosci 22: 10603-10612, 2002.