On the structure of maitotoxin

Angewandte Chemie - International Edition

Volumn 46, Issue 28, 2007, Pages 5278-5282

  Nicolaou, K C ^a,b   Frederick, Michael O ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biosynthesis; Density functional calculations; NMR spectroscopy; Stereochemistry; Structure elucidation

Indexed keywords

MAITOTOXIN;

BIOSYNTHESIS; COMPUTATIONAL METHODS; CYTOTOXICITY; DENSITY FUNCTIONAL THEORY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY;

TOXIC MATERIALS;

MAITOTOXIN; MARINE TOXIN; OXOCIN DERIVATIVE;

BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVIEW; STEREOISOMERISM;

MAGNETIC RESONANCE SPECTROSCOPY; MARINE TOXINS; MOLECULAR STRUCTURE; OXOCINS; STEREOISOMERISM;

EID: 34447565953     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200604656     Document Type: Review

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36. A different set of enzymes would most likely be required for the formation of the K, L, and N rings of structure 7 (Scheme 1) in this scenario. Since very little is known about the biosynthesis of maitotoxin and related substances, any suggestions regarding their generation in nature should be considered as mere speculation.