The cost-effectiveness of stem cell transplantations from unrelated donors in adult patients with acute leukemia

Value in Health

Volumn 10, Issue 4, 2007, Pages 247-255

  Costa, Vania ^a   McGregor, Maurice ^a,b   Laneuville, Pierre ^b   Brophy, James M ^a,b,c  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Bone marrow stem cells; Cord blood; Cost effectiveness; Mortality; Peripheral blood stem cells; Stem cell transplantation

Indexed keywords

ACUTE LEUKEMIA; ADULT; ARTICLE; BLOOD DONOR; BONE MARROW TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CONFIDENCE INTERVAL; CORD BLOOD STEM CELL TRANSPLANTATION; COST EFFECTIVENESS ANALYSIS; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MONTE CARLO METHOD; MORTALITY; MULTIVARIATE ANALYSIS; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; SURVIVAL RATE;

EID: 34447552517     PISSN: 10983015     EISSN: 15244733     Source Type: Journal    
DOI: 10.1111/j.1524-4733.2007.00180.x     Document Type: Article

References (52)

1. Ringden O. Allogeneic bone marrow transplantation for hematological malignancies - controversies and recent advances. Acta Oncol 1997 36 : 549 64.
2. Lennard AL, Jackson GH. Stem cell transplantation. BMJ 2000 321 : 433 7.
3. Leger CS, Nevill TJ. Hematopoietic stem cell transplantation: a primer for the primary care physician. CMAJ 2004 170 : 1569 77.
4. Grewal SS, Barker JN, Davies SM, Wagner JE. Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood? Blood 2003 101 : 4233 44.
5. Barker JN, Davies SM, DeFor T, et al. Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood 2001 97 : 2957 61.
6. Barker JN, Wagner JE. Umbilical cord blood transplantation: current state of the art. Curr Opin Oncol 2002 14 : 160 4.
7. Gluckman E, Locatelli F. Umbilical cord blood transplants. Curr Opin Hematol 2000 7 : 353 7.
8. Gluckman E, Koegler G, Rocha V. Human leukocyte antigen matching in cord blood transplantation. Semin Hematol 2005 42 : 85 90.
9. Appelbaum FR. Allogeneic hematopoietic stem cell transplantation for acute leukemia. Semin Oncol 1997 24 : 114 23.
10. Brenner MK. Cecil Textbook of Medicine. Philadelphia : W.B. Saunders, 2000.
11. Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982 5 : 649 55.
12. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-Analysis of Observational Studies in Epidemiology (MOOSE) Group. JAMA 2000 283 : 2008 12.
13. Bahng H, Lee JH, Ahn JH, et al. Combination chemotherapy utilizing continuous infusion of intermediate-dose cytarabine for refractory or recurrent acute myeloid leukemia. Leuk Res 2001 25 : 213 16.
14. Baudard M, Legrand O, Marie JP, Zittoun R. Smoldering acute myelogenous leukemia in the elderly. Leuk Lymphoma 1999 34 : 561 7.
15. Camera A, Annino L, Chiurazzi F, et al. GIMEMA ALL - Rescue 97: a salvage strategy for primary refractory or relapsed adult acute lymphoblastic leukemia. Haematologica 2004 89 : 145 53.
16. Garcia-Manero G, Thomas DA. Salvage therapy for refractory or relapsed acute lymphocytic leukemia. Hematol Oncol Clin North Am 2001 15 : 163 205.
17. Kern W, Schleyer E, Braess J, et al. Efficacy of fludarabine, intermittent sequential high-dose cytosine arabinoside, and mitoxantrone (FIS-HAM) salvage therapy in highly resistant acute leukemias. Ann Hematol 2001 80 : 334 9.
18. Ottmann OG, Druker BJ, Sawyers CL, et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood 2002 100 : 1965 71.
19. Rodrigues CA, Chauffaille ML, Pelloso LA, et al. Acute myeloid leukemia in elderly patients: experience of a single center. Braz J Med Biol Res 2003 36 : 703 8.
20. National Marrow Donor Program. A. Medical Professional Guide to Unrelated Donors Stem Cell Transplantation. Available from: http://www.marrow.org/ MEDICAL/medical_professionals_guide.pdf [Accessed November, 2004].
21. Fung HC, Stein A, Slovak M, et al. A long-term follow-up report on allogeneic stem cell transplantation for patients with primary refractory acute myelogenous leukemia: impact of cytogenetic characteristics on transplantation outcome. Biol Blood Marrow Transplant 2003 9 : 766 71.
22. Kalhs P, Brugger S, Reiter E, et al. Low transplant-related mortality in patients receiving unrelated donor marrow grafts for leukemia. Bone Marrow Transplant 1999 23 : 753 8.
23. Wong R, Shahjahan M, Wang X, et al. Prognostic factors for outcomes of patients with refractory or relapsed acute myelogenous leukemia or myelodysplastic syndromes undergoing allogeneic progenitor cell transplantation. Biol Blood Marrow Transplant 2005 11 : 108 14.
24. Health Canada. Life Tables, Canada, Provinces and Territories 1995-1997. Available from: http://www.statcan.ca:8096/bsolc/english/bsolc?catno=84-537-X [Accessed January, 2005].
25. Frassoni F, Labopin M, Gluckman E, et al. Are patients with acute leukemia, alive and well 2 years post bone marrow transplantation cured? A European survey. Acute Leukemia Working Party of the European Group for Bone Marrow Transplantation (EBMT). Leukemia 1994 8 : 924 8.
26. Couban S, Dranitsaris G, Andreou P, et al. Clinical and economic analysis of allogeneic peripheral blood progenitor cell transplants: a Canadian perspective. Bone Marrow Transplant 1998 22 : 1199 205.
27. Critchfield GC, Willard KE, Connelly DP. Probabilistic sensitivity analysis methods for general decision models. Comput Biomed Res 1986 19 : 254 65.
28. Doubilet P, Begg CB, Weinstein MC, et al. Probabilistic sensitivity analysis using Monte Carlo simulation. A practical approach. Med Decis Making 1985 5 : 157 77.
29. Manning WG, Fryback DG, Weinstein MC. Reflecting uncertainty in cost-effectiveness analysis. In : Gold MR, Siegel JE, Russel LB, Weinstein MC, eds. Cost-Effectiveness in Health and Medicine. New York : Oxford University Press, 1996.
30. Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001 344 : 1815 22.
31. Gluckman E, Rocha V, Chevret S. Results of unrelated umbilical cord blood hematopoietic stem cell transplant. Transfus Clin Biol 2001 8 : 146 54.
32. Long GD, Laughlin M, Madan B, et al. Unrelated umbilical cord blood transplantation in adult patients. Biol Blood Marrow Transplant 2003 9 : 772 80.
33. Stevens Ce C, Scaradavou A, Rubinstein P. Cord blood transplantation to adult patients: a single-bank's experience. Biol Blood Marrow Transplant 2004 10 : 10 733.
34. Rocha V. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004 351 : 2276 85.
35. Laughlin MJ. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004 351 : 2265 75.
36. Cornetta K, Laughlin M, Carter S, et al. Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT). Biol Blood Marrow Transplant 2005 11 : 149 60.
37. Fauser AA, Basara N, Blau IW, Kiehl MG. A comparative study of peripheral blood stem cell vs. bone marrow transplantation from unrelated donors (MUD): a single center study. Bone Marrow Transplant 2000 25 (Suppl. 2 S27 31.
38. Nivison-Smith I, Bradstock KF, Dodds AJ, et al. Haemopoietic stem cell transplantation in Australia and New Zealand, 1992-2001: progress report from the Australasian Bone Marrow Transplant Recipient Registry. Intern Med J 2005 35 : 18 27.
39. Benito AI, Diaz MA, Gonzalez-Vicent M, et al. Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results. Bone Marrow Transplant 2004 33 : 675 90.
40. Lee SJ, Zahrieh D, Alyea EP, et al. Comparison of T-cell-depleted and non-T-cell-depleted unrelated donor transplantation for hematologic diseases: clinical outcomes, quality of life, and costs. Blood 2002 100 : 2697 702.
41. Uyl-de Groot CA. Costs of diagnosis, treatment, and follow up of patients with acute myeloid leukemia in the Netherlands. J Hematother Stem Cell Res 2001 10 : 187 92.
42. Lee SJ, Klar N, Weeks JC, Antin JH. Predicting costs of stem-cell transplantation. J Clin Oncol 2000 18 : 64 71.
43. Jacobs P, Hailey D, Turner R, MacLean N. Allogeneic stem cell transplantation. An economic comparison of bone marrow, peripheral blood, and cord blood technologies. Int J Technol Assess Health Care 2000 16 : 874 84.
44. Bennett C, Waters T, Stinson T, et al. Valuing clinical strategies early in development: a cost analysis of allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant 1999 24 : 555 60.
45. Mishra V, Vaaler S, Brinch L. A prospective cost evaluation related to allogeneic haemopoietic stem cell transplantation including pretransplant procedures, transplantation and 1 year follow-up procedures. Bone Marrow Transplant 2001 28 : 1111 16.
46. van Agthoven M, Groot MT, Verdonck LF, et al. Cost analysis of HLA-identical sibling and voluntary unrelated allogeneic bone marrow and peripheral blood stem cell transplantation in adults with acute myelocytic leukemia or acute lymphoblastic leukemia. Bone Marrow Transplant 2002 30 : 243 51.
47. Waters TM, Bennett CL, Pajeau TS, et al. Economic analyses of bone marrow and blood stem cell transplantation for leukemias and lymphoma: what do we know? Bone Marrow Transplant 1998 21 : 641 50.
48. Alberta Health and Wellness. Health Costing in Alberta - 2003 Annual Report. Available from: http://www.health.gov.ab.ca/resources/publications/pdf/ Health_Costing_2003.pdf [Accessed April 10, 2005].
49. Ballen KK. New trends in umbilical cord blood transplantation. Blood 2005 105 : 3786 92.
50. Greinix HT, Nachbaur D, Krieger O, et al. Factors affecting long-term outcome after allogeneic haematopoietic stem cell transplantation for acute myelogenous leukemia: a retrospective study of 172 adult patients reported to the Austrian Stem Cell Transplantation Registry. Br J Haematol 2002 117 : 914 23.
51. Robin M, Guardiola P, Dombret H, et al. Allogeneic bone marrow transplantation for acute myeloblastic leukemia in remission: risk factors for long-term morbidity and mortality. Bone Marrow Transplant 2003 31 : 877 87.
52. Hamza NS, Lisgaris M, Yadavalli G, et al. Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults. Br J Haematol 2004 124 : 488 98.