Mouse model of the metabolic syndrome: The quest continues

Journal of Applied Physiology

Volumn 102, Issue 6, 2007, Pages 2088-2089

  Polotsky, Vsevolod Y ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HIGH DENSITY LIPOPROTEIN RECEPTOR; INSULIN; LEPTIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL;

ATHEROSCLEROSIS; CALORIC INTAKE; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; DISEASE PREDISPOSITION; EDITORIAL; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HEART INFARCTION; HUMAN; HYPERINSULINEMIA; HYPERTENSION; INSULIN RESISTANCE; LIFESTYLE; METABOLIC SYNDROME X; MORBIDITY; MORTALITY; MOUSE STRAIN; NONHUMAN; OBESITY; PREVALENCE; PRIORITY JOURNAL; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ANIMALS; CHOLESTEROL; DIETARY FATS; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METABOLIC SYNDROME X; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, TRANSGENIC;

EID: 34447549118     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00219.2007     Document Type: Editorial

References (17)

1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287: 356-359, 2002.
2. Hogarth CA, Roy A, Ebert DL. Genomic evidence for the absence of a functional cholesteryl ester transfer protein gene in mice and rats. Comp Biochem Physiol B Biochem Mol Biol 135: 219-229, 2003.
3. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-141, 1997.
4. Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92: 883-893, 1993.
5. Joslin EP. The prevention of diabetes mellitus. JAMA 76: 79-84. 1921.
6. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106: 3143-3421, 2002.
7. Phillips GB. Sex hormones, risk factors and cardiovascular disease. Am J Med 65: 7-11, 1978.
8. Reaven GM. Banting lecture. Role of insulin resistance in human disease. Diabetes 37: 1595-1607, 1988.
9. Rigotti A, Trigatti BL, Penman M, Rayburn H, Herz J, Krieger M. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci USA 94: 12610-12615, 1997.
10. Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 12: 3182-3194, 1998.
11. Svenson KL, Bogue MA, Peters LL. Invited review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains. J Appl Physiol 94: 1650-1659, 2003.
12. Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol; doi: 10:1152/japplphysiol.01077.2006.
13. Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr 4: 20-34, 1956.
14. Williams CM. Lipid metabolism in women. Proc Nutr Soc 63: 153-160, 2004.
15. Zhang SH, Reddick RL, Burkey B, Maeda N. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest 94: 937-945, 1994.
16. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.
17. Zimmet PZ, McCarty DJ, de Court MP. The global epidemiology of non-insulin-dependent diabetes mellitus and the metabolic syndrome. J Diabetes Complications 11: 60-68, 1997.