Is routine molecular screening for common α-thalassaemia deletions necessary as part of an antenatal screening programme?

Journal of Medical Screening

Volumn 14, Issue 2, 2007, Pages 60-61

  Sorour, Y ^a   Heppinstall, S ^a   Porter, N ^a   Wilson, G A ^a   Goodeve, A C ^a   Rees, D ^b   Wright, J ^a  

^a SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALPHA THALASSEMIA; ARTICLE; BETA THALASSEMIA; CONTROLLED STUDY; ETHNIC GROUP; FEMALE; GENE DELETION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MEAN CORPUSCULAR HEMOGLOBIN; POLYMERASE CHAIN REACTION; PRENATAL SCREENING;

ALPHA-THALASSEMIA; ASIA, SOUTHEASTERN; ENGLAND; FEMALE; FETAL DISEASES; GENE DELETION; GENE FREQUENCY; GENETIC SCREENING; GENOTYPE; HEMOGLOBINS; HUMANS; PREGNANCY; PRENATAL DIAGNOSIS;

EID: 34447514361     PISSN: 09691413     EISSN: 14755793     Source Type: Journal    
DOI: 10.1258/096914107781261981     Document Type: Article

References (5)

1. Tan AS, Quah TC, Low PS, Chong SS. A rapid and reliable 7-deletion multiplex polymerase chain reaction assay for α-thalassemia. Blood 2001;98:250-1
2. Liang ST, Wong VCW, So WWK, Ma HK, Chan V, Todd D. Homozygous- thalassaemia: clinical presentation, diagnosis and management. A review of 46 cases. Br J Obstet Gynaec 1985;92:680
3. Tan SL, Tseng AMP, Thong P-W. Bart's hydrops fetalis: clinical presentation and management. An analysis of 25 cases. Aust NZ J Obstet Gynaecol 1989;3:233
4. Ko T-M, Hsieh F-J, Hsu P-M, Lee T-Y. Molecular characterization of severe-thalassemias causing hydrops fetalis in Taiwan. Am J Med Genet 1991;39:317
5. The Thalassaemia Working Party of the BCSH General Haematology Task Force. Guidelines for the laboratory diagnosis of haemoglobinopathies. Brit J Haematol 1998;101:783