A dopamine D4 receptor exon 3 VNTR allele protecting against migraine without aura

Annals of Neurology

Volumn 61, Issue 6, 2007, Pages 574-578

  Campos De Sousa, Sara ^a   Karwautz, Andreas ^b,c   Wöber, Christian ^b   Wagner, Gudrun ^b   Breen, Gerome ^a   Zesch, Heidi Elisabeth ^b   Konrad, Andrea ^b   Zormann, Arno ^b   Wanner, Christian ^b   Kienbacher, Christian ^b   Collier, David A ^a   Wöber Bingöl, Çiçek ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Department of Child and Adult Psychiatry ^*  (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 4 RECEPTOR;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHILD; DNA POLYMORPHISM; EXON; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIGRAINE WITHOUT AURA; NEUROPATHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; VARIABLE NUMBER OF TANDEM REPEAT;

ADOLESCENT; ADULT; ALLELES; CHILD; EXONS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIGRAINE WITHOUT AURA; MINISATELLITE REPEATS; RECEPTORS, DOPAMINE D4;

EID: 34447513278     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.21140     Document Type: Article

References (50)

1. Gervil M, Ulrich V, Kyvik KO, et al. Migraine without aura: a population-based twin study. Ann Neurol 1999;46:606-611.
2. Gervil M, Ulrich V, Kyvik KO, et al. The relative role of genetic and environmental factors in migraine without aura. Neurology 1999;53:995-999.
3. Ulrich V, Gervil M, Kyvik KO, et al. Evidence of a genetic factor in migraine with aura: a population-based Danish twin study. Ann Neurol 1999;45:242-246.
4. Smythies J. The dopamine system. Int Rev Neurobiol 2005;64:123-172.
5. Peroutka SJ. Dopamine and migraine. Neurology 1997;49:650-656.
6. Mascia A, Afra J, Schoenen J. Dopamine and migraine: a review of pharmacological, biochemical, neurophysiological, and therapeutic data. Cephalalgia 1998;18:174-182.
7. Fanciullaci M, Rosso AD. Dopamine involvement in the migraine attack. Funct Neurol 2000;15:171-181.
8. Chen SC. Epilepsy and migraine: the dopamine hypotheses. Med Hypotheses 2006;66:466-472.
9. Barbanti P, Fabbrini G, Ricci A, et al. Migraine patients show an increased density of dopamine D3 and D4 receptors on lymphocytes. Cephalalgia 2000;20:15-19.
10. Cerbo R, Barbanti P, Buzzi MG, et al. Dopamine hypersensitivity in migraine: role of the apomorphine test. Clin Neuropharmacol 1997;20:36-41.
11. Friedman BW, Corbo J, Lipton RB, et al. A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. Neurology 2005;64:463-468.
12. Brousseau DC, Duffy SJ, Anderson AC, Linakis JG. Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. Ann Emerg Med 2004;43:256-262.
13. Honkaniemi J, Liimatainen S, Rainesalo S, Sulavuori S. Haloperidol in the acute treatment of migraine: a randomized, double-blind, placebo-controlled study. Headache 2006;46:781-787.
14. Herzog AG. Continuous bromocriptine therapy in menstrual migraine. Neurology 1997;48:101-102.
15. Soyka D, Frieling B. [Lisuride for the prevention of migraine. Results of a multicenter study] Fortschr Med 1989;107:763-766.
16. Akerman S, Goadsby PJ. The role of dopamine in a model of trigeminovascular nociception. J Pharmacol Exp Ther 2005;314:162-169.
17. Del Zompo M, Cherchi A, Palmas MA, et al. Association between dopamine receptor genes and migraine without aura in a Sardinian sample. Neurology 1998;51:781-786.
18. Peroutka SJ, Wilhoit T, Jones K. Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles. Neurology 1997;49:201-206.
19. Peroutka SJ, Price SC, Wilhoit TL, et al. Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. Mol Med 1998;4:14-21.
20. Dichgans M, Forderreuther S, Deiterich M, et al. The D2 receptor NcoI allele: absence of allelic association with migraine with aura. Neurology 1998;51:928.
21. Lea RA, Dohy A, Jordan K, et al. Evidence for allelic association of the dopamine beta-hydroxylase gene (DBH) with susceptibility to typical migraine. Neurogenetics 2000;3:35-40.
22. Maude S, Curtin J, Breen G, et al. The -141C Ins/Del polymorphism of the dopamine D2 receptor gene is not associated with either migraine or Parkinson's disease. Psychiatr Genet 2001;11:49-52.
23. Shepherd AG, Lea RA, Hutchins C, et al. Dopamine receptor genes and migraine with and without aura: an association study. Headache 2002;42:346-351.
24. Stochino ME, Asuni C, Congiu D, et al. Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes. Pharmacol Res 2003;48:531-534.
25. Rebaudengo N, Rainero I, Parziale A, et al. Lack of interaction between a polymorphism in the dopamine D2 receptor gene and the clinical features of migraine. Cephalalgia 2004;24:503-507.
26. Mochi M, Cevoli S, Cortelli P, et al. A genetic association study of migraine with dopamine receptor 4, dopamine transporter and dopamine-beta- hydroxylase genes. Neurol Sci 2003;23:301-305.
27. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders. 2nd ed. Cephalalgia 2004;24(suppl 1):1-151.
28. Kienbacher C, Woeber C, Zesch HE, et al. Clinical features, classification and prognosis of migraine and tension-type headache in children and adolescents: a long-term follow-up study. Cephalalgia 2006;26:820-830.
29. Karwautz AFK, Campos de Sousa S, Wöber C, et al. Family-based analysis of serotonin transporter gene polymorphisms in migraine with & without aura. Cephalalgia (in press).
30. Freeman B, Powell J, Ball D, et al. DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behav Genet 1997;27:251-257.
31. Plomin R, Crabbe J. DNA. Psychol Bull 2000;126:806-828.
32. Shaikh S, Collier D, Kerwin RW, et al. Dopamine D4 receptor subtypes and response to clozapine. Lancet 1993;341:116.
33. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003;25:115-121.
34. Van Tol HH, Wu CM, Guan HC, et al. Multiple dopamine D4 receptor variants in the human population. Nature 1992;358:149-152.
35. Lichter JB, Barr CL, Kennedy JL, et al. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 1993;2:767-773.
36. Chang FM, Kidd JR, Livak KJ, et al. The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet 1996;98:91-101.
37. Brookes K, Xu X, Chen W, et al. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 2006;11:934-953.
38. Smalley SL, Bailey JN, Palmer CG, et al. Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder. Mol Psychiatry 1998;3427-3430.
39. Swanson J, Oosterlaan J, Murias M, et al. Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc Natl Acad Sci USA 2000;97:4754-4759.
40. Ding YC, Chi HC, Grady DL, et al. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci USA 2002;99:309-314.
41. Wang E, Ding YC, Flodman P, et al. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet 2004;74:931-944.
42. Jovanovic V, Guan HC, Van Tol HH. Comparative pharmacological and functional analysis of the human dopamine D4.2 and D4.10 receptor variants. Pharmacogenetics 1999;9:561-568.
43. Oak JN, Oldenhof J, Van Tol HH. The dopamine D(4) receptor: one decade of research. Eur J Pharmacol 2000;405:303-327.
44. Asghari V, Sanyal S, Buchwaldt S, et al. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995;65:1157-1165.
45. Schoots O, Van Tol HH. The human dopamine D4 receptor repeat sequences modulate expression. Pharmacogenomics J 2003;3:343-348.
46. Noain D, Avale ME, Wedemeyer C, et al. Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice. Eur J Neurosci 2006;24:2429-2438.
47. Pietrobon D, Striessnig J. Neurobiology of migraine. Nat Rev Neurosci 2003;4:386-398.
48. Chronicle EP, Pearson AJ, Mulleners WM. Objective assessment of cortical excitability in migraine with and without aura. Cephalalgia 2006;26:801-808.
49. Jasmin L, Burkey AR, Granato A, et al. Rostral agranular insular cortex and pain areas of the central nervous system: a tract-tracing study in the rat. J Comp Neurol 2004;468:425-440.
50. Burkey AR, Carstens E, Jasmin L. Dopamine reuptake inhibition in the rostral agranular insular cortex produces antinociception. J Neurosci 1999;4169-4179.