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Bohmig GA, Wahrmann M, Regele H, et al. Immunoadsorption in severe C4d-positive acute kidney allograft rejection: a randomized controlled trial. Am J Transplant 2007; 7:117-121. This describes the only randomized trial to date comparing antibody reduction strategies with medication therapy alone for C4d postive antibody-mediated rejection.
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Stegall MD, Gloor J, Winters JL, et al. A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody. Am J Transplant 2006; 6:346-351. This study highlighted the limitations of using IVIg as a desensitization tool and suggests that more than one strategy may ultimately be necessary to get sensitized patients transplanted.
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Haas M, Montgomery RA, Segev DL, et al. Subclinical acute antibody-mediated rejection in positive crossmatch renal allografts. Am J Transplant 2007; 7:576-585. This pathologic study suggested that a subset of patients who undergo living donor transplantation across a positive crossmatch will develop a form of subacute antibody mediated rejection that could jeopardize future allograft function.
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de Klerk M, Witvliet MD, Haase-Kromwijk BJ, et al. A highly efficient living donor kidney exchange program for both blood type and crossmatch incompatible donor-recipient combinations. Transplantation 2006; 82: 1616-1620. Despite requiring large numbers of donor:recipient pairs, this study shows that sensitized patients can undergo transplantation through paired:kidney exchange programs.
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