F02-2172, factor Xa inhibitors from metabolites of microorganisms

Chinese Journal of Antibiotics

Volumn 32, Issue 5, 2007, Pages 277-279

  Lu, Xin Hua ^a   Zhang, Zhi Hui ^a   Ma, Ying ^a   Shi, Ying ^a   Dong, Yue Sheng ^a   Ren, Xiao ^a   Mu, Dong ^a   Zhang, Hua ^a   He, Jian Gong ^a  

^a North China Pharmaceutical Corporation   (China)

Author keywords

Factor Xa inhibitor; Microorganisms; Sesterterpenes

Indexed keywords

6 EPI OPHIOBOLIN K; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; F02 2172A; F02 2172B; F02 2172C; OPHIOBOLIN G; OPHIOBOLIN K; SEPHADEX; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; FUNGAL STRAIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; SOLVENT EXTRACTION; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROSCOPY;

EID: 34447507678     PISSN: 10018689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Daure E W, Fujikawa K, Kisiel W. The coagulation cascude: Initiation, maintenance and regulation [J]. Biochemistry,1991,30(42):10363
2. Nagahara T, Yokoyama Y, Inamwara K, et al. Dibasic (amidinoargl) propanoic acid derivatives as novel blood coagulation factor Xa inhibitors [J]. J Pharm Sci,1994,83 (9):1200
3. Quan M L, Smallheer J M. The race to an orally active factor Xa inhibitor: recent advances [J]. Curr Opin Drug Discov Devel,2004,7(4):460
4. Pancras C, Wong Earl J, Crain Carol A, et al. Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits [J]. J Pharmacol Exp Ther,2002,303(3): 993
5. Singh S B, Smith J L, Sabnis G S. Structure and conformation of ophiobolin K and 6-epiophiobolin K from Aspergillus ustus as a nematocidal agent [J]. Tetrahedron, 1991,47(34):6931
6. Wei H, Itoh T, Kinoshita M, et al. Cytotoxic sesterpenes, 6-epi-ophiobolin G and 6-epi-ophiobolin N, from marine derived fungus Emericella variecolor GF10 [J]. Tetrahedron,2004,60(28):6015
7. Au T K, Chick W S, Leung P C. The biology of ophiobolins [J]. Life Sci,2000,67(7):733
8. Morisaki M, Nozoe S, Iitaka Y. X-ray studies of C25 terpenoids I. The crystal structure of ophiobolin methoxybromide [J]. Acta Crystallogr B,1968,24(10):1293
9. Leung PC, Taylor W A, Wang J H. et al. Ophiobolin A. A natural product inhibitor of calmodulin [J]. J Biol Chem,1984,259(5):2742