An improved high-performance liquid chromatographic method with a solid-phase extraction for the determination of piperacillin and tazobactam: Application to pharmacokinetic study of different dosage in Chinese healthy volunteers

Biomedical Chromatography

Volumn 21, Issue 7, 2007, Pages 680-686

  Xia, Chun Hua ^a,b   Xiong, Yu Qing ^a   Wang, Guang Ji ^b  

^a NANCHANG UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

High performance liquid chromatography (HPLC); Pharmacokinetics; Piperacillin tazobactam; Solid phase extraction

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; EXTRACTION; PHARMACOKINETICS; PHASE SEPARATION; PLASMA (HUMAN); SODIUM COMPOUNDS;

HEALTHY VOLUNTEERS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN PLASMAS; PHARMACOKINETIC STUDIES; PIPERACILLIN; PIPERACILLIN-TAZOBACTAM; SOLID-PHASE EXTRACTION; TAZOBACTAM;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETONITRILE; METHANOL; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; SODIUM DIHYDROGEN PHOSPHATE; TAZOBACTAM;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CHINESE; CONTROLLED STUDY; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG ISOLATION; DRUG RETENTION; DRUG STABILITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHARMACODYNAMICS; RELIABILITY; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; VOLUNTEER;

EID: 34447501738     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.800     Document Type: Article

References (9)

1. Augey V, Grosset PY, Albert G and Audran M. High-performance liquid chromatographic determination of tazobactam and piperacillin in human plasma and urine. Journal of Chromatography B 1996; 682: 125-136.
2. Bourget P, LesneHulin A, LeReveille R and LeBever H. Clinical pharmacokinetics of piperacillin-tazobactam combination in patients with major burns and signs of infection. Antimicrob Agents Chemotherapeutics 1996; 40: 139-145.
3. Delapena AS, Asperger W, Kockerling F and Raz R. Efficacy and safely of ertapenem versus piperacillin-tazobactam for the treatment of intra-abdominal infections requiring surgical intervention. Journal of Gastrointestinal Surgery 2006; 10: 567-574.
4. Giordano P, Song J and Pertel P. Sequential intravenous/oral moxifloxacin versus intravenous piperacillin-tazobactam followed by oral amoxicillin-clavulanate for the treatment of complicated skin and skin structure infection. International Journal of Antimicrobial Agents 2005; 26: 357-365.
5. Kinzig M, Sorgel F, Brismar B and Nord CE. Pharmacokinetics and tissue penetration of tazobactam and piperacillin in patients undergoing colorectal surgery. Antimicrobial Agents and Chemothreapy 1992; 36: 1997-2004.
6. Marselos SC and Archontaki HA. Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of piperacillin and tazobactam in tazocin injectable powder. Journal of Pharmaceutical and Biomedical Analysis 2002; 29: 787-793.
7. Ocampo AR, Hoyt KD, Wadgaonkar N and Carver AH. Determination of tazobactam and piperacillin in human plasma, serum, bile, and urine by gradient elution reversed-phase high-performance liquid chromatography. Journal of Chromatography 1989; 496: 176-172.
8. Siami FS, LuFleur BJ and Siami GA. Clinafloxacin versus piperacillin/ tazobactam in the treatment of severe skin and soft-tissue infections in adults at a veterans affairs medical center. Clinical Therapeutics 2002; 24: 59-72.
9. Trittler R, Ehrlich M, Galla TJ, Horch RE and Kummerer K. New and rapid fully automated method for determination of tazobactam and piperacillin in fatty tissue and serum by column-switching liquid chromatography. Journal of Chromatography B 2002; 775: 127-132.