Evaluation of the content homogeneity and dispersion properties of fluticasone DPI compositions

Journal of Drug Delivery Science and Technology

Volumn 17, Issue 3, 2007, Pages 223-229

  Sebti, T ^a,b   Vanderbist, F ^b   Amighi, K ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b SMB Galephar Pharmaceuticals   (Belgium)

Author keywords

Carrier; Dry powder inhaler; Fluticasone; Homogeneity; Mixers

Indexed keywords

FLUTICASONE PROPIONATE; LACTOSE; MICROFINE 20; MICROFINE 80; PHARMATOSE DCL 21; UNCLASSIFIED DRUG;

AEROSOL; ARTICLE; DRUG FORMULATION; DRUG STABILITY; EQUIPMENT; EVALUATION; FLOW; INHALATION; POWDER INHALER;

EID: 34447341180     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(07)50040-7     Document Type: Article

References (11)

1. Hindle H., Jashnani R.N., Byron P.R. - Dose emissions from marketed inhalers: influence of flow, volume and environment. - Respir. Drug Deliv., IV, 137-142, 1994.
2. Ganderton D. - Generation of respirable clouds from coarse powder aggregates. - J. Biopharm. Sci., 3, 101-105, 1992.
3. Dalby R.N., Hickey A.J., Tiano S.L. - Medical devices for the delivery of therapeutic aerosol to the lungs. - In: Inhalation Aerosols Physical and Biological Basis for Therapy, A.J. Hickey Ed., Marcel Dekker, New York, 1996, pp. 449-472.
4. Gupta P.K., Hickey A.J. - Contemporary approaches in aerolized drug delivery to the lung. - J. Control. Release, 17, 127-147, 1991.
5. Kawashima Y., Serigano T., Hino T., Yamamoto H., Takeuchi H. - Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate. - Int. J. Pharm., 172, 179-188, 1998.
6. Larhrib H., Zeng X.M., Martin G.P., Marriott C., Pritchard J. - The use of different grades of lactose as a carrier for aerosolised salbutamol sulphate. - Int. J. Pharm., 191, 1-14, 1999.
7. Schiavone H., Palakodaty S., Clark A., York P., Tzannis S.T. - Evaluation of SCF engineered particle-based lactose blends in passive dry powder inhalers. - Int. J. Pharm., 281, 55-66, 2004.
8. Staniforth J.N. - Improvement in dry powder inhaler performance: surface passivation effects. - Proceedings of Drug Delivery to the Lungs VII, The Aerosol Society, London, 1996, pp. 86-89.
9. Lucas P., Anderson K., Staniforth J.N. - Protein deposition from dry powder inhalers: fine particle multiplets as performance modifiers. - Pharm. Res., 15, 562-569, 1998.
10. Karhu M., Kuikka J., Kauppinen T., Bergstrom K., Vidgren M. - Pulmonary deposition of lactose carriers used in inhalation powders. - Int. J. Pharm., 196, 95-103, 2000.
11. Zeng X.M., Pandhal K.H., Martin G.P. - The influence of lactose carrier on the content homogeneity and dispersibility of beclomethasone dipropionate from dry powder aerosols. - Int. J. Pharm., 197, 41-52, 2000.