A new and efficient synthesis of the HMG-CoA reductase inhibitor pitavastatin

Helvetica Chimica Acta

Volumn 90, Issue 6, 2007, Pages 1069-1081

  Acemoglu, Murat ^a   Brodbeck, Andre ^a   Garcia, Angel ^a   Grimier, Dominique ^a   Hassel, Marc ^a   Riss, Bernhard ^a   Schreiber, Robert ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COUPLING REACTIONS; ESTER DERIVATIVES; PITAVASTATIN;

AMIDES; AMINES; BIOSYNTHESIS; ENANTIOMERS; ENZYME KINETICS; ESTERS; REACTION KINETICS;

ENZYME INHIBITION;

1 PHENYL ETHYLAMINE; 3 [[(TERT BUTYL)DIMETHYLSILYL]OXY] 5 [[(NAPHTHALEN 1 YL)ETHYL]AMINO] 5 OXOPENTANOIC ACID; 3 [[(TERT BUTYL)DIMETHYLSILYL]OXY] 5 [[(NAPHTHALEN 2 YL)ETHYL]AMINO] 5 OXOPENTANOIC ACID; 3 [[(TERT BUTYL)DIMETHYLSILYL]OXY] 5 OXO 5 [[1 PHENYLETHYL]AMINO]PENTANOIC ACID; 3 [[(TERT BUTYL)DIMETHYLSILYL]OXY] 7 [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL] 5 OXO [1 PHENYLETHYL]HEPT 6 ENAMIDE; 3 [[(TERT BUTYL)DIMETHYLSILYL]OXY]GLUTARIC ANHYDRIDE; 3 [[(TERT BUTYL)DIMETHYLSILYL]OXY]N 1 METHOXY N 1 METHYL N 5 [1 PHENYLETHYL]PENTANEDIAMIDE; 4 [[(TERT BUTYL)DIMETHYLSILYL]OXY] 2,6 DIOXO 6 [[[1 PHENYLETHYL]AMINO]HEXYL]PHOSPHONIC ACID DIETHYL ESTER; 4 [[(TERT BUTYL)DIMETHYLSILYL]OXY] 2,6 DIOXO 6 [[[1 PHENYLETHYL]AMINO]HEXYL]PHOSPHONIC ACID DIMETHYL ESTER; 6 [2 [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]ETHENYL]TETRAHYDROXY PYRAN 2 ONE; 7 [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL] 3 HYDROXY 5 OXO [1 PHENYLETHYL]HEPT 6 ENAMIDE; 7 [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL] 3,5 DIHYDROXY HEPT 6 ENOIC ACID; 7 [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL] 3,5 DIHYDROXY[1 PHENYLETHYL]HEPT 6 ENAMIDE; ALDEHYDE; AMIDE; ATORVASTATIN; ESTER DERIVATIVE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEVALO; PITAVASTATIN; ROSUVASTATIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; PRIORITY JOURNAL;

EID: 34447335377     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200790106     Document Type: Article

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