Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures

Journal of Andrology

Volumn 28, Issue 4, 2007, Pages 521-527

  Boxmeer, Jolanda C ^a   Smit, Marij ^a   Weber, Robertus F ^a   Lindemans, Jan ^a   Romijn, Johannes C ^a   Eijkemans, Marinus J ^a   Macklon, Nicholas S ^b   Steegers Theunissen, Regine P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Assisted reproduction; Folate; Homocysteine; Semen analysis

Indexed keywords

COBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE; TESTOSTERONE;

ADULT; ARTICLE; BLOOD LEVEL; DISEASE SEVERITY; ERYTHROCYTE LEVEL; FERTILIZATION IN VITRO; HUMAN; HYPERHOMOCYSTEINEMIA; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MALE; MALE GENITAL SYSTEM; MORPHOLOGY; PRIORITY JOURNAL; SEMEN ANALYSIS; SPERMATOGENESIS; SPERMATOZOON MOTILITY; TESTOSTERONE BLOOD LEVEL; VITAMIN DEFICIENCY; WORLD HEALTH ORGANIZATION;

ADULT; BIOLOGICAL MARKERS; FERTILIZATION IN VITRO; FOLIC ACID; HOMOCYSTEINE; HUMANS; INFERTILITY, MALE; MALE; MIDDLE AGED; PYRIDOXAL PHOSPHATE; SEMEN; SPERM COUNT; SPERM INJECTIONS, INTRACYTOPLASMIC; SPERMATOGENESIS; VITAMIN B 12;

EID: 34447335061     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.106.001982     Document Type: Article

References (22)

1. Blair JH, Stearns HE, Simpson GM. Vitamin B 12 and fertility. Lancet. 1968;1:49-50.
2. Ebisch IMW, Peters WHM, Thomas CMG, Wetzels AMM, Peer PGM, Steegers-Theunissen RPM. Homocysteine, glutathione and related thiols affect fertility parameters in the (sub)fertile couple. Hum Reprod. 2006;21:1725-1733.
3. Jackson I, Doig WB, McDonald G. Pernicious anaemia as a cause of infertility. Lancet. 1967;2:1159-1160.
4. Kuroki Y, Iwamoto T, Lee JW, Yoshiike M, Nozawa S, Nishida T, Ewis AA, Nakamura H, Toda T, Tokunaga K, Kotliarova SE, Kondoh N, Koh E, Namiki M, Shinka T, Nakahori Y. Spermatogenic ability is different among males in different Y chromosome lineage. J Hum Genet. 1999;44:289-292.
5. Mahmood A. Pernicious anaemia as a cause of infertility. Lancet. 1971;1:753.
6. Ombelet W, Bosmans E, Janssen M, Cox A, Vlasselaer J, Gyselacrs W, Vandeput H, Gielen J, Pollet H, Maes M, Steeno O, Kruger T. Semen parameters in a fertile versus subfertile population: a need for change in the interpretation of semen testing. Hum Reprod. 1997;12:987-993.
7. Pfeiffer CM, Huff DL, Gunter EW. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin Chem. 1999;45:290-292.
8. Plassmann S, Urwyler H. Improved risk assessment by screening sperm parameters. Toxicol Lett. 2001;119:157-171.
9. Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, Johnston C, Engbaek F, Schneede J, McPartlin C, Scott JM. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem. 2004;50:3-32.
10. Schrijver J, Speek AJ, Schreurs WH. Semi-automated fluorometric determination of pyridoxal-5′-phosphate (vitamin B6) in whole blood by high-performance liquid chromatography (HPLC). Int J Vit Nutr Res. 1981;51:216-222.
11. Sharp AA, Witts LJ. Seminal vitamin B12 and sterility. Lancet. 1962;1:779.
12. Steegers-Theunissen RP, Boers GH, Blom HJ, Trijbels FJ, Eskes TK. Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet. 1992;339:1122-1123.
13. Steegers-Theunissen RP, Boers GH, Trijbels FJ, Eskes TK. Neural-tube defects and derangement of homocysteine metabolism. N Engl J Med. 1991;324:199-200.
14. Tomaszewski L, Zmudzka B, Nadworny J. Seminal vitamin B12 and sterility. Lancet. 1963;1:170.
15. van der Merwe FH, Kruger TF, Oehninger SC, Lombard CJ. The use of semen parameters to identify the subfertile male in the general population. Gynecol Obstet Invest. 2005;59:86-91.
16. Varadi S. Pernicious anaemia and infertility. Lancet. 1967;1:1350.
17. Verjans HL, Cooke BA, de Jong FH, de Jong CM, van der Molen HJ. Evaluation of a radioimmunoassay for testosterone estimation. J Steroid Biochem. 1973;4:665-676.
18. Wallock LM, Tamura T, Mayr CA, Johnston KE, Ames BN, Jacob RA. Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and non-smokers. Fertil Steril. 2001;75:252-259.
19. Watson AA. Seminal vitamin B12 and sterility. Lancet. 1962;1:644.
20. Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RPM. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002;77:491-498.
21. Wong WY, Thomas CMG, Merkus JMWM, Zielhuis GA, Steegers-Theunissen RPM. Male factor subfertility: possible causes and the impact of nutritional factors. Fertil Steril. 2000;73:435-442.
22. World Health Organization. Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. 4th ed. Cambridge, United Kingdom: Cambridge University Press, 1999.