Cyclosporine monitoring in the early post-transplant period in pediatric liver transplant recipients

Pediatric Transplantation

Volumn 11, Issue 5, 2007, Pages 530-535

  Frauca, E ^a   Diaz, M C ^a   De La Vega, A ^a   Hierro, L ^a   Camarena, C ^a   Bartolo, G Muñoz ^a   Diez R ^a   Murcia, J ^a   Gamez M ^a   Peinado, C Sanchez ^a   Santamaría, M López ^a   Andres I ^b   Jara, P ^a,c  

^a HOSPITAL INFANTIL LA PAZ   (Spain)

^b Immunology Unit   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

C2; Cyclosporine; Liver transplantation; Pediatric; Pharmacokinetic

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN A; METHYLPREDNISOLONE; TACROLIMUS;

ABDOMINAL INFECTION; AREA UNDER THE CURVE; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG MONITORING; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT REJECTION; HUMAN; INFANT; LIVER BIOPSY; LIVER GRAFT; LIVER TRANSPLANTATION; MALE; SURVIVAL RATE; SYSTEMIC INFECTION; VIRUS INFECTION;

ACUTE DISEASE; CHILD, PRESCHOOL; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; LIVER TRANSPLANTATION; MALE; POSTOPERATIVE PERIOD; SPAIN; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 34447331073     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2007.00697.x     Document Type: Article

References (14)

1. Trull AK, Tan KKC, Uttridge J, Bauer T, Alexander GJM, Jamieson NV. Cyclosporin absorption from microemulsion formulation in liver transplant recipients. Lancet 1993 : 341 : 433.
2. Burckart G, Starzl TE, Williams L, et al. Cyclosporine monitoring and pharmacokinetics in pediatric liver transplant patients. Transplant Proc 1985 : 17 : 1172 1175.
3. Whitington PF, Kehrer BH, Whitington SH, Shneider B, Black DD. The effect of biliary enteroenterostomy on the pharmacokinetics of enterally administered cyclosporine in rats. Hepatology 1989 : 9 : 393 397.
4. Kovarik JM, Mueller EA, Van Bree JB, Tetzloff W, Kutz K. Reduced inter and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation. J Pharm Sci 1994 : 83 : 444 446.
5. Mueller EA, Kallay Z, Kovarik JM, et al. Bile-independent absorption of cyclosporine from a microemulsion formulation in liver transplant patients. Transplantation 1995 : 60 : 515 517.
6. Levy G, Burra P, Cavallari A, et al. Improved clinical outcomes for liver transplant recipients using cyclosporine monitoring based on 2-hr post-dose levels (C2). Transplantation 2002 : 73 : 953 959.
7. Kovarik JM, Hoyer PF, Ettenger R, Punch J, Soergel M. Cyclosporine absorption profiles in pediatric kidney and liver transplant patients. Pediatr Nephrol 2003 : 18 : 1275 1279.
8. Dunn S, Falkenstein K, Cooney G. Neoral C(2) monitoring in pediatric liver transplant recipients. Transplant Proc 2001 : 33 : 3094 3095.
9. Kelly D, Jara P, Rodeck B, et al. Tacrolimus and steroids versus ciclosporin microemulsion, steroids, and azathioprine in children undergoing liver transplantation: Randomised European multicentre trial. Lancet 2004 : 364 : 1054 1061.
10. Alvarez F, Atkison PR, Grant DR, et al. NOF-11: A one-year pediatric randomized double-blind comparison of neoral versus sandimmune in orthotopic liver transplantation. Transplantation 2000 : 69 : 87 92.
11. Burdelski MM. The impact of cyclosporine on the development of immunosuppressive therapy for pediatric liver transplantation. Transplant Proc 2004 : 36 : 295S 298S.
12. Uribe M, Buckel E, Ferrario M, et al. Pediatric liver transplantation: Ten years of experience in a multicentric program in Chile. Transplant Proc 2005 : 37 : 3375 3377.
13. Wallemacq PE, Reding R, Sokal EM, et al. Clinical pharmacokinetics of neoral in pediatric recipients of primary liver transplants. Transpl Int 1997 : 10 : 466 470.
14. Dunn SP. Neoral monitoring 2 hours post-dose and the pediatric transplant patient. Pediatr Transplant 2003 : 7 : 25 30.