Correlation of maternal plasma total cell-free DNA and fetal DNA levels with short term outcome of first-trimester vaginal bleeding

Human Reproduction

Volumn 22, Issue 6, 2007, Pages 1736-1743

  Yin, Aihua ^a,b   Ng, E H Y ^c   Zhang, Xiangzhong ^d   He, Yunshao ^a   Wu, Jing ^b   Leung, K Y ^c  

^a SUN YAT SEN UNIVERSITY   (China)

^b Maternal and Child Health Hospital of Guangdong Province   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Fetal DNA; Maternal plasma; Spontaneous abortion; Total DNA

Indexed keywords

BETA GLOBIN; DNA; GENE PRODUCT; PROTEIN DYS14; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL FREE SYSTEM; CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA CONTENT; DNA DETERMINATION; FALSE POSITIVE RESULT; FEMALE; FETUS; FIRST TRIMESTER PREGNANCY; GESTATION PERIOD; HUMAN; MAJOR CLINICAL STUDY; MALE; MATERNAL PLASMA; PREDICTION; PREGNANCY OUTCOME; REFERENCE VALUE; SPONTANEOUS ABORTION; STATISTICAL SIGNIFICANCE; VAGINA BLEEDING;

EID: 34447330701     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dem058     Document Type: Article

References (46)

1. Al Sebai MA, Diver M et al. The role of single free beta human chorionic gonadotropin measurement in the diagnosis of early pregnancy failure and the prognosis of fetal viability. Hum Reprod 1996; 11:881-8.
2. Bauer M, Hutterer G, Eder M et al. A prospective analysis of cell-free fetal DNA concentration in maternal plasma as an indicator for adverse pregnancy outcome. Prenat Diagn 2006;26:831-6.
3. Benson CB, Doubilet PM. Slow embryonic heart rate in early first trimester: Indicator of poor pregnancy outcome. Radiology 1994; 192:343-4.
4. Bianchi DW. Circulating fetal DNA: Its origin and diagnostic potential - a review. Placenta 2004;25 (Suppl A):S93-S101.
5. Birch L, English CA, O'Donoghue K et al. Accurate and robust quantification of circulating fetal and total DNA in maternal plasma from 5 to 41 weeks of gestation. Clin Chem 2005;51:312-20.
6. Bischoff FZ, Lewis DE, Simpson JL. Cell-free fetal DNA in maternal blood: Kinetics, source and structure. Hum Reprod Update 2005; 11:59-67.
7. Bremme K, Eneroth P, Nord E. An evaluation of early pregnancy HCG determination as a prognostic tool for fetal outcome. Gynecol Obstet Invest 1983;16:160-171.
8. Caramelli E, Rizzo N, Councu M et al. Cell-free fetal DNA concentration in plasma of patients with abnormal uterine artery Doppler waveform and intrauterine growth restriction-a pilot study. Prenat Diagn 2000;23:367-71.
9. Chan LY, Leung TN, Chan KC et al. Serial analysis of fetal DNA concentrations in maternal plasma in late pregnancy. Clin Chem. 2003;49:678-80.
10. Chittacharoen A, Herabutya Y. Slow fetal heart rate may predict pregnancy outcome in first-trimester threatened abortion. Fertil Steril 2004;82:227-9.
11. Chiu RW, Poon LL, Lau TK et al. Effects of blood-processing protocols on fetal and total DNA quantification in maternal plasma. Clin Chem 2001;47:1607-13.
12. Dickey RP, Gasser RF, Olar TT et al. The relationship of initial embryo crown-rump length to pregnancy outcome and abortus karyotypes based on new growth curves for the 2-31 mm embryo. Hum Reprod 1994;9:366-73.
13. Doubilet PM, Benson CB, Choro JS. Long-term prognosis of pregnancies complicated by slow embryonic heart rates in the early first trimester. J Ultrasound Med 1999;18:537-41.
14. Falco P, Milano V, Pilu G et al. Sonography of pregnancies with first-trimester bleeding and a viable embryo: A study of prognostic indicators by logistic regression analysis. Ultrasound Obstet Gynecol 1996;7:165-9.
15. Farina A, Sekizawa A, Iwasaki M et al. Total cell-free DNA (beta-globin gene) distribution in maternal plasma at the second trimester: A new prospective for preeclampsia screening. Prenat Diagn 2004;24:722-6.
16. Farina A, LeShane ES, Romero R et al. High levels of fetal cell-free DNA in maternal serum: A risk factor for spontaneous preterm delivery. Am J Obstet Gynecol 2005;193:421-5.
17. Florio P, Luisi S, D'Antona D et al. Maternal serum inhibin A levels may predict pregnancy outcome in women with threatened abortion. Fertil Steril 2004;81:468-70.
18. Goldstein SR. Embryonic ultrasonographic measurements: Crown-rump length revised. Am J Obstet Gynecol 1991;165:497-501.
19. Jimbo M, Sekizawa A, Sugito Y et al. Placenta increta: Postpartum monitoring of plasma cell-free fetal DNA. Clin Chem 2003;49 1540-1.
20. Lazar L, Nagy B, Ban Z et al. Presence of cell-free fetal DNA in plasma of women with ectopic pregnancies. Clin Chem. 2006;52 1599-601.
21. Lee T, LeShane ES, Messerlian GM et al. Down syndrome and cell-free fetal DNA in archived maternal serum. Am J Obstet Gynecol 2002;187: 1217-21.
22. Leung TN, Zhang J, Lau TK et al. Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia. Clin Chem 2001;47:137-9.
23. Leylek OA, Senocak F, Erselcan T. The prognostic predictive value of maternal serum CA 125 levels in threatened abortion. Int J Gynaecol Obstet 1997;59:147-9.
24. Lipscomb GH, Stovall TG, Ling FW. Nonsurgical treatment of ectopic pregnancy. N Engl J Med 2000;343:1325-9.
25. Lo YM, Corbetta N, Chamberlain PF et al. Presence of fetal DNA in maternal plasma and serum. Lancet 1997;350:485-7.
26. Lo YM, Tein MS, Lau TK et al. Quantitative analysis of fetal DNA in maternal plasma and serum: Implication for noninvasive prenatal diagnosis. Am J Hum Genet 1998;62:768-75.
27. May DA, Sturtevant NV. Embryonal heart rate as a predictor of pregnancy outcome: A prospective analysis. J Ultrasound Med 1991;10 591-3.
28. Miura K, Yoshiura K, Miura S et al. Cell-free DNA is more sensitive than cell-free mRNA as a marker for evaluation of fetal-maternal hemorrhage. Clin Chem 2006;52:2121-3.
29. Nardo LG, Sallam HN. Progesterone supplementation to prevent recurrent miscarriage and to reduce implantation failure in assisted reproduction cycles. Reprod Biomed Online 2006;13:47-57.
30. Ocer E, Bese T, Saridogan E et al. The prognostic significance of maternal CA125 measurement in threatened abortion. Eur J Obstet Gynecol Reprod Biol 1992;46:137-42.
31. Qasim SM, Sachdev R, Trias A et al. The predictive value of first-trimester embryonic heart rates in infertility patients. Obstet Gynecol 1997;89:934-6.
32. Reis FM, D'Antona D, Petraglia F. Predictive value of hormone measurements in maternal and fetal complications of pregnancy. Endocrine Rev 2002;23:230-57.
33. Reljic M. The significance of crown-rump length measurement for predicting adverse pregnancy outcome of threatened abortion. Ultrasound Obstet Gynecol 2001;17:510-2.
34. Sekizawa A, Jimbo M, Saito H et al. Increased cell-free fetal DNA in plasma of two women with invasive placenta. Clin Chem 2002; 48:353-4.
35. Sekizawa A, Farina A, Koide K et al. Beta-globin DNA in maternal plasma as a molecular marker of pre-eclampsia. Prenat Diagn 2004;24:697-700.
36. Skinner J, Luettich Y, Ring M et al. Fetal DNA in maternal circulation of first-trimester spontaneous abortions. Obstet Gynecol 2001;97:460-3.
37. Spencer K, de Kok JB, Swinkels DW. Increased total cell-free DNA in the serum of pregnant women carrying a fetus affected by trisomy 21. Prenat Diagn 2003;23:580-3.
38. Stanghellini I, Bertorelli R, Capone L. Quantitation of fetal DNA in maternal serum during the first trimester of pregnancy by the use of a DAZ repetitive probe. Mol Hum Reprod 2006;12:587-91.
39. Tannirandom Y, Sangsawang S, Manotaya S. Fetal loss in threatened abortion after embryonic/fetal heart activity. Int J Gynaecol Obstet 2003; 81:263-6.
40. Tempfer CB, Kurz C, Bentz EK et al. A combination treatment of prednisone, aspirin, folate, and progesterone in women with idiopathic recurrent miscarriage: A matched-pair study. Fertil Steril 2006; 86:145-8.
41. Tjoa ML, Cindrova-Davies T, Spasic-Boskovic O et al. Trophoblastic Oxidative Stress and the Release of Cell-Free Feto-Placental DNA. Am J Pathol 2006;169:400-4.
42. Wataganara T, Chen AY, LeShane ES et al. Cell-free fetal DNA levels in maternal plasma after elective first-trimester termination of pregnancy. Fertil Steril 2004;81:638-44.
43. Wilson RD, Kendrick V, Wittmann BK et al. Risk of spontaneous abortion in ultrasonically normal pregnancy. Lancet 1984;20 920-1.
44. Zhong XY, Burk MR, Troeger C et al. Fetal DNA in maternal plasma is elevated in pregnancies with aneuploid fetuses. Prenat Diagn 2000;20:795-8.
45. Zhong XY, Steinborn A, Sohn C et al. High levels of circulatory erythroblasts and cell-free DNA prior to intrauterine fetal death. Prenat Diagn 2006;26:1272-3.
46. Zimmermann B, El-Sheikhah A, Nicolaides K et al. Optimized real-time quantitative PCR measurement of male fetal DNA in maternal plasma. Clin Chem 2005;51:1598-1604.