Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

European Journal of Clinical Pharmacology

Volumn 63, Issue 8, 2007, Pages 761-767

  Villesen, Hanne H ^a   Kristensen, Kim ^b   Hansen, Steen H ^a   Jensen, Niels Henrik ^c   Skram, Ulrik ^d   Christrup, Lona L ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ASTRAZENECA R AND D   (Sweden)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^d Mental Health Center Glostrup   (Denmark)

Author keywords

Absorption; M6G formation; Morphine; Morphine 6 glucuronide (M6G); Pharmacokinetic

Indexed keywords

MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; PARACETAMOL; SALAZOSULFAPYRIDINE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; COLON; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG GLUCURONIDATION; DRUG METABOLISM; DUODENUM; GASTROINTESTINAL ABSORPTION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE;

ABSORPTION; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANALGESICS, OPIOID; CROSS-OVER STUDIES; HUMANS; HYDROLYSIS; MALE; MORPHINE; MORPHINE DERIVATIVES;

EID: 34447328419     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-007-0306-4     Document Type: Article

References (16)

1. Romberg R, Olofsen E, Sarton E, den Harting J, Taschner PEM, Dahan A (2004) Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide- induced analgesia in healthy volunteers. Anesthesiology 100:120-133
2. Thomson PI, Joel S, John L, Wedzicha JA, Maclean M, Slevin M (1995) Respiratory depression following morphine and morphine-6-glucuronide in normal subjects. Br J Clin Pharmacol 40:145-152
3. Skarke C, Darimont J, Schmidt H, Geisslinger G, Lötsch J (2003) Analgesic effects of morphine and morphine-6-glucuronide in an transcutaneous electric pain model in healthy volunteers. Clin Pharmacol Ther 73:107-121
4. Cann C, Curran J, Milner T, Ho B (2002) Unwanted effects of morphine-6-glucoronide and morphine. Anaestesia 57:1200-1203
5. Romberg R, Olofsen E, Sarton E, Teppema L, Dahan A (2003) Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy volunteers. Anesthesiology 99:788-798
6. Peat SJ, Hanna MH, Woodham M, Knibb A, Ponte J (1991) Morphine-6-glucuronide: effects on ventilation in normal volunteers. Pain 45:101-104
7. Penson RT, Joel SP, Roberts M, Gloyne A, Beckwith S, Slevin ML (2002) The bioavailability and pharmacokinetics of subcutaneous, nebulized and oral morphine-6-glucuronide. Br J Clin Pharmacol 53:347-354
8. Villesen HH, Hedal B, Engbaek J et al (2006) Pharmacokinetics of M6G following intravenous and oral administration in healthy volunteers. Acute Pain 8:63-71
9. Stain-Texier F, Sandouk P, Scherrmann J-M (1998) Intestinal absorption and stability of morphine-6-glucuronide in different physiological compartments of the rat. Drug Metab Dispos 26:383-387
10. Chapman DJ (1990) Analysis and pharmacokinetics of morphine and morphine-6-glucuronide. University of Surrey, UK
11. Lötsch J, Stockmann A, Kobal G et al (1996) Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers. Clin Pharmacol Ther 60:316-325
12. Osborne R, Thompson P, Joel S, Trew D, Patel SS, levin M (1992) The analgesic activity of morphine-6-glucuronide. Br J Pharmacol 34:130-138
13. Lötsch J, Weiss M, Kobal G, Geisslinger G (1998) Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration. Clin Pharmacol Ther 63:629-639
14. Christrup LL, Froekjaer S, Villesen HH (2006) Morphine-6-Glucuronide: the clinical potential after oral administration. Permation of isolated rat gut segments. Eur J Pharm Biopharm. unpublished data
15. Sunesen VH, Vedelsdal R, Kristensen HG, Christrup L, Mullertz A (2005) Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug. Eur J Pharm Sci 24:297-303
16. Rowland M, Tozer TN (1995) Clinical pharmacokinetics. Concepts and applications, 3rd edn. Lippincott Williams & Wilkins, Philadelphia