Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 16, 2007, Pages 4654-4656

  Cressina, Elena ^a   Lloyd, Adrian J ^b   De Pascale, Gianfranco ^a,b   Roper, David I ^b   Dowson, Christopher G ^b   Bugg, Timothy D H ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Antibacterial; Inhibitor; MurM; Peptidoglycan biosynthesis; Streptococcus pneumoniae

Indexed keywords

2' DEOXYADENOSINE PHOSPHONATE; ADENOSINE; ADENOSINE PHOSPHONATE INHIBITOR; ALANINE TRANSFER RNA LIGASE; BACTERIAL PROTEIN; LIPID A; PENICILLIN DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PROTEIN INHIBITOR; PROTEIN MURM; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; STREPTOCOCCUS PNEUMONIAE;

ADENINE NUCLEOTIDES; BACTERIAL PROTEINS; MOLECULAR STRUCTURE; PEPTIDE SYNTHASES; STREPTOCOCCUS PNEUMONIAE; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID;

POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 34447325905     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.071     Document Type: Article

References (13)

1. Garcia-Bustos J., and Tomasz A. Proc. Natl. Acad. Sci. USA 87 (1990) 5414
2. Filipe S.R., and Tomasz A. Proc. Natl. Acad. Sci. USA 97 (2000) 4891
3. Rohrer S., and Berger-Bachi B. Antimicrob. Agents Chemother. 47 (2003) 837
4. Filipe S.R., Pinho M.G., and Tomasz A. J. Biol. Chem. 275 (2000) 27768
5. Schneider T., Senn M.M., Berger-Bachi B., Tossi A., Sahl H.-G., and Wiedemann I. Mol. Microbiol. 53 (2004) 675
6. Ti G.S., Gaffney B.L., and Jones R.A. J. Am. Chem. Soc. 104 (1982) 1316
7. Ogilvie K.K., Beaucage S.L., Schifman A.L., Theriault N.Y., and Sadana K.L. Can. J. Chem. 56 (1978) 2768
8. Yuan C., and Wang G. Synthesis (1990) 256
9. Zemlicka J., and Chladek S. Collection Czechoslov. Chem. Commun. 34 (1969) 1007
10. Lloyd, A. J.; De Pascale, G.; Roper, D. I.; Bugg, T. D. H.; Dowson, C. G., submitted for publication, 2007.
11. Breukink E., van Heusden H.E., Vollmerhaus P.J., Swiezewska E., Brunner L., Walker S., Heck A.J., and de Kruijff B. J. Biol. Chem. 278 (2003) 19898
12. Saenger W. Principles of Nucleic Acid Structure (1983), Springer, New York pp 55-61
13. Nathans D. Nature 197 (1963) 1076