A gene defect in the promoter of the endothelial NO synthase as a risk factor for rheumatoid arthritis;Gendefekt im promoter der endothelialen NO-synthase als risikofaktor für rheumatoide arthritis

Zeitschrift fur Rheumatologie

Volumn 66, Issue 4, 2007, Pages 326-327

  Melchers, I ^a   Cattaruzza, M ^b  

^a Zentrale Klinische Forschung   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Coronary artery disease; Endothelial dysfunction; Genetics; Regulation of the immune system; Rheumatoid arthritis

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ARTICLE; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC RISK; HUMAN; PROMOTER REGION; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ARTHRITIS, RHEUMATOID; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; PROMOTER REGIONS (GENETICS); RISK ASSESSMENT; RISK FACTORS;

EID: 34447324634     PISSN: 03401855     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00393-007-0178-0     Document Type: Article

References (5)

1. Cattaruzza M, Slodowski W, Stojakovic M et al. (2003) Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells. J Biol Chem 278: 37874-37880
2. Cattaruzza M, Guzik TJ, Slodowski W et al. (2004) Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. Circ Res 95: 841-847
3. Klareskog L, Padyukov L, Rönnelid J, Alfredsson L (2006) Genes, environment and immunity in the development of rheumatoid arthritis. Curr Opin Immunol 18: 650-655
4. -786C/T single-nucleotide polymorphism in the promoter of the gene for endothelial nitric oxide synthase: insensitivity to physiological stimuli as a risk factor for rheumatoid arthritis. Arthritis Rheum 54: 3144-3151
5. Seidel W, Hecker M, Wagner U, Häntzschel H (2006) Rheumatoide Arthritis und kardiovaskuläre Komplikationen. Z Rheumatol 65: 482-486