Fatal Ricin Toxicosis in a Puppy Confirmed by Liquid Chromatography/Mass Spectrometry when Using Ricinine as a Marker

Journal of Veterinary Diagnostic Investigation

Volumn 19, Issue 2, 2007, Pages 216-220

  Mouser, Pamela ^a   Filigenzi, Michael S ^b   Puschner, Birgit ^b   Johnson, Valerie ^c   Miller, Margaret A ^a   Hooser, Stephen B ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c North Judson/San Pierre Veterinary Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANIS FAMILIARIS; RICINUS COMMUNIS;

RICIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CASE REPORT; DOG; DOG DISEASE; FEMALE; INTESTINE MUCOSA; INTOXICATION; JEJUNUM; LIVER; NECROSIS; PATHOLOGY;

ANIMALS; DOG DISEASES; DOGS; FEMALE; INTESTINAL MUCOSA; JEJUNUM; LIVER; NECROSIS; POISONING; RICIN;

EID: 34447321097     PISSN: 10406387     EISSN: 19434936     Source Type: Journal    
DOI: 10.1177/104063870701900217     Document Type: Article

References (18)

1. Albretsen JC,Gwaltney-Brant SM,Khan SA.Evaluation of castor bean toxicosis in dogs: 98 cases.J Am Anim Hosp Assoc. 2000;36:229-233.
2. Audi J,Belson M,Patel M, et al.Ricin poisoning: A comprehensive review.J Am Med Assoc. 2005;294:2342-2351.
3. Burrows GE,Tyrl RJToxic plants of North America. Ames, IA: Iowa State University Press; 2001:482-486.
4. Biological and chemical terrorism: Strategic plan for preparedness and response.Morb Mortal Wkly Rep. 2000;49:1-14.
5. Darby SM,Miller ML,Allen RO.Forensic determination of ricin and the alkaloid marker ricinine from castor bean extracts.J Forensic Sci. 2001;46:1033-1042.
6. Dobereiner J,Tokarnia CH,Canella CFC.Experimental poisoning of cattle by the pericarp of the fruit of Ricinus communis.Pesq Vet Bras. 1981;1:95-97.
7. Ferraz AC,Angelucci ME,Da Costa ML, et al.Pharmacological evaluation of ricinine, a central nervous system stimulant isolated from Ricinus communis.Pharmacol Biochem Behav. 1999;63:367-375.
8. Ferraz AC,Pereira LF,Ribeiro RL, et al.Ricinine-elicited seizures. A novel chemical model of convulsive seizures.Pharmacol Biochem Behav. 2000;65:577-583.
9. Geary T.Castor bean poisoning.Vet Rec. 1950;62:472-473.
10. Jensen WI,Allen JP.Naturally occurring and experimentally induced castor bean (Ricinus communis) poisoning in ducks.Avian Dis. 1981;25:184-194.
11. Johnson RC,Lemire SW,Woolfitt AR, et al.Quantification of ricinine in rat and human urine: A biomarker for ricin exposure.J Anal Toxicol. 2005;29:149-155.
12. Knight MW,Dorman DC.Selected plant concerns in small animals.Vet Med. 1997;92:260-272.
13. de Rezende AM Langenegger,Tokarnia CH,Dobereiner J.Experimental poisoning of rabbits with pericarp of the fruit of Ricinus communis (castor oil bean).Pesq Vet Bras. 1981;1:141-144.
14. Milewski LM,Khan SA.An overview of potentially life-threatening poisonous plants in dogs and cats.J Vet Emerg Crit Care. 2006;16:25-33.
15. Palatnick W,Tenenbein M.Hepatotoxicity from castor bean ingestion in a child.J Toxicol Clin Toxicol. 2000;38:67-69.
16. Ramsden CS,Drayson MT,Bell EB.The toxicity, distribution and excretion of ricin holotoxin in rats.Toxicology. 1989;55:161-171.
17. Rauber A,Heard J.Castor bean toxicity re-examined: A new perspective.Vet Hum Toxicol. 1985;27:498-502.
18. Soto-Blanco B,Sinhorini IL,Gorniak SL,Schumaher-Henrique B.Ricinus communis cake poisoning in a dog.Vet Hum Toxicol. 2002;44:155-156.