Dissecting the catalytic mechanism of a plant β-d-glucan glucohydrolase through structural biology using inhibitors and substrate analogues

Carbohydrate Research

Volumn 342, Issue 12-13, 2007, Pages 1613-1623

  Hrmova, Maria ^a   Fincher, Geoffrey B ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Conventional and time resolved Laue X ray crystallography; Domain movements; Mechanism based Inhibitors; Substrate analogues; Transition state mimics

Indexed keywords

DOMAIN MOVEMENTS; SUBSTRATE ANALOGUES; TIME RESOLVED LAUE X-RAY CRYSTALLOGRAPHY; TRANSITION STATE MIMICS;

BIOCATALYSTS; CELL MEMBRANES; CRYSTAL STRUCTURE; ENZYME INHIBITION; MOLECULAR MODELING; NUCLEOPHILES; OLIGOSACCHARIDES;

ENZYME ACTIVITY;

(1-2)BETA DEXTRO GLUCOSIDASE; (1-3)BETA DEXTRO GLUCOSIDASE; (1-4)BETA DEXTRO GLUCOSIDASE; (1-6)BETA DEXTRO GLUCOSIDASE; BETA DEXTRO GLUCAN GLUCOHYDROLASE; CELLOBIOSIDE; ENZYME INHIBITOR; GLUCOSIDASE; LAMINARIBIOSIDE; OLIGOSACCHARIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

CARBOHYDRATE ANALYSIS; CATALYSIS; CELL WALL; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MOLECULAR MODEL; PRIORITY JOURNAL; REVIEW; X RAY CRYSTALLOGRAPHY;

CARBOHYDRATE CONFORMATION; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLUCANS; GLUCOSIDASES; MODELS, MOLECULAR; PLANT PROTEINS; PLANTS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EMBRYOPHYTA; HORDEUM;

EID: 34447313923     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2007.05.013     Document Type: Review

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