The F1-ATPase inhibitor Inh1 (IF1) affects suppression of mtDNA loss-lethality in Kluyveromyces lactis

FEMS Yeast Research

Volumn 7, Issue 5, 2007, Pages 665-674

  Clark Walker, George Desmond ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Disruption of INH1; Interaction of Inh1 with F1; Kinetic parameters of F1 ATPase; Suppression of o lethality

Indexed keywords

ADENOSINE TRIPHOSPHATE; ETHIDIUM BROMIDE; MITOCHONDRIAL DNA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE INHIBITOR; ATPASE INHIBITORY PROTEIN; ENZYME INHIBITOR; PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ALLELE; ALPHA CHAIN; BETA CHAIN; CONFERENCE PAPER; CONTROLLED STUDY; FUNGAL STRAIN; GENETIC ANALYSIS; HYDROLYSIS; KLUYVEROMYCES; LETHALITY; NONHUMAN; PROTEIN INTERACTION; AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE REPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; KINETICS; METABOLISM; MITOCHONDRION; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE;

KLUYVEROMYCES LACTIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BASE SEQUENCE; DNA, MITOCHONDRIAL; ENZYME INHIBITORS; KINETICS; KLUYVEROMYCES; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MUTATION; PROTEINS; PROTON-TRANSLOCATING ATPASES; SUPPRESSION, GENETIC;

EID: 34447304132     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2006.00201.x     Document Type: Conference Paper

References (47)

1. Abrahams JP, Leslie AG, Lutter R Walker JE (1994) Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria. Nature 370 : 621 628.
2. Boyer PD (1997) The ATP synthase - a splendid molecular machine. Annu Rev Biochem 66 : 717 749.
3. Cabezon E, Butler PJ, Runswick MJ, Carbajo RJ Walker JE (2002) Homologous and heterologous inhibitory effects of ATPase inhibitor proteins on F-ATPases. J Biol Chem 277 : 41334 41341.
4. Cabezon E, Montgomery MG, Leslie AG Walker JE (2003) The structure of bovine F1-ATPase in complex with its regulatory protein IF1. Nat Struct Biol 10 : 744 750.
5. Chen XJ Clark-Walker GD (1993) Mutations in MGI genes convert Kluyveromyces lactis into a petite-positive yeast. Genetics 133 : 517 525.
6. Chen XJ Clark-Walker GD (1995) Specific mutations in alpha- and gamma-subunits of F1-ATPase affect mitochondrial genome integrity in the petite-negative yeast Kluyveromyces lactis. EMBO J 14 : 3277 3286.
7. Chen XJ Clark-Walker GD (1996) The mitochondrial genome integrity gene, MGI1, of Kluyveromyces lactis encodes the beta-subunit of F1-ATPase. Genetics 144 : 1445 1454.
8. Chen XJ Clark-Walker GD (2000) The petite mutation in yeasts: 50 years on. Int Rev Cytol 194 : 197 238.
9. Chi TB, Choi SY Williams N (1996) The ATP synthase of Trypanosoma brucei is developmentally regulated by an inhibitor peptide. Arch Biochem Biophys 333 : 291 297.
10. Clark-Walker GD (2003) Kinetic properties of F1-ATPase influence the ability of yeasts to grow in anoxia or absence of mtDNA. Mitochondrion 2 : 257 265.
11. Clark-Walker GD, Hansbro PM, Gibson F Chen XJ (2000) Mutant residues suppressing rho(0)-lethality in Kluyveromyces lactis occur at contact sites between subunits of F(1)-ATPase. Biochim Biophys Acta 1478 : 125 137.
12. Das AM (2003) Regulation of the mitochondrial ATP-synthase in health and disease. Mol Genet Metab 79 : 71 82.
13. Dupont CH, Mazat JP Guerin B (1985) The role of adenine nucleotide translocation in the energization of the inner membrane of mitochondria isolated from rho + and rho degree strains of Saccharomyces cerevisiae. Biochem Biophys Res Commun 132 : 1116 1123.
14. Ebner E Maier KL (1977) A protein inhibitor of mitochondrial adenosine triphosphatase (F1) from Saccharomyces cerevisiae. J Biol Chem 252 : 671 676.
15. Edwards SW, Evans JB, Williams JL Lloyd D (1982) The mitochondrial adenosine triphosphatase of Acanthamoeba castellanii. Oscillatory accumulation of enzyme activity, enzyme protein and F1-inhibitor during the cell cycle. Biochem J 202 : 453 458.
16. Foury F, Roganti T, Lecrenier N Purnelle B (1998) The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett 440 : 325 331.
17. Gietz D, St Jean A, Woods RA Schiestl RH (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20 : 1425.
18. Giraud MF Velours J (1997) The absence of the mitochondrial ATP synthase delta subunit promotes a slow growth phenotype of rho- yeast cells by a lack of assembly of the catalytic sector F1. Eur J Biochem 245 : 813 818.
19. Gledhill JR Walker JE (2005) Inhibition sites in F1-ATPase from bovine heart mitochondria. Biochem J 386 : 591 598.
20. Green DW Grover GJ (2000) The IF(1) inhibitor protein of the mitochondrial F(1)F(0)-ATPase. Biochim Biophys Acta 1458 : 343 355.
21. Haffter P Fox TD (1992) Nuclear mutations in the petite-negative yeast Schizosaccharomyces pombe allow growth of cells lacking mitochondrial DNA. Genetics 131 : 255 260.
22. Hashimoto T, Negawa Y Tagawa K (1981) Binding of intrinsic ATPase inhibitor to mitochondrial ATPase - stoichiometry of binding of nucleotides, inhibitor, and enzyme. J Biochem (Tokyo) 90 : 1151 1157.
23. Hashimoto T, Yoshida Y Tagawa K (1990) Regulatory proteins of F1F0-ATPase: role of ATPase inhibitor. J Bioenerg Biomembr 22 : 27 38.
24. Hong S Pedersen PL (2002) ATP synthase of yeast: structural insight into the different inhibitory potencies of two regulatory peptides and identification of a new potential regulator. Arch Biochem Biophys 405 : 38 43.
25. Ichikawa N, Yoshida Y, Hashimoto T, Ogasawara N, Yoshikawa H, Imamoto F Tagawa K (1990) Activation of ATP hydrolysis by an uncoupler in mutant mitochondria lacking an intrinsic ATPase inhibitor in yeast. J Biol Chem 265 : 6274 6278.
26. Ichikawa N, Fukuda M, Hashimoto T Tagawa K (1998) The carboxyl-terminal region of the yeast ATPase inhibitor is indispensable for the stability of the protein in mitochondria. J Biochem (Tokyo) 124 : 886 891.
27. Klingenberg M Rottenberg H (1977) Relation between the gradient of the ATP/ADP ratio and the membrane potential across the mitochondrial membrane. Eur J Biochem 73 : 125 130.
28. Kominsky DJ, Brownson MP, Updike DL Thorsness PE (2002) Genetic and biochemical basis for viability of yeast lacking mitochondrial genomes. Genetics 162 : 1595 1604.
29. Kumar A, Agarwal S, Heyman JA et al 2002) Subcellular localization of the yeast proteome. Genes Dev 16 : 707 719.
30. Landry Y Goffeau A (1975) Physiological and genetic modifications of the expression of the yeast mitochondrial adenosine triphosphatase inhibitor. Biochim Biophys Acta 376 : 470 478.
31. Laris PC (1977) Evidence for the electrogenic nature of the ATP-ADP exchange system in rat liver mitochondria. Biochim Biophys Acta 459 : 110 118.
32. Mitchell P (1979) Keilin's respiratory chain concept and its chemiosmotic consequences. Science 206 : 1148 1159.
33. Noji H, Yasuda R, Yoshida M Kinosita K Jr. (1997) Direct observation of the rotation of F1-ATPase. Nature 386 : 299 302.
34. Norling B, Tourikas C, Hamasur B Glaser E (1990) Evidence for an endogenous ATPase inhibitor protein in plant mitochondria. Purification and characterization. Eur J Biochem 188 : 247 252.
35. Pullman ME Monroy GC (1963) A naturally occuring inhibitor of mitochondrial adenosine triphosphatase. J Biol Chem 238 : 3762 3769.
36. Rothstein RJ (1983) One-step gene disruption in yeast. Methods Enzymol 101 : 202 211.
37. Rouslin W (1983) Protonic inhibition of the mitochondrial oligomycin-sensitive adenosine 5′-triphosphatase in ischemic and autolyzing cardiac muscle. Possible mechanism for the mitigation of ATP hydrolysis under nonenergizing conditions. J Biol Chem 258 : 9657 9661.
38. Rouslin W (1991) Regulation of the mitochondrial ATPase in situ in cardiac muscle: role of the inhibitor subunit. J Bioenerg Biomembr 23 : 873 888.
39. Saraste M (1999) Oxidative phosphorylation at the fin de siecle. Science 283 : 1488 1493.
40. Satre M, de Jerphanion MB, Huet J Vignais PV (1975) ATPase inhibitor from yeast mitochondria. Purification and properties. Biochim Biophys Acta 387 : 241 255.
41. Schnaufer A, Clark-Walker GD, Steinberg AG Stuart K (2005) The F1-ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function. EMBO J 24 : 4029 4040.
42. Schouppe C, Vaillier J, Venard R, Rigoulet M, Velours J Haraux F (1999) Activation and deactivation of F0F1-ATPase in yeast mitochondria. J Bioenerg Biomembr 31 : 105 117.
43. Schwerzmann K Pedersen PL (1986) Regulation of the mitochondrial ATP synthase/ATPase complex. Arch Biochem Biophys 250 : 1 18.
44. Sickmann A, Reinders J, Wagner Y et al 2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci USA 100 : 13207 13212.
45. St-Pierre J, Brand MD Boutilier RG (2000) Mitochondria as ATP consumers: cellular treason in anoxia. Proc Natl Acad Sci USA 97 : 8670 8674.
46. Walker JE (1994) The regulation of catalysis in ATP synthase. Curr Opin Struct Biol 4 : 912 918.
47. Weber J Senior AE (1997) Catalytic mechanism of F1-ATPase. Biochim Biophys Acta 1319 : 19 58.