Roles of telomere and telomerase in the process of ginseno- side Rg1 protection against tert-butyl hydroperoxide-induced senescence in WI-38 cells

Chinese Pharmacological Bulletin

Volumn 21, Issue 1, 2005, Pages 61-66

  Zhao, Chao Hui ^a   Chen, Xiao Chun ^a   Zhu, Yuan Gui ^a   Huang, Chun ^a   Shi, Guang Bin ^a   Zeng, Yu Qi ^a   Li, Yong Kun ^a   Peng, Xiao Song ^a   Jin, Jian Sheng ^a   Peng, Xu ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Ginsenoside Rg1; Oxidative stress; Senescence; Telomerase; Telomere

Indexed keywords

BETA GALACTOSIDASE; GINSENOSIDE RG 1; TELOMERASE; TERT BUTYL HYDROPEROXIDE;

ARTICLE; CELL AGING; CELL CYCLE; CELL LINE; CELL ULTRASTRUCTURE; CYTOCHEMISTRY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT; SENESCENCE; SOUTHERN BLOTTING; TELOMERE;

EID: 34447299118     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Norrback KF and Roos G. Telomeres and telomerase in normal and malignant haematopoietic cells[J]. Eur J Cancer,1997,33(5): 774-80.
2. Von Zglinicki T, Saretzki G, Docke W et al. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence[J]? Exp Cell Res,1995,220(1):186-93.
3. Chinese source
4. Chinese source
5. Chinese source
6. Cristofalo VJ, Sharf BB. Cellular senescence and DNA synthesis [J]. Exp Cell Res,1973,76(2):419-27.
7. Dimri GP, Lee X, Basile G et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo[J]. Proc Natl Acad Sci USA,1995,92(20):9363-7.
8. Figueroa R, Lindenmaier H, Hergenhahn M et al. Telomere erosion varies during in vitro aging of normal human fibroblasts from young and adult donors[J]. Cancer Res,2000,60(11):2770-4.
9. Furumoto K, Inoue E, Nagao N et al. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress[J]. Life Sci,1998,63(11): 935-48.
10. Dumont P, Royer V, Pascal T et al. Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence[J]. FEBS Lett,2001,502(3):109-12.
11. Tatsuka M, Maeda M, Ota T. Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh(2)[J]. Jpn J Cancer Res,2001,92(11):1184-9.
12. Chen XC, Fang F, Zhu YG et al. Protective effect of ginsenoside Rg1 on MPP(+)-induced apoptosis in SHSY5 Y cells[J]. J Neural Transm, 2003,110(8):835-45.
13. Chen XC, Zhu YG, Zhu LA et al. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress[J]. Eur J Pharmacol,2003,473(1):1-7.
14. Masutomi K, Yu EY, Khurts S et al. Telomerase maintains telomere structure in normal human cells[J]. Cell,2003,114(2): 241-53.