The synergy site of fibronectin is required for strong interaction with the platelet integrin αiibβ3

Annals of Biomedical Engineering

Volumn 34, Issue 10, 2006, Pages 1542-1552

  Chada, Diwakar ^a   Mather, Timothy ^b   Nollert, Matthias U ^a  

^a University of Oklahoma   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Fibronectin; Platelets; Shear rate

Indexed keywords

AMINO ACID SUBSTITUTION; ASPARTIC ACIDS; BACTERIAL EXPRESSION SYSTEMS; CELL ADHESION MOLECULES; FIBRONECTIN; GLASS COVERS; INTEGRINS; OPTIMAL BINDING; PLATELET INTEGRIN; PURIFIED PROTEIN; RGD PEPTIDE; SITE DIRECTED MUTAGENESIS; STRONG INTERACTION;

AMINO ACIDS; GLYCOPROTEINS; LIGANDS; OPTIMIZATION; PEPTIDES; PHYSIOLOGY; SHEAR DEFORMATION;

PLATELETS;

FIBRINOGEN RECEPTOR; FIBRONECTIN; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ARTICLE; BINDING SITE; BIOMEDICAL ENGINEERING; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SCANNING ELECTRON MICROSCOPY; SITE DIRECTED MUTAGENESIS; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESIVENESS;

ANTIBODIES, MONOCLONAL; BINDING SITES; BIOMEDICAL ENGINEERING; BLOOD PLATELETS; FIBRONECTINS; HUMANS; MICROSCOPY, ELECTRON, SCANNING; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

EID: 34447296265     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-006-9161-1     Document Type: Article

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