Nonimmediate reactions to betalactams

Current Opinion in Allergy and Clinical Immunology

Volumn 7, Issue 4, 2007, Pages 310-316

  Lopez, Soledad ^a   Blanca Lopez, Natalia ^b   Cornejo Garcia, Jose Antonio ^a   Canto, Gabriela ^b   Torres, Maria Jose ^a   Mayorga, Cristobalina ^a   Blanca, Miguel ^a  

^a HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

lactams; Immunological response; In vitro test; In vivo test; Nonimmediate reaction

Indexed keywords

AMINOPENICILLIN; AMOXICILLIN; BETA LACTAM ANTIBIOTIC; CD11B ANTIGEN; CD27 ANTIGEN; CD3 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CEFACLOR; CEFTRIAXONE; CEPHALOSPORIN; CLAVULANIC ACID; CYTOKINE; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; PENICILLIN G; SULTAMICILLIN;

ANAPHYLAXIS; ANTIBIOTIC THERAPY; BABOON SYNDROME; BELGIUM; BULLOUS PEMPHIGOID; CELLULAR IMMUNITY; CONTACT DERMATITIS; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DENDRITIC CELL; DIAGNOSTIC TEST; DRUG DOSE REGIMEN; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DRUG UTILIZATION; EOSINOPHILIA; ERYTHEMA; FIXED DRUG ERUPTION; FRANCE; GREECE; HEPATITIS; HISTOPATHOLOGY; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INFECTION RISK; LYMPHOCYTE HOMING; MACULOPAPULAR RASH; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY T LYMPHOCYTE; NONHUMAN; PORTUGAL; PRIORITY JOURNAL; PROVOCATION TEST; PUSTULOSIS; REVIEW; SERUM SICKNESS; SKIN MANIFESTATION; SPAIN; STEVENS JOHNSON SYNDROME; T LYMPHOCYTE SUBPOPULATION; TOXIC EPIDERMAL NECROLYSIS; VESICULAR RASH;

ANTI-BACTERIAL AGENTS; ANTIGENS, CD; BETA-LACTAMS; CYTOKINES; DRUG ERUPTIONS; DRUG HYPERSENSITIVITY; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOLOGIC TESTS; SKIN TESTS; T-LYMPHOCYTES;

EID: 34447294221     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e3281e209fe     Document Type: Review

References (69)

1. Warbrick EV, Thomas AL, Stejkal V, Coleman J. An analysis of betalactam derived antigens on spleen cells and serum proteins by ELISA and Western blotting. Allergy 1995; 50:910-917.
2. Padovan E, Mauri-Hellweg D, Pichler WJ, Weltzien HU. T cell recognition of penicillin G: structural features determining antigenic specificity. Eur J Immunol 1996; 26:42-48.
3. Hertl M, Merck HF. Lymphocyte activation in cutaneous drug reactions. J Invest Dermatol 1995; 132:95S-98S.
4. Romano A, Blanca M, Torres MJ, et al. Diagnosis of nonimmediate reactions to beta lactams antibiotics. Allergy 2004; 59:1153-1160.
5. Roujeau JC, Kelly JP. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994; 331:1272-1285.
6. Shiohara T, Mizukawa Y, Teraki Y. Pathophysiology of fixed drug eruption: the role of skin testing. Curr Opin Allergy Clin Immunol 2002; 2:317-323.
7. Cederbrant K, Marcusson-Stahl M, Hultman P. Characterisation and primary recall: in vitro lymphocyte responses to bacampicillin in allergic subjects. Clin Exp Allergy 2000; 30:1450-1459.
8. Foti C, Bonamonte D, Trentin R, et al. Occupational contact allergy to cephalosporins. Contact Dermatitis 1997; 36:104-109.
9. Gielen K, Goosens A. Occupational allergic contact dermatitis from drug healthy healthcare workers. Contact Dermatitis 2001; 45:273-279.
10. Murray DL, Singer DA, Singer AB, Veldman JP. Cefaclor: a cluster of adverse reactions. N Engl J Med 1980; 303:1003.
11. Kearns GL, Wheeler JG, Childress SH, Letzig LG. Serum sickness-like reactions to cefaclor: role of hepatic metabolism and individual susceptibility. J Pediatrics 1994; 125:805-811.
12. Wakelin S, Sidhu S, Orton DI, et al. Amoxycillin induced flexural exanthema. Clinical Exp Dermatol 1999; 24:71-73.
13. Shimanovich I, Rose C, Sitaru C, et al. Localized linear IgA disease induced by ampicillin/sulbactam. J Am Acad Dermatol 2004; 51:95-98.
14. Nadarajah K, Green GR, Naglak M. Clinical outcomes of penicillin skin testing. Ann Allergy Asthma Immunol 2005; 95:541-555.
15. Blanca M. Allergic reactions to penicillins: a changing world? Allergy 1995; 50:777-782.
16. Bigby M, Jick S, Jick H, Arndt K. Drug-induced cutaneous reactions: a report from Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982. JAMA 1986; 256:3358-3363.
17. Aihara M, Ikezawa Z. Evaluation of the skin test reactions in patients with delayed type rash induced by penicillins and cephalosporins. J Dermatol 1987; 14:440-448.
18. Antico A, Marcotulli C. Occupational contact allergy to ceftiofur. Allergy 2003; 58:957-958.
19. Braun WP. Cephalotin allergy of the delayed type. Contact Dermatitis 1975; 1:190-191.
20. Kamphof WG, Rustermeyer T, Bruynzel DP. Sensitisation to clavuanic acid in augmentin. Contact Dermatitis 2002; 47:47.
21. Chiba Y, Takahashi S, Yamakawa Y, et al. Contact urticaria syndrome caused by patch testing with cefotiam hydrochloride. Contact Dermatitis 1999; 41:234.
22. Kannagara DW, Smith B, Cohen K. Exfoliative dermatitis during cefoxitin therapy. Arch Intern Med 1982; 142:1031-1032.
23. Gebhardt M, Lustig A, Bocker T, Wollina U. Acute generalized exanthematous pustulosis (AGEP): manifestation of drug allergy to propicillin. Contact Dermatitis 1995; 33:204-205.
24. Straube MD, Freitag M, Altmeyer P, Szliska C. Occupational airborne contact dermatitis from cefazolin. Contact Dermatitis 2000; 42:44-45.
25. Valsecchi R, Serra M, Pansera B, et al. Patch testing in adverse drug reactions to penicillin and cephalosporin. Contact Dermatitis 1981; 7:158.
26. Milligan A, Douglas WS. Contact dermatitis to cephalexin. Contact Dermatitis 1986; 15:91.
27. Bierman CW, Pierson WE, Zeitz SJ, et al. Reactions associated with ampicillin therapy. JAMA 1972; 220:1098-1100.
28. Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. Lancet 2001; 357:1851-1853.
29. Gruchalla RS, Piromhamed M. Antibiotic allergy. N Eng J Med 2006; 354:601-609.
30. LeClaire AC, Martin AG, Hoven AD. Rash associated with piperacillin/tazobactam administration in infectious mononucleosis. Ann Pharmacother 2004; 38:996-998.
31. Schnyder B, Helbling A, Kappeler A, Pichler WJ. Drug-induced papulovesicular exanthema. Allergy 1998; 53:817-818.
32. Pichler WJ. Delayed drug hypersensitivity reactions. Ann Int Med 2003; 139:683-693.
33. Britschgi M, Pichler WJ. Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells. Curr Opin Allergy Clin Immunol 2002; 2:325-331.
34. Weltzien HU, Padovan E. Molecular features of penicillin allergy. J Invest Dermatol 1998; 110:203-206.
35. Hertl M, Geisel J, Boecker C, Merk HF. Selective generation of CD8+ T-cell clones from the peripheral blood of patients with cutaneous reactions to beta-lactam antibiotics. Br J Dermatol 1993; 128:619-626.
36. Hertl M, Bohlen H, Jugert F, et al. Predominance of epidermal CD8+ T lymphocytes in bullous cutaneous reactions caused by beta-lactam antibiotics. J Invest Dermatol 1993; 101:794-799.
37. Brugnolo F, Annunziato F, Sampognaro S, et al. Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with adverse drug reactions. J Immunol 1999; 163:1053-1059.
38. Mauri-Hellweg D, Bettens F, Mauri D, et al. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J Immunol 1995; 155:462-472.
39. Rodriguez-Pena R, Lopez S, Mayorga C, et al. Potential involvement of dendritic cells in delayed hypersensitivity reactions to B-lactams. J Allergy Clin Imunol 2006; 118:949-956.
40. Cella MF, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997; 9:10-16.
41. Aiba S, Manome H, Yoshino Y, Tagami H. In vitro treatment of human transforming growth factor-beta1-loaded monocyte-derived dendritic cells with haptens can induce the phenotypic and functional changes similar to epidermal Langerhans cells in the initiation phase of allergic contact sensitivity reaction. Immunology 2000; 101:68-75.
42. Hausermen P, Bircher AJ. Immediate and delayed hypersensitivity to ceftriaxone and anaphylaxis to intradermal testing with other beta lactam antibiotics, in a previously amoxicillin sensitised patient. Contact Dermatitis 2002; 47:311-312.
43. Romano A, De Santis A, Romito A, et al. Delayed hypersensitivity to aminopenicillins is related to major histocompatibility complex genes. Ann Allergy Asthma Immunol 1998; 80:433-437.
44. Tatum AJ, Ditto AM, Patterson R. Severe serum sickness-like reaction to oral penicillin drugs: three cases reports. Ann Allergy Asthma Immunol 2001; 86:330-334.
45. Mayorga C, Pena RR, Blanca-Lopez N, et al. Monitoring the acute response in non immediate allergic drug reactions. Curr Opin Allergy Clin Immunol 2006; 6:249-257. A review that focuses on the monitorization of nonimmediate allergic drug reactions at the acute phase and the resolution period. A number of different cytotoxic mediators and additional molecules are expressed by T cells that became regulated after the resolution of the disease.
46. Torres MJ, Mayorga C, Fernandez T, et al. T cell assessment in allergic drug reactions during acute phase according to time of occurrence. Int J Immunopathol Pharmacol 2006; 19:119-129.
47. Gonzalez FJ, Carvajal MJ, Leyva L, et al. Expression of the cutaneous lymphocyte-associated antigen in circulating T cells in drug-allergic reactions. Int Arch Allergy Immunol 1997; 113:345-347.
48. Blanca M, Leyva L, Torres MJ, et al. Memory to the hapten in nonimmediate cutaneous allergic reactions to betalactams resides in a lymphocyte subpopulation expressing both CD45RO and CLA markers. Blood Cells Mol Dis 2003; 31:75-79.
49. Torres MJ, Blanca M, Fernandez J, et al. Diagnosis of immediate hypersensitivity reactions to betalactams. Allergy 2003; 58:961-972.
50. Barbaud A, Tréchot P, Reichert-Penetrat S, et al. Relevance of skin tests with drugs in investigating cutaneous adverse drug reactions. Contact Dermatitis 2001; 45:265-268.
51. Torres MJ, Padial A, Fuentes MS, et al. The role of skin and drug provocation tests in the diagnosis of patients with nonimmediate allergic reactions to betalactams. In: Abstract book of the XXIII European Academy of Allergology and Clinical Immunology Congress; Amsterdam; 2004. p. 325.
52. Oswa J, Naitu S, Aihara M, et al. Evaluation of skin tests reactions in patients with non immediate type drug eruptions. J Dermatol 1990; 17:235-239.
53. Terrados S, Blanca M, Garcia J, et al. Nonimmediate reactions to betalactams: prevalence and role of the different penicillins. Allergy 1995; 50:563-567.
54. Romano A, Vola M, Modino C, et al. Diagnosis of non immediate reactions to penicillins by in vivo tests. Int Arch Allergy Immunol 2002; 129:169-174.
55. Barbaud A, Reichert-Penetrat S, Tréchot P, et al. The use of skin testing in the investigation of cutaneous adverse drug reactions. Br J Dermatol 1998; 139:49-58.
56. Torres MJ, Sanchez-Sabatè E, Alvarez J, et al. Skin tests evaluation in non immediate reactions to penicillins. Allergy 2004; 59:219-224.
57. Luque I, Leyva L, Torres MJ, et al. In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions. Allergy 2001; 56:611-618.
58. Stejskal VDM, Forsbeck M, Olin R. Side chain specific lymphocyte responses in workers with occupational allergy induced by penicillins. Int Archs Allergy Appl Immunol 1987; 82:261-264.
59. De Haan P. Induction of benzylpenicilloyl specific antibodies, inducing IgE by long term administration of benzylpenicillin. Clin Allergy 1983; 13:563-569.
60. Brander C, Mauri-Helweg D, Rolli HP, et al. Heterogeneous T cell response to betalactam modified self structures in penicillin allergic individuals. J Immunol 1995; 155:2670-2678.
61. Torres MJ, Gonzalez FJ, Mayorga C, et al. IgG and IgE antibodies in subjects allergic to penicillins recognise different parts of the penicillin molecule. Int Arch Allergy Immunol 1997; 113:342-344.
62. Hari Y, Frutig-Schnyder K, Hurni M, et al. T cell involvement in cutaneous drug eruptions. Clin Exp Allergy 2001; 31:1398-1408.
63. Villada G, Roujeau JC, Clerici T, et al. Immunopahtology of toxic epidermal necrolysis. HLA-DR expression, Langerhans cells, and mononuclear cells: an immunopathologic study of five cases. Arch Dermatol 1992; 128:50-53.
64. Tapias B, Padial A, Sanchez-Sabate E, et al. Involvement of CCL-CCR10 interactions in drug induced cutaneous reactions. J Allergy Clin Immunol 2004; 114:33-40.
65. Sumiyoshi Y, Akashi K, Kikuchi M. Detection of human virus 6 (HHV6) in the skin of a patient with primary HHV 6 infection and erythroderma. J Clin Pathol 1994; 47:762-763.
66. Brown HA, Macon WR, Kurtin PJ, Gibson LE. Cutaneous involvement by anioimmunoblastic T-cell lymphoma with remarkable heterogenous Epstein-Barr virus expression. J Cutan Pathol 2001; 28:432-438.
67. Lee CE, Zembower TR, Fotis MA, et al. The incidence of antimicrobial allergies in hospitalised patients: implications regarding prescribing patterns and emerging bacterial resistance. Arch Int Med 2000; 160:2819-2822.
68. Berstein I, Gruchalla RS, Lee R, et al. Executive summary of disease management of drug hypersensitivity: a practice parameter. Ann Allergy Asthma Immunol 1999; 83:665-700.
69. Aberer W, Bircher A, Romano A, et al. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations. Allergy 2003; 58:854-863.