The ethical involvement of women in HIV vaccine trials in Africa: Discussion paper developed for the African AIDS vaccine programme

Women and Health

Volumn 45, Issue 1, 2007, Pages 37-50

  Wassenaar, Douglas R ^a   Barsdorf, Nicola W ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Africa; Ethics; HIV; Vaccine trials; Vulnerable; Women

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AFRICA; ARTICLE; CLINICAL TRIAL; CULTURAL FACTOR; DISEASE TRANSMISSION; ETHICS; ETHNOLOGY; FEMALE; HUMAN; MALE; PATIENT ATTITUDE; PATIENT SELECTION; WOMEN'S HEALTH; WOMEN'S RIGHTS;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AFRICA, SOUTHERN; AIDS VACCINES; CLINICAL TRIALS; CULTURAL CHARACTERISTICS; FEMALE; HUMANS; MALE; PATIENT ACCEPTANCE OF HEALTH CARE; PATIENT SELECTION; WOMEN'S HEALTH; WOMEN'S RIGHTS;

EID: 34447293488     PISSN: 03630242     EISSN: 15410331     Source Type: Journal    
DOI: 10.1300/J013v45n01_03     Document Type: Article

References (44)

1. Abdool Karim, Quarraisha. 2004. Women and AIDS: Epidemiology and gender barriers to prevention in KwaZulu-Natal, South Africa. Paper presented at the XV International AIDS Conference, July 11-16, in Bangkok, Thailand.
2. Abdool Karim, Salim., Quarraisha Abdool Karim and Cheryl Baxter. 2005. Overview of the book. In Salim Abdool Karim and Quarraisha Abdool Karim (eds.), HIV/AIDS in South Africa, pp. 37-47. Cambridge: Cambridge University Press.
3. African AIDS Vaccine Programme (AAVP) 2006. The African AIDS Vaccine Programme: About us. http://www.who.int/vaccine_research/diseases/hiv/ aavp/en/ (accessed October 19, 2006).
4. Alvarado, Reynaldo, Ana Zepeda, Soledad Rivero, Nieves Rico, Susana López and Soledad Díaz. 1999. Integrated maternal and infant health care in the postpartum periodin a poor neighborhood in Santiago, Chile. Studies in Family Planning, 30: 133.
5. Barnett, Tony and Alan Whiteside, (eds.). 2002. AIDS in the twenty-first century: Disease and globalization. New York: Palgrave.
6. Barsdorf, Nicola and Douglas Wassenaar. 2005. Racial differences in public perceptions of voluntariness of medical research participants in South Africa. Social Science and Medicine 60: 1087-1098.
7. Bass, Emily and Richard Jeffreys. 2001. Women and HIV in Kenya: An interview with Dorothy Mbori-Ngacha. IAVI Report 5, no. 8:7-8. http://www.aegis.com/pubs/iavi/2001/IAVI2001-0705.html (accessed April 3, 2005).
8. Bass, Emily. 2001. Special report: Women and AIDS vaccines. IAVI Report 5, no. 8: 1-2, http://www.aegis.com/pubs/iavi/2001/ IAVI2001-0701.html (accessed March 16, 2005).
9. Cleland, John and Mohamed M Ali. 2006. Sexual abstinence, contraception, and condom use by young African women: A secondary analysis of survey data. Lancet 368:1788-1793.
10. d'Adesky, Anne-Christine. 2001. Gender, HIV transmission and vaccines: A moving target. IAVI Report 5, no. 8: 18-20. http://www.aegis.com/pubs/iavi/2001/IAVI2001-0711.html (accessed March 16, 2005).
11. Dionisio, Daniele, Yunzhen Cao, Lu Hongzhou, Krisana Kraisintu and Daniela Messeri. 2006. Affordable antiretroviral drugs for the under-served markets: How to expand equitable access against the backdrop of challenging scenarios? Current HIV Research 4: 3-20.
12. Dunkle, Kristin, Rachel Jewkes, Heather Brown, Glenda Gray, James McIntryre and Siobán Harlow. 2004. Gender-based violence, relationship power, and risk of HIV infection among women attending antenatal clinics in South Africa. Lancet 363: 1415-1421.
13. Fowler, Mary, Sandra Melnick and Bonnie Mathieson. 1997. Women and HIV: Epidemiology and global overview. Obstetrics and Gynecology Clinics of North America 24:705-729.
14. Gray, Glenda. Progress at the Chris Hani-Baragwanath HIV vaccine trial site. Personal communication (October 19, 2006).
15. Gupta, Geeta. 2001. Editorial: How men's power over women fuels the HIV epidemic. British Medical Journal 324: 183-184.
16. Gupta Geeta. 2005. Luncheon remarks on women and AIDS. Paper presented at the Interaction Forum, June 2, in Washington D.C., U.S.A.
17. Hartwig, Kari. 2004. The global women and AIDS agenda: Are we moving forward? Harvard Health Policy Review 5: 70-76.
18. Jaspan, Heather, Jessica Berwick, Landon Myer, Catherine Mathews, Alan Flisher, Robin Wood and Linda-Gail Bekker. 2006. Adolescent HIV prevalence, sexual risk, and willingness to participate in HIV vaccine trials. Journal of Adolescent Health 39: 642-648.
19. Jeffreys, Richard. 2001. Closing in on the immune protection in the women of Pumwani: Can a cohort of Kenyan sex workers help guide us towards an AIDS vaccine? IAVI Report 5, no. 8: 9-14. http://www.aegis.com/pubs/iavi/2001/IAVI2001-0706.html (accessed March 15, 2005).
20. Kapoor, Sushma. 2004. Gender considerations in AIDS vaccine trials. (Available from Sushma Kapoor at IAVI, 110 William Street, 27th floor, NY 10038, or skapoorιavi.org)
21. Labonte, Ronald, Ted Schrecker and Amit Sen Gupta. 2005. A global health equity agenda for the G8 summit. British Medical Journal 330: 533-536.
22. Leclerc-Madlala, Suzanne. 2001. Science, AIDS and sexual culture in Africa. Women's International Network News 27, no. 1: 20-22, http://www.looksmartsavings.com/p/articles/mi_m2872/ is_1_27/ai_71563341 (accessed August 25, 2004).
23. Lee, Sabrina. 2004. Women's vulnerability to HIV/AIDS in informal trading environments in Uganda and South Africa. HEARD Quarterly Newsletter 11: 3. Durban: HEARD.
24. Mawa, Stephen, Fred Wabwire-Mangen, Hannah Kibuuka, Monica Millard, Betty Nanzigu and Merlin Robb. 2005. Challenges and lessons learnt from HIV vaccine trials recruitment in Uganda. Paper presented at the AIDS Vaccine Conference, September 6-9, in Montreal, Canada.
25. Mills, Edward, Stephanie Nixon, Sonal Singh, Sonam Dolma, Anjali Nayyar and Sushma Kapoor. 2006. Enrolling women into HIV preventive vaccine trials: An ethical imperative but a logistical challenge. Public Library of Science Medicine 3(3): E94.
26. Molyneux, Catherine, Douglas Wassenaar, Norbert Peshu and Kevin Marsh. 2005. Community voices on the notion and practice of informed consent for biomedical research. Social Science and Medicine 61: 1463-1473.
27. Pool Konde, Carol, Annet Nanvubya, Frederick Nakwagala, Emmanuel Mugisha, Simon Sigirenda, Leslie Nielsen, Pontiano Kaleebu, Monica Balyeku, Sarah Coutinho and Claudia Schmidt. 2005. Challenges of counseling and educating volunteers in a Phase 1 HIV vaccine trial in Uganda. Paper presented at the AIDS Vaccine Conference, September 6-9, in Montreal, Canada.
28. Ramjee, Gita. (2000). Reducing women's risk of HIV infection: South Africa's contribution to microbicide research and development. South African Journal of Science 96: 280-285.
29. SAPA. 2005. AIDS "carries the face of a woman." Mail and Guardian March 20.
30. Segal, Marian. 1993. Women and AIDS. FDA Consumer.
31. Shisana, Olive. 2004. Gender and HIV/AIDS: Focus on Southern Africa. Paper presented at the Inaugural International Institute on Gender and HIV/AIDS, June 7, in Durban, South Africa.
32. Ssekubugu, Robert, Francis Masiye, Caroline Kithinji, Adnan Hyder and Nancy Kass. 2006. The female condom, society and public health: A commentary from Sub-Saharan Africa. Organizational Ethics 3: 64-72.
33. Taha E. Taha, Samah Nour, Newton Kumwenda, Robin Broadhead, Susan Fiscus, George Kafulafula, Chiwawa Nkhoma, Shu Chen and Donald Hoover. 2005. Gender differences in perinatal HIV acquisition among African infants. Pediatrics 2: 167-172.
34. Tucker, Tim, e-mail message to author, October 3, 2006.
35. UNAIDS. 2000a. Ethical considerations in HIV preventive vaccine research. Geneva: Author.
36. UNAIDS. 2000b. Report on the global HIV/AIDS epidemic. Geneva: Author.
37. UNAIDS. 2005a. Report on the global HIV/AIDS epidemic. Geneva: Author.
38. UNAIDS. 2005b. Towards creating effective partnerships for the conduct of HIV prevention trials. Presented at the UNAIDS Southern and Eastern African regional consultation, April 24-26, in Durban, South Africa.
39. UNAIDS. 2006. Report on the global HIV/AIDS epidemic. Geneva: Author.
40. Van Der Vliet, Virginia. 1999. Attacking AIDS in Uganda. South African AIDS Information Dissemination Service Bulletin 7: 11, http://www.safaids.org.zw/publications/1999%20Vol%207%20No%201.pdf (accessed June 30, 2004).
41. Wassenaar, Douglas, Nicola Barsdorf and Linda Richter. 2005. Gender and HIV vaccine trials: Ethics and social science issues. Harvard Health Policy Review 6: 124-130, http://www.hcs.harvard.edu/~epihc/ currentissue/spring2005/wassenaar.pdf (accessed May 29, 2006).
42. Wilkinson, David, Salim Abdool Karim, Abigail Harrison, Mark Lurie, Mark Colvin, Cathy Connolly and A Willem Sturm. 1999. Unrecognised sexually transmitted infections in rural South African women: A hidden epidemic. Bulletin of the World Health Organisation 77: 22-28.
43. World Health Organisation. 2004. The world health report: Changing history. Geneva: Author.
44. Zungu-Dirwayi, Nompumelelo, Olive Shisana, Eric Udjo, Thabang Mosala and John Seager. 2004. An audit of HIV/AIDS policies in Botswana, Lesotho, Mozambique, South Africa, Swaziland and Zimbabwe. Cape Town: Human Sciences Research Council.