Pinealectomy reduces hepatic and muscular glycogen content and attenuates aerobic power adaptability in trained rats

Journal of Pineal Research

Volumn 43, Issue 1, 2007, Pages 96-103

  Borges Silva, Cristina Das Neves ^a   Takada, Julie ^a   Alonso Vale, Maria Isabel Cardoso ^a   Peres, Sidney B ^a   Fonseca Alaniz, Miriam H ^a   Andreotti, Sandra ^a   Cipolla Neto, Jose ^a   Pithon Curi, Tania C ^a   Lima, Fabio Bessa ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Adipose tissue; Endurance; Maximal oxygen uptake; Melatonin; Pinealectomy; Training

Indexed keywords

CITRATE SYNTHASE; GLUCOSE; GLYCOGEN; HEXOKINASE; INSULIN; LACTATE DEHYDROGENASE; MALATE DEHYDROGENASE (DECARBOXYLATING); OXYGEN; PYRUVATE KINASE;

ADAPTATION; ADIPOCYTE; ADIPOSE TISSUE; AEROBIC EXERCISE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; BLOOD SAMPLING; CALORIMETRY; CARBOHYDRATE METABOLISM; CELL SIZE; CONTROL GROUP; CONTROLLED STUDY; ENDURANCE; ENERGY METABOLISM; ENZYME ACTIVITY; EPIDIDYMIS; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; GLYCOGEN MUSCLE LEVEL; HOMEOSTASIS; INSULIN BLOOD LEVEL; LIVER; MALE; MUSCLE TISSUE; NONHUMAN; OXYGEN CONSUMPTION; PINEAL BODY; PINEALECTOMY; RAT; TRAINING; WISTAR RAT;

ANIMALS; GLYCOGEN; LIVER; MALE; MUSCLES; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; PINEAL GLAND; RATS; RATS, WISTAR;

EID: 34447293045     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2007.00450.x     Document Type: Article

References (56)

1. Reiter RJ. The ageing pineal gland and its physiological consequences. Bio Essays 1992 14 : 169 175.
2. Diaz B, Blazquez E. Effect of pinealectomy on plasma glucose, insulin and glucagon levels in the rat. Horm Metabol Res 1986 18 : 225 229.
3. Lima FB, Machado UF, Bartol I et al. Pinealectomy causes glucose intolerance and decreases adipose cell responsiveness to insulin in rats. Am J Physiol (Endocrinol Metab 38) 1998 275 : E934 E941.
4. Vazan R, Beder I, Styk J. Melatonin and the heart. Cesk Fysiol 2004 53 : 29 33.
5. Hagerman FC. Energy metabolism and fuel utilization. Med Sci Sports Exerc 1992 24 : S309 S314.
6. Mazepa RC, Cuevas MJ, Collado PS et al. Melatonin increases muscle and liver glycogen content in nonexercised and exercised rats. Life Sci 2000 66 : 150 160.
7. Slentz CA, Gulve EA, Rodnick KJ et al. Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol 1992 73 : 486 492.
8. Nakatani A, Han D-H, Hansen PA et al. Effect of endurance exercise training on muscle glycogen supercompensation in rats. J Appl Physiol 1997 82 : 711 715.
9. Saitoh S, Shimomura Y, Tasaki Y et al. Effect of short-term exercise training on muscle glycogen in resting conditions in rats fed a high fat diet. Eur J Appl Physiol 1992 64 : 62 67.
10. Hoffman RA, Reiter RJ. Rapid pinealectomy in hamsters and other small rodents. Anat Rec 1965 153 : 19 22.
11. Rodbell M. Metabolism of isolated fat cells. Effects of hormones on glucose metabolism and lipids. J Biol Chem 1964 239 : 357 380.
12. Negrao CE, Moreira ED, Santos Mcl et al. Vagal function impairment after exercise training. J Appl Physiol 1992 72 : 1749 1753.
13. Dufloth DL, Morris M, Michelini LC. Modulation of exercise tachycardia by vasopressin in the nucleus tractus solitarii. Am J Physiol Regul Integr Comp Physiol 1997 42 : R1271 R1282.
14. Leek BT, Mudaliar Srd, Henry R et al. Effect of acute exercise on citrate synthase activity in untrained and trained human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 2001 280 : R441 R447.
15. Borges-Silva CN, Alonso-Vale Mic, Franzoi-DE-Moraes SM et al. Pinealectomy impairs adipose tissue adaptability to exercise in rats. J Pineal Res 2005 38 : 278 283.
16. Leveille GA, Chakrabarty R. Diurnal variations in tissue glycogen and liver weight of meal-fed rats. J Nutr 1967 93 : 546 554.
17. Crabtree B, Leech AR, Newsholme EA. Measurement of enzyme activities in crude extracts of tissues. In : Techniques in Metabolic Research. Pogson C, ed. Elsevier, Amsterdam, 1979 pp. 1 37.
18. Zammit VA, Newsholme EA. The maximum activities of hexokinase, phosphorylase, phosphofructokinase, glycerol phosphates dehydrogenases, lactate dehydrogenase, octopine dehydrogenase, phosphoenolpyruvate carboxykinase, nucleoside diphosphatekinase, glutamate-oxaloacetate transaminase and arginine kinase in relation to carbohydrate utilization in muscle from marine invertebrates. Biochem J 1979 160 : 447 462.
19. Alp PR, Newsholme EAA, Zammit VA. Activities of citrate synthase and NAD+-LINKED and NADP+- linked isocitrate dehydrogenase in muscle from vertebrates in invertebrates. Biochem J 1976 154 : 689 700.
20. Newsholme EA, Williams T. The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle. Biochem J 1978 176 : 623 626.
21. Nagano M, Ishibachi H, Mccully V, Cottam GL. Epinephrine-stimulated phosphorylation of pyruvate kinase in hepatocytes. Arch Biochem Biophys 1980 203 : 271 281.
22. Lott JA, Turner K. Evaluation of Trinder's glucose oxidase method for measuring glucose in serum and urine. Clin Chem 1975 21 : 1754 1760.
23. Legaz AA, Serrano OE, Jcasajus MJA et al. The changes in running performance and maximal oxygen uptake after long-term training in elite athletes. J Sports Med Phys Fitness 2005 45 : 435 440.
24. Plank DM, Hipp MJ, Mahon AD. Aerobic exercise adaptations in trained adolescent runners following a season of cross-country training. Res Sports Med 2005 13 : 273 286.
25. Ekblom B, Astrand PO, Saltin B, Stenberg J et al. Effect of training on circulatory response to exercise. J Appl Physiol 1968 24 : 518 528.
26. Robinson DM, Ogilvie RW, Tullson PC et al. Increased peak oxygen consumption of trained muscle requires increased electron flux capacity. J Appl Physiol 1994 77 : 1941 1952.
27. Cooper CE, Vollahard NB, Choveiri T et al. Exercise, free radicals and oxidative stress. Biochem Soc Trans 2002 30 : 280 285.
28. Reiter RJ, Tan DX, Maldonado MD. Melatonin as a antioxidant: physiology versus pharmacology. J Pineal Res 2005 32 : 215 216.
29. Alonso M, Collago PS, Gonzalez-Gallego J. Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. J Pineal Res 2006 41 : 8 14.
30. Leon J, Acuna-Castroviejo D, Escames G et al. Melatonin mitigates mitochondrial malfunction. J Pineal Res 2005 38 : 1 9.
31. Baydas G, Gursu MF, Yilmaz S et al. Daily rhythm of glutathione peroxidase activity, lipid peroxidation and glutathione levels in tissues of pinealectomized rats. Neurosci Lett 2002 323 : 195 198.
32. Hara M, Abe M, Suzuki T et al. Tissue changes in glutathione metabolism and lipid peroxidation induced by swimming are partially prevented by melatonin. Pharmacol Toxicol 1996 5 : 308 312.
33. Mackie BG, Terjung RL. Influence of training on blood flow to different skeletal muscle fiber types. J Appl Physiol 1983 55 : 1072 1078.
34. Hambrecht R, Fiehn E, Weigl C et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998 98 : 2709 2715.
35. Lash JM, Bohlen HG. Functional adaptations of rat skeletal muscle arterioles to aerobic exercise training. J Appl Physiol 1992 72 : 2052 2062.
36. Delp MD. Effects of exercise training on endothelium dependent peripheral vascular responsiveness. Med Sci Sports Exercise 1995 27 : 1152 1157.
37. Oltman CL, Parker JL, Adams HR et al. Effects of exercise training on vasomotor reactivity of porcine coronary arteries. Am J Physiol 1992 32 : H372 H382.
38. Chuang JI, Chen SS, Lin MT. Melatonin decreases brain serotonin release, arterial pressure and heart rate in rats. Pharmacology 1993 47 : 91 97.
39. Holmes SW, Sugden D. The effect of melatonin on pinealectomy-induced hypertension in the rat. Br J Pharmacol 1976 56 : 360 361.
40. Kawashima K, Miwa Y, Fujimoto K et al. Antihypertensive action of melatonin in the spontaneously hypertensive rat. Clin Exp Theo Pract 1987 A9 : 1121 1131.
41. Weekley LB. Effects of melatonin on isolated pulmonary artery and vein: role of vascular endothelium. Pulm Pharmacol 1993 6 : 149 154.
42. Weekley LB. Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. J Pineal Res 1991 11 : 28 34.
43. Viswanathan M, Hissa R, George JC. Suppression of sympathetic nervous system by short photoperiod and melatonin in the Syrian hamster. Life Sci 1986 38 : 73 79.
44. Viswanathan M, Laitinen JT, Saavedra JM. Expression of melatonin receptors in arteries involved in thermoregulation. Proc Natl Acad Sci U S A 1990 87 : 6200 6203.
45. Capsoni S, Stankov BM, Fraschini F. Reduction of regional cerebral blood flow by melatonin in young rats. Neuroreport 1995 6 : 1346 1348.
46. Mustonen AM, Nieminen P, Hyvarinen H. Effect of continuous light and melatonin treatment on energy metabolism of the rat. J Endocrinol Invest 2002 25 : 716 723.
47. Delahunty G, Olcese J, Vlaming V. Photoperiod effects on carbohydrate metabolites in the goldfish, Carassius auratus: role of the pineal and retinal pathways. Rev Can Biol 1980 39 : 173 180.
48. Alonso-Vale MIC, Borges-Silva CN, Anhe GF et al. Light/dark cycle-dependent metabolic changes in adipose tissue of pinealectomized rats. Horm Metab Res 2004 36 : 474 479.
49. Acuna D, Garcia del Rio C, Garcia-Torres L et al. Role of pineal gland in kidney-adrenal homeostasis. Horm Metab Res 1984 16 : 589 592.
50. Danforth WH. Glycogen synthetase activity in skeletal muscle: interconversion of two forms and control of glycogen synthesis. Biol Chem 1985 240 : 588 593.
51. Seraphim PM, Bartol I, Cipolla-Neto J et al. Quantification of GLUT4 transporter in insulin-sensitive tissue from pinealectomized rats. In : Pineal Update: From Molecular Mechanisms to Clinical Implications. Webb SM, Puig-Domingo M, Moller M, Pevet P, eds. PJD Publications Ltd, Westbury, 1997 pp. 99 107.
52. Ghosh G, DE K, Maity S et al. Melatonin protects against oxidative damage and restores expression of GLUT4 gene in the hyperthyroid rat heart. J Pineal Res 2007 42 : 71 82.
53. Susan A, Agius L. Leptin enhances glucogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin. Diabetes 1999 48 : 15 20.
54. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ et al. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 2001 280 : E827 E847.
55. Borges-Silva CN, Fonseca-Alaniz MH, Alonso-Vale MIC et al. Reduced lipolysis and increased lipogenesis in adipose tissue from pinealectomized rats adapted to training. J Pineal Res 2005 39 : 178 184.
56. Alonso-Vale MIC, Andreotti S, Peres SB et al. Melatonin enhances leptin expression by rat adipocytes in the presence of insulin. Am J Physiol Endocrinol Metab 2005 288 : 805 812.