Dedifferentiated chordoma of the thoracic spine with rhabdomyosarcomatous differentiation. Report of a case and review of the literature

Annals of Diagnostic Pathology

Volumn 11, Issue 4, 2007, Pages 262-273

  Bisceglia, Michele ^a   D'Angelo, Vincenzo Antonio ^a   Guglielmi, Giuseppe ^a   Dor, David Ben ^b   Pasquinelli, Gianandrea ^c  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b BARZILAI MEDICAL CENTER   (Israel)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Chordoma; Dedifferentiation; Physaliphorous cells; Rhabdomyosarcoma; Thoracic spine

Indexed keywords

AGED; ARTICLE; CANCER INVASION; CANCER PALLIATIVE THERAPY; CANCER SURGERY; CASE REPORT; CHORDOMA; DIAGNOSTIC ERROR; ELECTRON MICROSCOPY; FATALITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SPINAL CORD COMPRESSION; SPINE TUMOR; THORACIC SPINE; TUMOR BIOPSY; TUMOR DIAGNOSIS; TUMOR DIFFERENTIATION; VERTEBRA BODY; VERTEBRAL CANAL;

AGED; CHORDOMA; CYTOPLASM; FATAL OUTCOME; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NEOPLASMS, MULTIPLE PRIMARY; PALLIATIVE CARE; RHABDOMYOSARCOMA; SPINAL NEOPLASMS; SPINE; THORACIC VERTEBRAE; TUMOR MARKERS, BIOLOGICAL;

EID: 34447282477     PISSN: 10929134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anndiagpath.2006.09.002     Document Type: Article

References (94)

1. Huvos A.G. Bone tumors. Diagnosis, treatment, and prognosis. 2nd ed (1991), WB Saunders, Philadelphia (Pa) 599-624
2. Unni K.K. Dahlin's bone tumors: general aspects and data on 11,087 Cases. 5th ed. (1996), Lippincott-Raven, Philadelphia (Pa) 291-305
3. Dorfman H.D., and Czerniak B. Bone tumors (1998), Mosby, St Louis (Mo) 1139-1152
4. Campanacci M. Bone and soft tissues tumors. Bologna: Aulo Gaggi; Berlin: Springer-Verlag, 1990, p. 689-705.
5. Topsakal C., Bulut S., Erol F.S., et al. Chordoma of the thoracic spine-case report. Neurol Med Chir 42 (2002) 175-180
6. Heffelfinger M.J., Dahlin D.C., MacCarty C.S., et al. Chordomas and cartilaginous tumors at the skull base. Cancer 32 (1973) 410-420
7. Chambers P.W., and Schwinn C.P. Chordoma. A clinicopathologic study of metastasis. Am J Clin Pathol 72 (1979) 765-776
8. Volpe R., and Mazabraud A. A clinicopathologic review of 25 cases of chordoma (a pleomorphic and metastasizing neoplasm). Am J Surg Pathol 7 (1983) 161-170
9. Meis J.M., Raymond A.K., Evans H.L., et al. "Dedifferentiated" chordoma. A clinicopathologic and immunohistochemical study of three cases. Am J Surg Pathol 11 (1987) 516-525
10. Fox J.E., Batsakis J.G., and Owano L.R. Unusual manifestations of chordoma. A report of two cases. J Bone Joint Surg Am 50 (1968) 1618-1628
11. Nanda A., Hirsh L.F., and Antoiniades K. Malignant fibrous histiocytoma in a recurrent thoracic chordoma: case report and literature review. Neurosurgery 28 (1991) 588-592
12. Boriani S., Chevalley F., Weinstein J.N., et al. Chordoma of the spine above the sacrum. Treatment and outcome in 21 cases. Spine 21 (1996) 1569-1577
13. McMaster M.L., Goldstein A.M., Bromley C.M., et al. Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Causes Control 12 (2001) 1-11
14. Coffin C.M., Swanson P.E., Wick M.R., et al. Chordoma in childhood and adolescence. A clinicopathologic analysis of 12 cases. Arch Pathol Lab Med 117 (1993) 927-933
15. Utne J.R., and Pugh D.g. The roentgenologic aspects of chordoma. Am J Roentgenol Radium Ther Nucl Med 74 (1955) 593-608
16. Buraczewski J., and Rudowski W. Chordoma of the thoracic spine appearing as a mediastinal tumor; report of two cases. J Thorac Surg 34 (1957) 75-84
17. Caputo P.J. Chordoma of the thoracic spine; case report of a rare entity. Northwest Med 58 (1959) 553-554
18. Higinbotham N.L., Phillips R.F., Farr H.W., et al. Chordoma. Thirty-five-year study at Memorial Hospital. Cancer 20 (1967) 1841-1850
19. Gregorius F.K., and Batzdorf U. Removal of thoracic chordoma by staged laminectomy and thoracotomy: case report. Am Surg 45 (1979) 535-537
20. Sundaresan N., Galicich J.H., Chu F.C., et al. Spinal chordomas. J Neurosurg 50 (1979) 312-319
21. Stratt B., and Steiner R.M. The radiologic findings in posterior mediastinal chordoma. Skeletal Radiol 5 (1980) 171-173
22. Cotler H.B., Cotler J.M., Cohn H.E., et al. Intrathoracic chordoma presenting as a posterior superior mediastinal tumor. Spine 8 (1983) 781-786
23. Meyer J.E., Lepke R.A., Lindfors K.K., et al. Chordomas: their CT appearance in the cervical, thoracic and lumbar spine. Radiology 153 (1984) 693-696
24. Schwarz S.S., Fisher III W.S., and Pulliam M.W. Thoracic chordoma in a patient with paraparesis and ivory vertebral body. Neurosurgery 16 (1985) 100-102
25. Rich T.A., Schiller A., Suit H.D., et al. Clinical and pathologic review of 48 cases of chordoma. Cancer 56 (1985) 182-187
26. Bellotti C., Ettorre F., Oliveri G., et al. Dorsal vertebral chordoma with intrathoracic invasion. Surgical treatment of a case. Neurochirurgie 32 (1986) 86-89
27. Amendola B.E., Amendola M.A., Oliver E., et al. Chordoma: role of radiation therapy. Radiology 158 (1986) 839-843
28. Brooks M., Kleefield J., O'Reilly G.V., et al. Thoracic chordoma with unusual radiographic features. Comput Radiol 11 (1987) 85-90
29. Kaulbach C., Heller M., and Loning T. Thoracic chordoma. Rontgenblatter 43 (1990) 295-297
30. Winants D., Bertal A., Hennequin L., et al. Imaging of cervical and thoracic chordoma. Apropos of 2 cases. J Radiol 73 (1992) 169-174
31. Walsh T.M., and Mayer P.J. Chordoma of the thoracic spine presenting as a second primary malignant lesion. A case report. Spine 17 (1992) 1524-1528
32. Bjornsson J., Wold L.E., Ebersold M.J., et al. Chordoma of the mobile spine. A clinicopathologic analysis of 40 patients. Cancer 71 (1993) 735-740
33. Meador T., and Wivell W. Thoracic spine mass in a 34-year-old man. Acad Radiol 4 (1997) 157-158
34. Cury J.D., Peterson R.J., Lacy G.D., et al. Tracheal deviation from an atypical mediastinal mass. Chest 111 (1997) 503-505
35. Murphy J.M., Wallis F., Toland J., et al. CT and MRI appearances of a thoracic chordoma. Eur Radiol 8 (1998) 1677-1679
36. Bergh P., Kindblom L.G., Gunterberg B., et al. Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer 88 (2000) 2122-2134
37. Soyer J., Le Carrou T., Wager M., et al. Difficulty in treating spinal chordoma of the thoracic vertebrae. Neurochirurgie 47 (2001) 69-71
38. Crapanzano J.P., Ali S.Z., Ginsberg M.S., et al. Chordoma: a cytologic study with histologic and radiologic correlation. Cancer 93 (2001) 40-51
39. Husain F. Chordoma of the thoracic spine. Report of a case. J Bone Joint Surg Br 42-B (1960) 560-564
40. Ahrendt M.N., and Wesselhoeft C.W. Chordoma presenting as a posterior mediastinal mass in a pediatric patient. J Pediatr Surg 27 (1992) 1515-1518
41. Cesinaro A.M., Maiorana A., Collina G., et al. Extra-axial chordoma. Report of a case with immunohistochemical study. Pathologica 85 (1993) 755-760
42. Taki S., Kakuda K., Kakuma K., et al. Posterior mediastinal chordoma: MR imaging findings. AJR Am J Roentgenol 166 (1996) 26-27
43. Catalano O., Sandomenico F., and Nunziata A. Giant mediastinal chordoma. Description of a case. Radiol Med (Torino) 99 (2000) 390-391
44. Mahassini N., Bernoussi Z., Toubi F., et al. Chordoma: atypical mediastinal mass. Report of a case. Rev Pneumol Clin 57 (2001) 427-430
45. Huang S.M., Chen C.C., Chiu P.C., et al. Unusual presentation of posterior mediastinal chordoma in a 2-year-old boy. J Pediatr Hematol Oncol 25 (2003) 743-746
46. Suster S., and Moran C.A. Chordomas of the mediastinum: clinicopathologic, immunohistochemical, and ultrastructural study of six cases presenting as posterior mediastinal masses. Hum Pathol 26 (1995) 1354-1362
47. Roddie M., Adam A., Lambert H., et al. Case report 516: lumbar vertebral chordoma causing sclerosis of affected vertebra (3rd lumbar vertebra). Skeletal Radiol 17 (1989) 611-613
48. Erdem E., Angtuaco E.C., Van Hemert R., et al. Comprehensive review of intracranial chordoma. Radiographics 23 (2003) 995-1009
49. D'Haen B., De Jaegere T., Goffin J., et al. Chordoma of the lower cervical spine. Clin Neurol Neurosurg 97 (1995) 245-248
50. Ng W.K., and Tang V. Crush preparation findings of "sarcomatoid" chordoma of the sacrum: report of a case with histologic, immunohistochemical, and ultrastructural correlation. Diagn Cytopathol 25 (2001) 406-410
51. Fan F., Templeton K., and Damjanov I. Epithelioid cellular chordoma of the sacrum: a potential diagnostic problem. Ann Diagn Pathol 9 (2005) 139-412
52. Losi L., and Tomasich G. Dedifferentiated (sarcomatoid) chordoma in the base of the skull. Report of a case. Pathologica 88 (1996) 514-518
53. Morimitsu Y., Aoki T., Yokoyama K., et al. Sarcomatoid chordoma: chordoma with a massive malignant spindle-cell component. Skeletal Radiol 29 (2000) 721-725
54. Ghadially F.N. Diagnostic electron microscopy of tumours. 2nd ed. (1985), Butterworths, London 308-313
55. Erlandson R.A. Diagnostic transmission electron microscopy of tumors (1994), Raven Press, New York (NY) 324-327
56. Dickersin G.R. Diagnostic electron microscopy. A text/Atlas. 2nd ed. (2000), Springer-Verlag, New York (NY) 604-612
57. Wojno K.J., Hruban R.H., Garin-Chesa P., et al. Chondroid chordomas and low-grade chondrosarcomas of the craniospinal axis. An immunohistochemical analysis of 17 cases. Am J Surg Pathol 16 (1992) 1144-1152
58. Dahlin D.C., and Beabout J.W. Dedifferentiation of low-grade chondrosarcomas. Cancer 28 2 (1971) 461-466
59. McCarthy E.F., and Dorfman H.D. Chondrosarcoma of bone with dedifferentiation: a study of eighteen cases. Hum Pathol 13 (1982) 36-40
60. Debernardi L. Cordoma sarcomatoso del sacro-contributo alla conoscenza istologica e clinica dei tumori di origine cordale. Arch Sci Med (Torino) 37 (1913) 454-456
61. Davison C., and Weil A. Malignant chordoma of the lumbar region. Arch Neurol Psychyatry 19 (1928) 415-423
62. Mabrey R.E. Chordoma. A study of 150 cases. Am J Cancer 25 (1935) 501-517
63. Poppen J.L., and King A.B. Chordoma: experience with thirteen cases. J Neurosurg 9 (1952) 139-163
64. Knechtges T.C. Sacrococcygeal chordoma with sarcomatous features (spindle cell metaplasia). Am J Clin Pathol 53 (1970) 612-616
65. Makek M., and Leu H.J. Malignant fibrous histiocytoma arising in a recurrent chordoma. Case report and electron microscopic findings. Virchows Arch A Pathol Anat Histol 397 (1982) 241-250
66. Miettinen M., Lehto V.P., and Virtanen I. Malignant fibrous histiocytoma within a recurrent chordoma. A light microscopic, electron microscopic, and immunohistochemical study. Am J Clin Pathol 82 (1984) 738-743
67. Halpern J., Kopolovic J., and Catane R. Malignant fibrous histiocytoma developing in irradiated sacral chordoma. Cancer 53 (1984) 2661-2662
68. Kishikawa H., and Tanaka K. Chordoma-report of an autopsy case with fibrosarcoma. Acta Pathol Jpn 24 (1974) 299-308
69. Belza M.G., and Urich H. Chordoma and malignant fibrous histiocytoma. Evidence for transformation. Cancer 58 (1986) 1082-1087
70. Rone R., Ramzy I., and Duncan D. Anaplastic sacrococcygeal chordoma. Fine needle aspiration cytologic findings and embryologic considerations. Acta Cytol 30 (1986) 183-188
71. Miettinen M., Karaharju E., and Jarvinen H. Chordoma with a massive spindle-cell sarcomatous transformation. A light- and electron-microscopic and immunohistological study. Am J Surg Pathol 11 (1987) 563-570
72. Smith J., Reuter V., and Demas B. Case report 576. Anaplastic sacrococcygeal chordoma (dedifferentiated chordoma). Skeletal Radiol 18 (1989) 561-564
73. Hruban R.H., May M., Marcove R.C., et al. Lumbo-sacral chordoma with high-grade malignant cartilaginous and spindle cell components. Am J Surg Pathol 14 (1990) 384-389
74. Tomlinson F.H., Scheithauer B.W., Forsythe P.A., et al. Sarcomatous transformation in cranial chordoma. Neurosurgery 31 (1992) 13-18
75. Fukuda T., Aihara T., Ban S., et al. Sacrococcygeal chordoma with a malignant spindle cell component. A report of two autopsy cases with a review of the literature. Acta Pathol Jpn 42 (1992) 448-453
76. Fleming G.F., Heimann P.S., Stephens J.K., et al. Dedifferentiated chordoma. Response to aggressive chemotherapy in two cases. Cancer 72 (1993) 714-718
77. Choi Y.J., and Kim T.S. Malignant fibrous histiocytoma in chordoma-immunohistochemical evidence of transformation from chordoma to malignant fibrous histiocytoma. Yonsei Med J 35 (1994) 239-243
78. Ikeda H., Honjo J., Sakurai H., et al. Dedifferentiated chordoma arising in irradiated sacral chordoma. Radiat Med 15 (1997) 109-111
79. Woenckhaus J., Benedix P., Holotiuk O., et al. Sacrococcygeal chordoma with malignant spindle cell components. Case report and review of the literature. Pathologe 18 (1997) 395-400
80. Saito A., Hasegawa T., Shimoda T., et al. Dedifferentiated chordoma: a case report. Jpn J Clin Oncol 28 (1998) 766-771
81. Layfield L.J., Liu K., Dodd L.G., et al. "Dedifferentiated" chordoma: a case report of the cytomorphologic findings on fine-needle aspiration. Diagn Cytopathol 19 (1998) 378-381
82. Munshi H.G., Merajver S.D., Valdez R., et al. Metastatic dedifferentiated chordoma with elevated beta-hCG: a case report. Am J Clin Oncol 25 (2002) 274-276
83. Sahasrabudhe N.S., Jadhav M.V., and Holla V.V. Dedifferentiated chordoma-a case report. Indian J Pathol Microbiol 45 (2002) 353-354
84. Sefiani S., Amarti A., Maher M., et al. Dedifferentiated chordoma of the skull base. A case report. Neurochirurgie 48 (2002) 436-439
85. Gil Z., Fliss D.M., Voskoboinik N., et al. Cytogenetic analysis of three variants of clival chordoma. Cancer Genet Cytogenet 154 (2004) 124-130
86. Rosenberg A.E., Brown G.A., Bhan A.K., et al. Chondroid chordoma-a variant of chordoma. A morphologic and immunohistochemical study. Am J Clin Pathol 101 (1994) 36-41
87. Brooks J.J., LiVolsi V.A., and Trojanowski J.Q. Does chondroid chordoma exist?. Acta Neuropathol (Berl) 72 (1987) 229-235
88. Walker W.P., Landas S.K., Bromley C.M., et al. Immunohistochemical distinction of classic and chondroid chordomas. Mod Pathol 4 (1991) 661-666
89. Rutherfoord G.S., and Davies A.G. Chordomas-ultrastructure and immunohistochemistry: a report based on the examination of six cases. Histopathology (1987) 775-787
90. Meis J.M., and Giraldo A.A. Chordoma. An immunohistochemical study of 20 cases. Arch Pathol Lab Med 112 (1988) 553-556
91. Brooks J.J., Trojanowski J.Q., and LiVolsi V.A. Chondroid chordoma: a low-grade chondrosarcoma and its differential diagnosis. Curr Top Pathol 80 (1989) 165-181
92. Reith J.D., Bauer T.W., Fischler D.F., et al. Dedifferentiated chondrosarcoma with rhabdomyosarcomatous differentiation. Am J Surg Pathol 20 (1996) 293-298
93. Shanks J.H., Banerjee S.S., and Eyden B.P. Focal rhabdomyosarcomatous differentiation in primary liposarcoma. J Clin Pathol 49 (1996) 770-772
94. Eusebi V., Damiani S., Pasquinelli G., et al. Small cell neuroendocrine carcinoma with skeletal muscle differentiation: report of three cases. Am J Surg Pathol 24 (2000) 223-230