메뉴 건너뛰기




Volumn 259, Issue 1-2, 2007, Pages 74-78

Immunosuppression: Promises and failures

Author keywords

Azathioprine; Clinical trials; Corticosteroids; Cyclophosphamide; Immunosuppression; Metotrexate; Mitoxantrone; Multiple sclerosis

Indexed keywords

ALEMTUZUMAB; AZATHIOPRINE; BETA INTERFERON; CLADRIBINE; CORTICOSTEROID; CORTICOTROPIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FINGOLIMOD; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INTERFERON; INTERFERON BETA SERINE; METHOTREXATE; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; MITOXANTRONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NATALIZUMAB; PACLITAXEL; PREDNISONE; STEROID;

EID: 34447279095     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2006.05.073     Document Type: Article
Times cited : (11)

References (38)
  • 1
    • 0023194967 scopus 로고
    • A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 1. Clinical effects
    • Milligan N.M., Newcombe R., and Compston D.A. A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 1. Clinical effects. Neurol Neurosurg Psychiatry 50 5 (1987) 511-516
    • (1987) Neurol Neurosurg Psychiatry , vol.50 , Issue.5 , pp. 511-516
    • Milligan, N.M.1    Newcombe, R.2    Compston, D.A.3
  • 3
    • 0030995211 scopus 로고    scopus 로고
    • Randomised trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosis
    • Barnes D., Hughes R.A., Morris R.W., Wade-Jones O., Brown P., Britton T., et al. Randomised trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosis. Lancet 349 9056 (1997) 902-906
    • (1997) Lancet , vol.349 , Issue.9056 , pp. 902-906
    • Barnes, D.1    Hughes, R.A.2    Morris, R.W.3    Wade-Jones, O.4    Brown, P.5    Britton, T.6
  • 4
    • 0027515341 scopus 로고
    • The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group
    • Beck R.W., Cleary P.A., Trobe J.D., Kaufman D.I., Kupersmith M.J., Paty D.W., et al. The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group. N Engl J Med 329 24 (1993) 1764-1769
    • (1993) N Engl J Med , vol.329 , Issue.24 , pp. 1764-1769
    • Beck, R.W.1    Cleary, P.A.2    Trobe, J.D.3    Kaufman, D.I.4    Kupersmith, M.J.5    Paty, D.W.6
  • 5
    • 0010617014 scopus 로고
    • Treatment of multiple sclerosis with high-dose methylprednisolone pulse therapy
    • Whitham R.H., and Bourdette D.N. Treatment of multiple sclerosis with high-dose methylprednisolone pulse therapy. Neurology 39 1 (1989) 357
    • (1989) Neurology , vol.39 , Issue.1 , pp. 357
    • Whitham, R.H.1    Bourdette, D.N.2
  • 7
    • 0014007245 scopus 로고
    • Multiple sclerosis and the autoimmunization process. Treatment by antimitotics
    • Aimard G., Girard P.F., and Raveau J. Multiple sclerosis and the autoimmunization process. Treatment by antimitotics. Lyon Med 2156 6 (1966) 345-352
    • (1966) Lyon Med , vol.2156 , Issue.6 , pp. 345-352
    • Aimard, G.1    Girard, P.F.2    Raveau, J.3
  • 8
    • 0015928042 scopus 로고
    • Are there any changes in CSF IgG levels in multiple sclerosis treated for long periods with an immunosuppressive agent (azathioprine)
    • Oger J., Cloarec L., Chatel M., and Sabouraud O. Are there any changes in CSF IgG levels in multiple sclerosis treated for long periods with an immunosuppressive agent (azathioprine). Nouv Presse Med 2 7 (1973) 443
    • (1973) Nouv Presse Med , vol.2 , Issue.7 , pp. 443
    • Oger, J.1    Cloarec, L.2    Chatel, M.3    Sabouraud, O.4
  • 9
    • 0023905890 scopus 로고
    • Double blind controlled randomized study on azathioprine efficacy in multiple sclerosis, preliminary results
    • Milanese C., La Mantia L., Salmaggi A., Campi A., Bortolami C., Tajoli L., et al. Double blind controlled randomized study on azathioprine efficacy in multiple sclerosis, preliminary results. Ital J Neurol Sci 9 (1988) 53-57
    • (1988) Ital J Neurol Sci , vol.9 , pp. 53-57
    • Milanese, C.1    La Mantia, L.2    Salmaggi, A.3    Campi, A.4    Bortolami, C.5    Tajoli, L.6
  • 10
    • 0024462396 scopus 로고
    • A placebo-controlled, randomized, double-masked, variable dosage clinical trial of azathioprine with and without methylprednisolone in multiple sclerosis
    • Ellison G.W., Myers L.W., and Mickey M.R. A placebo-controlled, randomized, double-masked, variable dosage clinical trial of azathioprine with and without methylprednisolone in multiple sclerosis. Neurology 39 8 (1989) 1018-1026
    • (1989) Neurology , vol.39 , Issue.8 , pp. 1018-1026
    • Ellison, G.W.1    Myers, L.W.2    Mickey, M.R.3
  • 11
    • 68949125991 scopus 로고
    • Double-masked trial of azathioprine in multiple sclerosis
    • British and Dutch Multiple Sclerosis Azathioprine Trial Group
    • British and Dutch Multiple Sclerosis Azathioprine Trial Group. Double-masked trial of azathioprine in multiple sclerosis. Lancet 2 (1988) 179-183
    • (1988) Lancet , vol.2 , pp. 179-183
  • 12
    • 0021314441 scopus 로고
    • Long-term immunosuppression in multiple sclerosis: evaluation of treatments begun before 1972
    • Sabouraud O., Oger J., Darcel F., Madigand M., and Merienne M. Long-term immunosuppression in multiple sclerosis: evaluation of treatments begun before 1972. Rev Neurol (Paris) 140 2 (1984) 125-130
    • (1984) Rev Neurol (Paris) , vol.140 , Issue.2 , pp. 125-130
    • Sabouraud, O.1    Oger, J.2    Darcel, F.3    Madigand, M.4    Merienne, M.5
  • 13
    • 0036200216 scopus 로고    scopus 로고
    • Results of an international questionnaire on immunosuppressive treatment of multiple sclerosis
    • Hommes O., and Weiner H. Results of an international questionnaire on immunosuppressive treatment of multiple sclerosis. Mult Scler 8 (2002) 139-141
    • (2002) Mult Scler , vol.8 , pp. 139-141
    • Hommes, O.1    Weiner, H.2
  • 14
    • 3142630125 scopus 로고    scopus 로고
    • Clinical practice of immunosuppressive treatments in multiple sclerosis: results of a second international questionnaire
    • Hommes O., and Weiner H. Clinical practice of immunosuppressive treatments in multiple sclerosis: results of a second international questionnaire. J Neurol Sci 223 (2004) 65-67
    • (2004) J Neurol Sci , vol.223 , pp. 65-67
    • Hommes, O.1    Weiner, H.2
  • 15
    • 34447266478 scopus 로고    scopus 로고
    • Sabouraud, O. and Oger, J. personal communication 1974.
  • 16
    • 15544375688 scopus 로고    scopus 로고
    • Optimization of the safety and efficacy of interferon beta 1b and azathioprine combination therapy in multiple sclerosis
    • Pulicken M., Bash C.N., Costello K., Said A., Cuffari C., Wilterdink J.L., et al. Optimization of the safety and efficacy of interferon beta 1b and azathioprine combination therapy in multiple sclerosis. Mult Scler 11 2 (2005) 169-174
    • (2005) Mult Scler , vol.11 , Issue.2 , pp. 169-174
    • Pulicken, M.1    Bash, C.N.2    Costello, K.3    Said, A.4    Cuffari, C.5    Wilterdink, J.L.6
  • 17
    • 0023707296 scopus 로고
    • Cyclosporine versus azathioprine in the long-term treatment of multiple sclerosis - results of the German multicenter study
    • Kappos L., Patzold U., Dommasch D., Poser S., Haas J., Krauseneck P., et al. Cyclosporine versus azathioprine in the long-term treatment of multiple sclerosis - results of the German multicenter study. Ann Neurol 23 1 (1988) 56-63
    • (1988) Ann Neurol , vol.23 , Issue.1 , pp. 56-63
    • Kappos, L.1    Patzold, U.2    Dommasch, D.3    Poser, S.4    Haas, J.5    Krauseneck, P.6
  • 18
    • 0025345601 scopus 로고    scopus 로고
    • The Multiple Sclerosis Study Group. Efficacy of cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. Ann Neurol 27 (190) 591-605.
  • 19
    • 34447254782 scopus 로고
    • Immunosuppression with cyclophosphamide (Endoxan) in multiple sclerosis
    • Hommes O.R., Mertin J., and Tourtellotte W.W. (Eds), Stuart Phillips Publications, Sutton
    • Gonsette R.E., and Demnty L. Immunosuppression with cyclophosphamide (Endoxan) in multiple sclerosis. In: Hommes O.R., Mertin J., and Tourtellotte W.W. (Eds). Immunotherapies in multiple sclerosis (1986), Stuart Phillips Publications, Sutton 139-150
    • (1986) Immunotherapies in multiple sclerosis , pp. 139-150
    • Gonsette, R.E.1    Demnty, L.2
  • 20
    • 0016756307 scopus 로고
    • Cyclophosphamide in exacerbations of multiple sclerosis. Therapeutic trial and a strategy for pilot drug studies
    • Drachman D.A., Paterson P.Y., Schmidt R.T., and Spehlmann R.F. Cyclophosphamide in exacerbations of multiple sclerosis. Therapeutic trial and a strategy for pilot drug studies. J Neurol Neurosurg Psychiatry 38 (1975) 592-597
    • (1975) J Neurol Neurosurg Psychiatry , vol.38 , pp. 592-597
    • Drachman, D.A.1    Paterson, P.Y.2    Schmidt, R.T.3    Spehlmann, R.F.4
  • 21
    • 0020683886 scopus 로고
    • Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange and ACTH
    • Hauser S.L., Dawson D.M., Lehrich J.R., Beal M.F., Kevy S.V., Propper R.D., et al. Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange and ACTH. N Engl J Med 308 (1983) 173-180
    • (1983) N Engl J Med , vol.308 , pp. 173-180
    • Hauser, S.L.1    Dawson, D.M.2    Lehrich, J.R.3    Beal, M.F.4    Kevy, S.V.5    Propper, R.D.6
  • 23
    • 0026317943 scopus 로고
    • Intense immunosuppression in chronic progressive multiple sclerosis: the Kaiser study
    • Likosky W.H., Fireman B., Elmore R., Eno G., Gale K., Goode G.B., et al. Intense immunosuppression in chronic progressive multiple sclerosis: the Kaiser study. J Neurol Neurosurg Psychiatry 54 12 (1991) 1055-1060
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , Issue.12 , pp. 1055-1060
    • Likosky, W.H.1    Fireman, B.2    Elmore, R.3    Eno, G.4    Gale, K.5    Goode, G.B.6
  • 24
    • 0025967752 scopus 로고
    • The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. The Canadian Cooperative Multiple Sclerosis Study Group
    • Canadian Cooperative study. The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. The Canadian Cooperative Multiple Sclerosis Study Group. Lancet 337 8739 (1991) 441-446
    • (1991) Lancet , vol.337 , Issue.8739 , pp. 441-446
    • Canadian Cooperative study1
  • 25
    • 25844530825 scopus 로고    scopus 로고
    • A randomized blinded trial of combination therapy with cyclophosphamide in patients with active multiple sclerosis on interferon beta
    • Smith D.R., Weinstock-Guttman B., Cohen J.A., Wei X., Gutmann C., Bakshi R., et al. A randomized blinded trial of combination therapy with cyclophosphamide in patients with active multiple sclerosis on interferon beta. Mult Scler 11 5 (2005) 573-582
    • (2005) Mult Scler , vol.11 , Issue.5 , pp. 573-582
    • Smith, D.R.1    Weinstock-Guttman, B.2    Cohen, J.A.3    Wei, X.4    Gutmann, C.5    Bakshi, R.6
  • 26
    • 12844251832 scopus 로고    scopus 로고
    • Stabilization of rapidly worsening multiple sclerosis for 36 months in patients treated with interferon beta plus cyclophosphamide followed by interferon beta
    • Patti F., Reggio E., Palermo F., Fiorilla T., Politi G., Nicoletti A., et al. Stabilization of rapidly worsening multiple sclerosis for 36 months in patients treated with interferon beta plus cyclophosphamide followed by interferon beta. J Neurol 251 12 (2004) 1502-1506
    • (2004) J Neurol , vol.251 , Issue.12 , pp. 1502-1506
    • Patti, F.1    Reggio, E.2    Palermo, F.3    Fiorilla, T.4    Politi, G.5    Nicoletti, A.6
  • 27
    • 26444598492 scopus 로고    scopus 로고
    • Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis
    • Stuve O., Cepok S., Elias B., Saleh A., Hartung H.P., Hemmer B., et al. Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis. Arch Neurol 62 10 (2005) 1620-1623
    • (2005) Arch Neurol , vol.62 , Issue.10 , pp. 1620-1623
    • Stuve, O.1    Cepok, S.2    Elias, B.3    Saleh, A.4    Hartung, H.P.5    Hemmer, B.6
  • 28
    • 0027225747 scopus 로고
    • An open-trial evaluation of mitoxantrone in the treatment of progressive MS
    • Noseworthy J.H., Hopkins M.B., Vandervoort M.K., et al. An open-trial evaluation of mitoxantrone in the treatment of progressive MS. Neurology 43 7 (1993) 1401-1406
    • (1993) Neurology , vol.43 , Issue.7 , pp. 1401-1406
    • Noseworthy, J.H.1    Hopkins, M.B.2    Vandervoort, M.K.3
  • 29
  • 30
    • 0031040238 scopus 로고    scopus 로고
    • Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomized multicentre study of active disease using MRI and clinical criteria
    • Edan G., Miller D., Clanet M., Confavreux C., Lyon-Caen O., Lubetzki C., et al. Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomized multicentre study of active disease using MRI and clinical criteria. J Neurol Neurosurg Psychiatry 62 2 (1997) 112-118
    • (1997) J Neurol Neurosurg Psychiatry , vol.62 , Issue.2 , pp. 112-118
    • Edan, G.1    Miller, D.2    Clanet, M.3    Confavreux, C.4    Lyon-Caen, O.5    Lubetzki, C.6
  • 31
    • 8044242916 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome
    • Millefiorini E., Gasperini C., Pozzilli C., D'Andrea F., Bastianello S., Trojano M., et al. Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome. J Neurol 244 3 (1997) 153-159
    • (1997) J Neurol , vol.244 , Issue.3 , pp. 153-159
    • Millefiorini, E.1    Gasperini, C.2    Pozzilli, C.3    D'Andrea, F.4    Bastianello, S.5    Trojano, M.6
  • 32
    • 0037153729 scopus 로고    scopus 로고
    • Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomized, multicentre trial
    • Hartung H.P., Gonsette R., Konig N., Kwiecinski H., Guseo A., Morrissey S.P., et al. Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomized, multicentre trial. Lancet 360 9350 (2002) 2018-2025
    • (2002) Lancet , vol.360 , Issue.9350 , pp. 2018-2025
    • Hartung, H.P.1    Gonsette, R.2    Konig, N.3    Kwiecinski, H.4    Guseo, A.5    Morrissey, S.P.6
  • 33
    • 0345305703 scopus 로고    scopus 로고
    • The use of mitoxantrone (Novantrone) for the treatment of multiple sclerosis
    • Goodin D.S., Arnason B.G., Coyle P.K., Frohman E.M., and Paty D.W. The use of mitoxantrone (Novantrone) for the treatment of multiple sclerosis. Neurology 61 (2003) 1332-1338
    • (2003) Neurology , vol.61 , pp. 1332-1338
    • Goodin, D.S.1    Arnason, B.G.2    Coyle, P.K.3    Frohman, E.M.4    Paty, D.W.5
  • 34
    • 8044242916 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24 month clinical and MRI outcome
    • Millefiorini E., Gasperini C., Pozzilli C., D'Andrea F., Bastianello S., Trojano M., et al. Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24 month clinical and MRI outcome. J Neurol 244 (1997) 153-159
    • (1997) J Neurol , vol.244 , pp. 153-159
    • Millefiorini, E.1    Gasperini, C.2    Pozzilli, C.3    D'Andrea, F.4    Bastianello, S.5    Trojano, M.6
  • 36
    • 0002773071 scopus 로고    scopus 로고
    • Safety profile of mitoxantrone in a cohort of 802 multiple sclerosis patients
    • Edan G., Brassat D., and Clanet M. Safety profile of mitoxantrone in a cohort of 802 multiple sclerosis patients. Neurology 58 3 (2002) A168
    • (2002) Neurology , vol.58 , Issue.3
    • Edan, G.1    Brassat, D.2    Clanet, M.3
  • 37
    • 0037167538 scopus 로고    scopus 로고
    • Cardiac adverse effects associated with mitoxantrone (Novantrone) therapy in patients with MS
    • Ghalie R.G., Edan G., Laurent M., Mauch E., Eisenman S., Hartung H.P., et al. Cardiac adverse effects associated with mitoxantrone (Novantrone) therapy in patients with MS. Neurology 59 (2002) 909-913
    • (2002) Neurology , vol.59 , pp. 909-913
    • Ghalie, R.G.1    Edan, G.2    Laurent, M.3    Mauch, E.4    Eisenman, S.5    Hartung, H.P.6
  • 38
    • 34447269746 scopus 로고    scopus 로고
    • http://www.clinicaltrials.gov/ct/search.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.