Advances in malaria diagnosis

Expert Review of Anti-Infective Therapy

Volumn 5, Issue 3, 2007, Pages 485-495

  Hawkes, Michael ^a   Kain, Kevin C ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Flow cytometry; Malaria; Mass spectrometry; PCR; Plasmodium; Rapid diagnostic tests

Indexed keywords

ACRIDINE ORANGE; ANTIMALARIAL AGENT; DNA; FLUORESCENT DYE; FRUCTOSE BISPHOSPHATE ALDOLASE; HEMOZOIN; LACTATE DEHYDROGENASE; PARASITE ANTIGEN; RNA 18S; BIOLOGICAL MARKER; PROTOZOAL DNA;

AFRICA SOUTH OF THE SAHARA; AMINO ACID SEQUENCE; ANTIGEN DETECTION; BLOOD CELL COUNT; BLOOD CULTURE; CHROMATOGRAPHY; COST EFFECTIVENESS ANALYSIS; DEATH; DEVELOPED COUNTRY; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST; DNA HYBRIDIZATION; ENDEMIC DISEASE; ENZYME ASSAY; FLOW CYTOMETRY; GIEMSA STAIN; HEALTH CARE COST; HIGH THROUGHPUT SCREENING; HUMAN; INCIDENCE; MALARIA; MASS SPECTROMETRY; MICROARRAY ANALYSIS; MICROSCOPY; MONOCYTE; MORTALITY; OLIGONUCLEOTIDE PROBE; PATHOGENESIS; PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM VIVAX; POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; SENSITIVITY AND SPECIFICITY; SPECIES IDENTIFICATION; TRAVEL; ANIMAL; BLOOD; CLASSIFICATION; DNA MICROARRAY; GENETICS; IMMUNOASSAY; ISOLATION AND PURIFICATION; PLASMODIUM;

ANIMALS; BIOLOGICAL MARKERS; DNA, PROTOZOAN; FLOW CYTOMETRY; HUMANS; IMMUNOASSAY; MALARIA; MASS SPECTROMETRY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASMODIUM; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

EID: 34447265742     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.5.3.485     Document Type: Review

References (118)

1. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434(7030), 214-217 (2005).
2. Yamey G. Roll back malaria: a failing global health campaign. Br. Med. J. 328(7448), 1086-1087 (2004).
3. Nabarro DN, Tayler EM. The "roll back malaria" campaign. Science 280(5372), 2067-2068 (1998).
4. Kain KC, Harrington MA, Tennyson S, Keystone JS. Imported malaria: prospective analysis of problems in diagnosis and management. Clin. Infict. Dis. 27(1), 142-149 (1998).
5. Ryan ET, Wilson ME, Kain KC. Illness after international travel. N. Engl. J. Med. 347(7), 505-516 (2002).
6. Rafael ME, Taylor T, Magill A, Lim YW, Girosi F, Allan R. Reducing the burden of childhood malaria in Africa: the role of improved. Nature 444(Suppl. 1), 39-48 (2006).
7. Amexo M, Tolhurst R, Barnish G, Bates I. Malaria misdiagnosis: effects on the poor and vulnerable. Lancet 364(9448), 1896-1898 (2004).
8. Ohrt C, Purnomo, Sutamihardja MA, Tang D, Kain KC. Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials. J. Infect. Dis. 186(4), 540-546 (2002).
9. Perkins BA, Zucker JR, Otieno J et al. Evaluation of an algorithm for integrated management of childhood illness in an area of Kenya with high malaria transmission. Bull. World Health Organ. 75(Suppl. 1), 33-42 (1997).
10. Weber MW, Mulholland EK, Jaffar S, Troedsson H, Gove S, Greenwood BM. Evaluation of an algorithm for the integrated management of childhood illness in an area with seasonal malaria in the Gambia. Bull. World Health Organ. 75(Suppl. 1), 25-32 (1997).
11. Tarimo DS, Minjas JN, Bygbjerg IC. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal. Ann. Trop. Med. Parasitol. 95(5), 437-444 (2001).
12. Moody A. Rapid diagnostic tests for malaria parasites. Clin. Microbiol. Rev. 15(1), 66-78 (2002).
13. Ochola LB, Vounatsou P, Smith T, Mabaso ML, Newton CR. The reliability of diagnostic techniques in the diagnosis and management of malaria in the absence of a gold standard. Lancet Infect. Dis. 6(9), 582-588 (2006).
14. Jamjoom GA. Improvement in dark-field microscopy for the rapid detection of malaria parasites and its adaptation to field conditions. Trans. R. Soc. Trop. Med. Hyg. 85(1), 38-39 (1991).
15. Jamjoom GA. Dark-field microscopy for detection of malaria in unstained blood films. J. Clin. Microbiol. 17(5), 717-721 (1983).
16. Romagosa C, Menendez C, Ismail MR et al. Polarisation microscopy increases the sensitivity of hemozoin and Plasmodium detection in the histological assessment of placental malaria. Acta Trop. 90(3), 277-284 (2004).
17. Mendiratta DK, Bhutada K, Narang R, Narang P. Evaluation of different methods for diagnosis of P. falciparum malaria. Indian J. Med. Microbiol. 24(1), 49-51 (2006).
18. WHO. A rapid dipstick antigen capture assay for the diagnosis of falciparum malaria. WHO informal consultation on recent advances in diagnostic techniques and vaccines for malaria. Bull. World Health Organ. 74(1), 47-54 (1996).
19. Bell D, Wongsrichanalai C, Barnwell JW. Ensuring quality and access for malaria diagnosis: how can it be achieved? Nat. Rev. Microbiol. 4(9 Suppl.), S7-S20 (2006).
20. Marx A, Pewsner D, Egger M et al. Metaanalysis: accuracy of rapid tests for malaria in travelers returning from endemic areas. Ann. Intern. Med. 142(10), 836-846 (2005).
21. Pieroni P, Mills CD, Ohrt C, Harrington MA, Kain KC. Comparison of the ParaSight-F test and the ICT Malaria Pf test with the polymerase chain reaction for the diagnosis of Plasmodium falciparum malaria in travellers. Trans. R. Soc. Trop. Med. Hyg. 92(2), 166-169 (1998).
22. Jelinek T, Grobusch MP, Nothdurft HD. Use of dipstick tests for the rapid diagnosis of malaria in nonimmune travelers. J. Travel Med. 7(4), 175-179 (2000).
23. Chiodini PL, Bowers K, Jorgensen P et al. The heat stability of Plasmodium lactate dehydrogenase-based and histidine-rich protein 2-based malaria rapid diagnostic tests. Trans. R. Soc. Trop. Med. Hyg. 101(4), 331-337 (2007).
24. Jorgensen P, Chanthap, L, Rebueno A, Tsuyuoka R, Bell D. Malaria rapid diagnostic tests in tropical climates: the need for a cool chain. Am. J. Trop. Med. Hyg. 74(5), 750-754 (2006).
25. Rolland E, Checchi F, Pinoges L, Balkan S, Guthmann JP, Guerin PJ. Operational response to malaria epidemics: are rapid diagnostic tests cost-effective? Trop. Med. Int. Health 11(4), 398-408 (2006).
26. Waters AP, McCutchan TF. Rapid, sensitive diagnosis of malaria based on ribosomal RNA. Lancet 1(8651), 1343-1346 (1989).
27. Barker RH Jr, Suebsaeng L, Rooney W, Alecrim GC, Dourado HV, Wirth DF. Specific DNA probe for the diagnosis of Plasmodium falciparum malaria. Science 231(4744), 1434-1436 (1986).
28. Holmberg M, Vaidya AB, Shenton FC et al. A comparison of two DNA probes, one specific for Plasmodium falciparum and one with wider reactivity, in the diagnosis of malaria. Trans. R. Soc. Trop. Med. Hyg. 84(2), 202-205 (1990).
29. Schindler HC, Montenegro L, Montenegro R, Carvalho AB, Abath FG, Jaureguiberry G. Development and optimization of polymerase chain reaction-based malaria diagnostic methods and their comparison with quantitative buffy coat assay. Am J. Trop. Med. Hyg. 65(4), 355-361 (2001).
30. Sethabutr O, Brown AE, Gingrich J et al. A comparative field study of radiolabeled and enzyme-conjugated synthetic DNA probes for the diagnosis of falciparum malaria. Am. J. Trop. Med. Hyg. 39(3), 227-231 (1988).
31. Lanar DE, McLaughlin GL, Wirth DF, Barker RJ, Zolg JW, Chulay JD. Comparison of thick films, in vitro culture and DNA hybridization probes for detecting Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg. 40(1), 3-6 (1989).
32. Barker RH Jr. DNA probe diagnosis of parasitic infections. Exp. Parasitol. 70(4), 494-499 (1990).
33. Barker RH Jr, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF. A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction. Am. J. Trop. Med. Hyg. 46(4), 416-426 (1992).
34. Oliveira DA, Shi YP, Oloo AJ et al. Field evaluation of a polymerase chain reaction-based nonisotopic liquid hybridization assay for malaria diagnosis. J. Infect. Dis. 173(5), 1284-1287 (1996).
35. Snounou G, Viriyakosol S, Jarra W, Thaithong S, Brown KN. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections. Mol. Biochem. Parasitol. 58(2), 283-292 (1993).
36. Snounou G, Viriyakosol S, Zhu XP et al. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol. Biochem. Parasitol. 61(2), 315-320 (1993).
37. Li J, Wirtz RA, McConkey GA et al. Plasmodium: genus-conserved primers for species identification and quantitation. Exp. Parasitol. 81(2), 182-190 (1995).
38. McCutchan TF, de la Cruz VF, Lal AA, Gunderson JH, Elwood HJ, Sogin ML. Primary sequences of two small subunit ribosomal RNA genes from Plasmodium falciparum. Mol. Biochem. Parasitol. 28(1), 63-68 (1988).
39. Humar A, Harrington MA, Kain KC. Evaluation of a non-isotopic polymerase chain reaction-based assay to detect and predict treatment failure of Plasmodium vivax malaria in travellers. Trans. R. Soc. Trop. Med. Hyg. 91(4), 406-409 (1997).
40. Kimura M, Miyake H, Kim HS et al. Species-specific PCR detection of malaria parasites by microtiter plate hybridization: clinical study with malaria patients. J. Clin. Microbiol. 33(9), 2342-2346 (1995).
41. Zhong KJ, Kain KC. Evaluation of a colorimetric PCR-based assay to diagnose Plasmodium falciparum malaria in travelers. J. Clin. Microbiol. 37(2), 339-341 (1999).
42. Farcas GA, Zhong KJ, Mazzulli T, Kain KC. Evaluation ofthe RealArt Malaria LC real-time PCR assay for malaria diagnosis. J. Clin. Microbiol. 42(2), 636-638 (2004).
43. Vo TK, Bigot P, Gazin P et al. Evaluation of a real-time PCR assay for malaria diagnosis in patients from Vietnam and in returned travellers. Trans. R. Soc. Trop. Med. Hyg. 101(5), 422-428 (2007).
44. Perandin F, Manca N, Calderaro A et al. Development of a real-time PCR assay for detection of Plasmodium falciparum, Plasmodium vivax, and Plasmodium ovale for routine clinical diagnosis. J. Clin. Microbiol. 42(3), 1214-1219 (2004).
45. Mens PF, Schoone GJ, Kager PA, Schallig HD. Detection and identification of human Plasmodium species with real-time quantitative nucleic acid sequence-based amplification. Malar. J. 5, 80 (2006).
46. Swan H, Sloan L, Muyombwe A et al. Evaluation of a real-time polymerase chain reaction assay for the diagnosis of malaria in patients from Thailand. Am. J. Trop. Med. Hyg. 73(5), 850-854 (2005).
47. Farcas GA, Soeller R, Zhong K, Zahirieh A, Kain KC. Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers. Clin. Infect. Dis. 42(5), 622-627 (2006).
48. Basco LK, Tahar R, Keundjian A. Ringwald P. Sequence variations in the genes encoding dihydropteroate synthase and dihydrofolate reductase and clinical response to sulfadoxine-pyrimethamine in patients with acute uncomplicated falciparum malaria. J. Infect. Dis. 182(2), 624-628 (2000).
49. Schwobel B, Alifrangis M, Salanti A, Jelinek T. Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker. Malar. J. 2, 5 (2003).
50. Palacios G, Quan PL, Jabado QJ et al. Panmicrobial oligonucleotide array for diagnosis of infectious diseases. Emerg. Infect. Dis. 13(1), 73-81 (2007).
51. de Langen AJ, van Dillen J, de Witte P, Mucheto S, Nagelkerke N, Kager P. Automated detection of malaria pigment: feasibility for malaria diagnosing in an area with seasonal malaria in northern Namibia. Trop. Med. Int. Health 11(6), 809-816 (2006).
52. Grobusch MP, Hanscheid T, Kramer B et al. Sensitivity of hemozoin detection by automated flow cytometry in non- and semi-immune malaria patients. Cytometry B Clin. Cytom. 55(1), 46-51 (2003).
53. Hanscheid T, Pinto BG, Cristino JM, Grobusch MP. Malaria diagnosis with the haematology analyser Cell-Dyn 3500: what does the instrument detect? Clin. Lab. Haematol. 22(5), 259-261 (2000).
54. Hoffmann JJ, Pennings JM. Pseudo-reticulocytosis as a result of malaria parasites. Clin. Lab. Haematol. 21(4), 257-260 (1999).
55. Padial MM, Subirats M, Puente S et al. Sensitivity of laser light depolarization analysis for detection of malaria in blood samples. J. Med. Microbiol. 54(Pt 5), 449-452 (2005).
56. Scott CS, Van Zyl D, Ho E, Ruivo L, Kunz D, Coetzer TL. Patterns of pseudo-reticulocytosis in malaria fluorescent analysis with the Cell-Dyn CD4000. Clin. Lab. Haematol. 24(1), 15-20 (2002).
57. Suh IB, Kim HJ, Kim JY et al. Evaluation of the Abbott Cell-Dyn 4000 hematology analyzer for detection and therapeutic monitoring of Plasmodium vivax in the Republic of Korea. Trop Med. Int. Health. 8(12), 1074-1081 (2003).
58. Wever PC, Henskens YM, Kager PA, Dankert J, van Gool T. Detection of imported malaria with the Cell-Dyn 4000 hematology analyzer. J. Clin. Microbiol. 40(12), 4729-4731 (2002).
59. Dromigny JA, Jambou R, Scott CS, Perrier-Gros-Claude JD. Performance evaluation of automated depolarization analysis for detecting clinically unsuspected malaria in endemic countries. Trans. R. Soc. Trop. Med. Hyg. 99(6), 430-439 (2005).
60. Hanscheid T, Pinto BG, Pereira I, Cristino JM, Valadas E. Avoiding misdiagnosis of malaria a novel automated method allows specific diagnosis; even in the absence of clinical suspicion. Emerg. Infect. Dis. 5(6), 836-838 (1999).
61. Hanscheid T, Valadas E, Grobusch MP. Automated malaria diagnosis using pigment detection. Parasitol. Today 16(12), 549-551 (2000).
62. Fourcade C, Casbas MJ, Belaouni H, Gonzalez JJ, Garcia PJ, Pepio MA. Automated detection of malaria by means of the haematology analyser Coulter GEN.S. Clin. Lab. Haematol. 26(6), 367-372 (2004).
63. Briggs C, Da Costa A, Freeman L, Aucamp I, Ngubeni B, Machin SJ. Development of an automated malaria discriminant factor using VCS technology. Am J. Clin. Pathol. 126(5), 691-698 (2006).
64. Demirev PA, Feldman AB, Kongkasuriyachai D, Scholl P, Sullivan D Jr, Kumar N. Detection of malaria parasites in blood by laser desorption mass spectrometry. Anal. Chem. 74(14), 3262-3266 (2002).
65. Nyunt M, Pisciotta J, Feldman AB et al. Detection of Plasmodium falciparum in pregnancy by laser desorption mass spectrometry. Am. J. Top. Med. Hyg. 73(3), 485-490 (2005).
66. Scholl PF, Kongkasuriyachai D, Demirev PA et al. Rapid detection of malaria infection in vivo by laser desorption mass spectrometry. Am. J. Trop. Med. Hyg. 71(5), 546-551 (2004).
67. Makani J, Matuja W, Liyombo E, Snow RW, Marsh K, Warrell DA. Admission diagnosis of cerebral malaria in adults in an endemic area of Tanzania: implications and clinical description. QJM 96(5), 355-362 (2003).
68. Reyburn H, Mbatia R, Drakeley C et al. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. Br. Med. J. 329(7476), 1212 (2004).
69. Kallander K, Nsungwa-Sabiiti J, Peterson S. Symptom overlap for malaria and pneumonia - policy implications for home management strategies. Acta Trop. 90(2), 211-214 (2004).
70. O'Dempsey TJ, McArdle TF, Laurence BE, Lamont AC, Todd JE, Greenwood BM. Overlap in the clinical features of pneumonia and malaria in African children. Trans. R. Soc. Trop. Med. Hyg. 87(6), 662-665 (1993).
71. Reyburn H, Mbakilwa H, Mwangi R et al. Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial. Br. Med. J. 334(7590), 403 (2007).
72. Rolland E, Checchi F, Pinoges L, Balkan S, Guthmann JP, Guerin PJ. Operational response to malaria epidemics: are rapid diagnostic tests cost-effective? Trop. Med. Int. Health 11(4), 398-408 (2006).
73. Waters AP, McCutchan TF. Rapid, sensitive diagnosis of malaria based on ribosomal RNA. Lancet 1(8651), 1343-1346 (1989).
74. Barker RH Jr, Suebsaeng L, Rooney W, Alecrim GC, Dourado HV, Wirth DF. Specific DNA probe for the diagnosis of Plasmodium falciparum malaria. Science 231(4744), 1434-1436 (1986).
75. Holmberg M, Vaidya AB, Shenton FC et al. A comparison of two DNA probes, one specific for Plasmodium falciparum and one with wider reactivity, in the diagnosis of malaria. Trans. R. Soc. Trop. Med. Hyg. 84(2), 202-205 (1990).
76. Schindler HC, Montenegro L, Montenegro R, Carvalho AB, Abath FG, Jaureguiberry G. Development and optimization of polymerase chain reaction-based malaria diagnostic methods and their comparison with quantitative buffy coat assay. Am J. Trop. Med. Hyg. 65(4), 355-361 (2001).
77. Sethabutr O, Brown AE, Gingrich J et al. A comparative field study of radiolabeled and enzyme-conjugated synthetic DNA probes for the diagnosis of falciparum malaria. Am. J. Trop. Med. Hyg. 39(3), 227-231 (1988).
78. Lanar DE, McLaughlin GL, Wirth DF, Barker RJ, Zolg JW, Chulay JD. Comparison of thick films, in vitro culture and DNA hybridization probes for detecting Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg. 40(1), 3-6 (1989).
79. Barker RH Jr. DNA probe diagnosis of parasitic infections. Exp. Parasitol. 70(4), 494-499 (1990).
80. Barker RH Jr, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF. A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction. Am. J. Trop. Med. Hyg. 46(4), 416-426 (1992).
81. Oliveira DA, Shi YP, Oloo AJ et al. Field evaluation of a polymerase chain reaction-based nonisotopic liquid hybridization assay for malaria diagnosis. J. Infect. Dis. 173(5), 1284-1287 (1996).
82. Snounou G, Viriyakosol S, Jarra W, Thaithong S, Brown KN. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections. Mol. Biochem. Parasitol. 58(2), 283-292 (1993).
83. Snounou G, Viriyakosol S, Zhu XP et al. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol. Biochem. Parasitol. 61(2), 315-320 (1993).
84. Li J, Wirtz RA, McConkey GA et al. Plasmodium: genus-conserved primers for species identification and quantitation. Exp. Parasitol. 81(2), 182-190 (1995).
85. McCutchan TF, de la Cruz VF, Lal AA, Gunderson JH, Elwood HJ, Sogin ML. Primary sequences of two small subunit ribosomal RNA genes from Plasmodium falciparum. Mol. Biochem. Parasitol. 28(1), 63-68 (1988).
86. Humar A, Harrington MA, Kain KC. Evaluation of a non-isotopic polymerase chain reaction-based assay to detect and predict treatment failure of Plasmodium vivax malaria in travellers. Trans. R. Soc. Trop. Med. Hyg. 91(4), 406-409 (1997).
87. Kimura M, Miyake H, Kim HS et al. Species-specific PCR detection of malaria parasites by microtiter plate hybridization: clinical study with malaria patients. J. Clin. Microbiol. 33(9), 2342-2346 (1995).
88. Zhong KJ, Kain KC. Evaluation of a colorimetric PCR-based assay to diagnose Plasmodium falciparum malaria in travelers. J. Clin. Microbiol. 37(2), 339-341 (1999).
89. Farcas GA, Zhong KJ, Mazzulli T, Kain KC. Evaluation ofthe RealArt Malaria LC real-time PCR assay for malaria diagnosis. J. Clin. Microbiol. 42(2), 636-638 (2004).
90. Vo TK, Bigot P, Gazin P et al. Evaluation of a real-time PCR assay for malaria diagnosis in patients from Vietnam and in returned travellers. Trans. R. Soc. Trop. Med. Hyg. 101(5), 422-428 (2007).
91. Perandin F, Manca N, Calderaro A et al. Development of a real-time PCR assay for detection of Plasmodium falciparum, Plasmodium vivax, and Plasmodium ovale for routine clinical diagnosis. J. Clin. Microbiol. 42(3), 1214-1219 (2004).
92. Mens PF, Schoone GJ, Kager PA, Schallig HD. Detection and identification of human Plasmodium species with real-time quantitative nucleic acid sequence-based amplification. Malar. J. 5, 80 (2006).
93. Swan H, Sloan L, Muyombwe A et al. Evaluation of a real-time polymerase chain reaction assay for the diagnosis of malaria in patients from Thailand. Am. J. Trop. Med. Hyg. 73(5), 850-854 (2005).
94. Farcas GA, Soeller R, Zhong K, Zahirieh A, Kain KC. Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers. Clin. Infect. Dis. 42(5), 622-627 (2006).
95. Basco LK, Tahar R, Keundjian A. Ringwald P. Sequence variations in the genes encoding dihydropteroate synthase and dihydrofolate reductase and clinical response to sulfadoxine-pyrimethamine in patients with acute uncomplicated falciparum malaria. J. Infect. Dis. 182(2), 624-628 (2000).
96. Schwobel B, Alifrangis M, Salanti A, Jelinek T. Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker. Malar. J. 2, 5 (2003).
97. Palacios G, Quan PL, Jabado QJ et al. Panmicrobial oligonucleotide array for diagnosis of infectious diseases. Emerg. Infect. Dis. 13(1), 73-81 (2007).
98. de Langen AJ, van Dillen J, de Witte P, Mucheto S, Nagelkerke N, Kager P. Automated detection of malaria pigment: feasibility for malaria diagnosing in an area with seasonal malaria in northern Namibia. Trop. Med. Int. Health 11(6), 809-816 (2006).
99. Grobusch MP, Hanscheid T, Kramer B et al. Sensitivity of hemozoin detection by automated flow cytometry in non- and semi-immune malaria patients. Cytometry B Clin. Cytom. 55(1), 46-51 (2003).
100. Hanscheid T, Pinto BG, Cristino JM, Grobusch MP. Malaria diagnosis with the haematology analyser Cell-Dyn 3500: what does the instrument detect? Clin. Lab. Haematol. 22(5), 259-261 (2000).
101. Hoffmann JJ, Pennings JM. Pseudo-reticulocytosis as a result of malaria parasites. Clin. Lab. Haematol. 21(4), 257-260 (1999).
102. Padial MM, Subirats M, Puente S et al. Sensitivity of laser light depolarization analysis for detection of malaria in blood samples. J. Med. Microbiol. 54(Pt 5), 449-452 (2005).
103. Scott CS, Van Zyl D, Ho E, Ruivo L, Kunz D, Coetzer TL. Patterns of pseudo-reticulocytosis in malaria fluorescent analysis with the Cell-Dyn CD4000. Clin. Lab. Haematol. 24(1), 15-20 (2002).
104. Suh IB, Kim HJ, Kim JY et al. Evaluation of the Abbott Cell-Dyn 4000 hematology analyzer for detection and therapeutic monitoring of Plasmodium vivax in the Republic of Korea. Trop Med. Int. Health. 8(12), 1074-1081 (2003).
105. Wever PC, Henskens YM, Kager PA, Dankert J, van Gool T. Detection of imported malaria with the Cell-Dyn 4000 hematology analyzer. J. Clin. Microbiol. 40(12), 4729-4731 (2002).
106. Dromigny JA, Jambou R, Scott CS, Perrier-Gros-Claude JD. Performance evaluation of automated depolarization analysis for detecting clinically unsuspected malaria in endemic countries. Trans. R. Soc. Trop. Med. Hyg. 99(6), 430-439 (2005).
107. Hanscheid T, Pinto BG, Pereira I, Cristino JM, Valadas E. Avoiding misdiagnosis of malaria a novel automated method allows specific diagnosis; even in the absence of clinical suspicion. Emerg. Infect. Dis. 5(6), 836-838 (1999).
108. Hanscheid T, Valadas E, Grobusch MP. Automated malaria diagnosis using pigment detection. Parasitol. Today 16(12), 549-551 (2000).
109. Fourcade C, Casbas MJ, Belaouni H, Gonzalez JJ, Garcia PJ, Pepio MA. Automated detection of malaria by means of the haematology analyser Coulter GEN.S. Clin. Lab. Haematol. 26(6), 367-372 (2004).
110. Briggs C, Da Costa A, Freeman L, Aucamp I, Ngubeni B, Machin SJ. Development of an automated malaria discriminant factor using VCS technology. Am J. Clin. Pathol. 126(5), 691-698 (2006).
111. Demirev PA, Feldman AB, Kongkasuriyachai D, Scholl P, Sullivan D Jr, Kumar N. Detection of malaria parasites in blood by laser desorption mass spectrometry. Anal. Chem. 74(14), 3262-3266 (2002).
112. Nyunt M, Pisciotta J, Feldman AB et al. Detection of Plasmodium falciparum in pregnancy by laser desorption mass spectrometry. Am. J. Top. Med. Hyg. 73(3), 485-490 (2005).
113. Scholl PF, Kongkasuriyachai D, Demirev PA et al. Rapid detection of malaria infection in vivo by laser desorption mass spectrometry. Am. J. Trop. Med. Hyg. 71(5), 546-551 (2004).
114. Makani J, Matuja W, Liyombo E, Snow RW, Marsh K, Warrell DA. Admission diagnosis of cerebral malaria in adults in an endemic area of Tanzania: implications and clinical description. QJM 96(5), 355-362 (2003).
115. Reyburn H, Mbatia R, Drakeley C et al. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. Br. Med. J. 329(7476), 1212 (2004).
116. Kallander K, Nsungwa-Sabiiti J, Peterson S. Symptom overlap for malaria and pneumonia - policy implications for home management strategies. Acta Trop. 90(2), 211-214 (2004).
117. O'Dempsey TJ, McArdle TF, Laurence BE, Lamont AC, Todd JE, Greenwood BM. Overlap in the clinical features of pneumonia and malaria in African children. Trans. R. Soc. Trop. Med. Hyg. 87(6), 662-665 (1993).
118. Reyburn H, Mbakilwa H, Mwangi R et al. Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial. Br. Med. J. 334(7590), 403 (2007).