Why don't we move faster? Parkinson's disease, movement vigor, and implicit motivation

Journal of Neuroscience

Volumn 27, Issue 27, 2007, Pages 7105-7116

  Mazzoni, Pietro ^a   Hristova, Anna ^a   Krakauer, John W ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Bradykinesia; Dopamine; Motor planning; Movement time; Reward; Speed accuracy trade off

Indexed keywords

DOPAMINE;

ACCURACY; ADULT; AGED; ARTICLE; BRADYKINESIA; CLINICAL ARTICLE; CONTROL GROUP; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ENERGY COST; ENERGY EXPENDITURE; FEMALE; HUMAN; MALE; MOTIVATION; MOTOR PERFORMANCE; MOVEMENT (PHYSIOLOGY); PARKINSON DISEASE; PRIORITY JOURNAL; REWARD; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; VELOCITY;

ADULT; AGED; FEMALE; HUMANS; HYPOKINESIA; MALE; MIDDLE AGED; MOTIVATION; MOVEMENT; PARKINSON DISEASE; PHOTIC STIMULATION; PSYCHOMOTOR PERFORMANCE; REACTION TIME;

EID: 34447136107     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0264-07.2007     Document Type: Article

References (36)

1. Berardelli A, Rothwell JC, Thompson PD, Hallett M (2001) Pathophysiology of bradykinesia in Parkinson's disease. Brain 124:2131-2146.
2. Brumlik J, Boshes B (1966) The mechanism of bradykinesia in parkinsonism. Neurology 16:337-344.
3. England AC, Schwab RS (1961) Parkinson's syndrome. N Engl J Med 265:785-792.
4. Evarts EV, Teravainen H, Calne DB (1981) Reaction time in Parkinson's disease. Brain 104:167-186.
5. Fahn S, Elton RL, and the members of the UPDRS Development Committee (1987) Unified Parkinson's disease rating scale. In: Recent developments in Parkinson's disease II (Fahn S, Marsden CD, Goldstein M, Calne DB, eds), pp 153-163. New York: MacMillan.
6. Favilla M, Hening W, Ghez C (1989) Trajectory control in targeted force impulses. VI. Independent specification of response amplitude and direction. Exp Brain Res 75:280-294.
7. Fitts PM (1954) The information capacity of the human motor system in controlling the amplitude of movement. J Exp Psychol 47:381-391.
8. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
9. Graybiel AM (2005) The basal ganglia: learning new tricks and loving it. Curr Opin Neurobiol 15:638-644.
10. Hallett M (1990) Clinical neurophysiology of akinesia. Rev Neurol (Paris) 146:585-590.
11. Hallett M, Khoshbin S (1980) A physiological mechanism of bradykinesia. Brain 103:301-314.
12. Hatze H, Buys JD (1977) Energy-optimal controls in the mammalian neuromuscular system. Biol Cybern 27:9-20.
13. Hening W, Favilla M, Ghez C (1988) Trajectory control in targeted force impulses. V. Gradual specification of response amplitude. Exp Brain Res 71:116-128.
14. Jeannerod M (1986) Mechanisms of visuomotor coordination: a study in normal and brain-damaged subjects. Neuropsychologia 24:41-78.
15. Kish SJ, Shannak K, Hornykiewicz O (1988) Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. N Engl J Med 318:876-880.
16. Kording KP, Fukunaga I, Howard IS, Ingram JN, Wolpert DM (2004) A neuroeconomics approach to inferring utility functions in sensorimotor control. PLoS Biol 2:e330.
17. Majsak MJ, Kaminski T, Gentile AM, Flanagan JR (1998) The reaching movements of patients with Parkinson's disease under self-determined maximal speed and visually cued conditions. Brain 121:755-766.
18. McClure SM, York MK, Montague PR (2004) The neural substrates of reward processing in humans: the modern role of FMRI. Neuroscientist 10:260-268.
19. Montgomery Jr EB, Nuessen J (1990) The movement speed/accuracy operator in Parkinson's disease. Neurology 40:269-272.
20. Morrish PK, Sawle GV, Brooks DJ (1996) An [18F]dopa-PET and clinical study of the rate of progression in Parkinson's disease. Brain 119:585-591.
21. Niv Y, Joel D, Dayan P (2006) A normative perspective on motivation. Trends Cogn Sci 10:375-381.
22. Niv Y, Daw ND, Joel D, Dayan P (2007) Tonic dopamine: opportunity costs and the control of response vigor. Psychopharmacology (Berl) 191:507-520.
23. Phillips JG, Martin KE, Bradshaw JL, Iansek R (1994) Could bradykinesia in Parkinson's disease simply be compensation? J Neurol 241:439-447.
24. Reinsch CH (1967) Smoothing by spline functions. Numerische Math 10:177-183.
25. Sainburg RL, Ghez C, Kalakanis D (1999) Intersegmental dynamics are controlled by sequential anticipatory, error correction, and postural mechanisms. J Neurophysiol 81:1045-1056.
26. Schmidt RA, Zelaznik H, Hawkins B, Frank JS, Quinn JT (1979) Motor-output variability: a theory for the accuracy of rapid motor acts. Psychol Rev 86:415-451.
27. Schultz W (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80:1-27.
28. Schultz W (2006) Behavioral theories and the neurophysiology of reward. Annu Rev Psychol 57:87-115.
29. Sheridan MR, Flowers KA (1990) Movement variability and bradykinesia in Parkinson's disease. Brain 113:1149-1161.
30. Silverman BW (1986) Density estimation for statistics and data analysis. London: Chapman and Hall.
31. Sokal RR, Rohlf FJ (1981) Biometry: the principles and practice of statistics in biological research, Ed 2. New York: Freeman.
32. Tanaka H, Krakauer JW, Qian N (2006) An optimization principle for determining movement duration. J Neurophysiol 95:3875-3886.
33. Todorov E (2004) Optimality principles in sensorimotor control. Nat Neurosci 7:907-915.
34. Todorov E, Jordan MI (2002) Optimal feedback control as a theory of motor coordination. Nat Neurosci 5:1226-1235.
35. Winter DA (1990) Biomechanics and motor control of human movement. New York: Wiley.
36. Woodworth RS (1899) The accuracy of voluntary movement. Psychol Rev 3 [Suppl 13]:1-119.