Preparation of codeine-resinate and chlorpheniramine-resinate sustained-release suspension and its pharmacokinetic evaluation in beagle dogs

Drug Development and Industrial Pharmacy

Volumn 33, Issue 6, 2007, Pages 649-665

  Zeng, Huan Xiang ^a   Cheng, Gang ^a   Pan, Wei San ^a   Zhong, Guo Ping ^b   Huang, Min ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Chlorpheniramine; Coating; Codeine; Ion exchange resins; Oral suspension; Pharmacokinetics; Sustained release; Wurster process

Indexed keywords

ALCOHOL; CHLORPHENIRAMINE; CODEINE; DICHLOROMETHANE; ETHYL CELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; LORATADINE; MACROGOL 4000; METHYLCELLULOSE; PHTHALIC ACID DIBUTYL ESTER; PLASTICIZER; POLACRILIN; POLYMER; POTASSIUM CHLORIDE; RESIN; SOLVENT; XANTHAN;

ACCURACY; AIR TEMPERATURE; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; ATMOSPHERIC PRESSURE; BATCH PROCESS; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG COATING; DRUG EFFICACY; DRUG RELEASE; DRUG SAFETY; FEMALE; IONIC STRENGTH; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; REFERENCE VALUE; SINGLE DRUG DOSE; SUSPENSION; SUSTAINED DRUG RELEASE; TABLET; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VISCOSITY;

ANALGESICS, OPIOID; ANIMALS; BIOLOGICAL AVAILABILITY; CHLORPHENIRAMINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CODEINE; DELAYED-ACTION PREPARATIONS; DOGS; DRUG CARRIERS; DRUG COMPOUNDING; HISTAMINE H1 ANTAGONISTS; ION EXCHANGE RESINS; OSMOLAR CONCENTRATION; POLYETHYLENE GLYCOLS; RANDOM ALLOCATION; RESINS, SYNTHETIC; SUSPENSIONS; TANDEM MASS SPECTROMETRY;

EID: 34447135504     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040601050221     Document Type: Article

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