A proteomic method for analysis of CYP450s protein expression changes in carbon tetrachloride induced male rat liver microsomes

Toxicology

Volumn 237, Issue 1-3, 2007, Pages 1-11

  Jia, Nuan ^a   liu, Xin ^b   Wen, Jun ^a   Qian, Linyi ^b   Qian, Xiaohong ^b   Wu, Yutian ^a   Fan, Guorong ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Carbon tetrachloride; Cytochrome(s) P450; Hepatic injury; Proteomics; Quantitative

Indexed keywords

CARBON TETRACHLORIDE; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2C11; CYTOCHROME P450 2C6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A2; STABLE ISOTOPE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BLOOD CHEMISTRY; CONTROLLED STUDY; CORRELATION COEFFICIENT; DOWN REGULATION; HISTOPATHOLOGY; INFRARED SPECTROSCOPY; ISOTOPE LABELING; LIVER INJURY; LIVER MICROSOME; LIVER TOXICITY; MALE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEOMICS; QUANTITATIVE ANALYSIS; RAT; UPREGULATION;

AFFINITY LABELS; AMINO ACID SEQUENCE; ANIMALS; CARBON TETRACHLORIDE; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ISOENZYMES; ISOTOPE LABELING; LIVER; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; NECROSIS; PEPTIDE BIOSYNTHESIS; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS;

RATTUS;

EID: 34447134883     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.04.015     Document Type: Article

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