Dermatological toxicity of hexavalent chromium

Critical Reviews in Toxicology

Volumn 37, Issue 5, 2007, Pages 375-387

  Shelnutt, Susan R ^a   Goad, Phillip ^a   Belsito, Donald V ^b,c  

^a Center for Toxicology and Environmental Health   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c NONE   (United States)

Author keywords

Allergic Contact Dermatitis; Minimum Elicitation Threshold; Skin Ulcers

Indexed keywords

CHROMIUM; DETERGENT; DICHROMATE POTASSIUM; NICKEL; PLACEBO;

CONCENTRATION RESPONSE; CONSUMER; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; HISTOPATHOLOGY; HUMAN; LONG TERM EXPOSURE; OCCUPATIONAL EXPOSURE; PATCH TEST; POPULATION RESEARCH; PREVALENCE; PROGNOSIS; REVIEW; SAFETY; SKIN ALLERGY; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; SKIN ULCER; STRUCTURE ACTIVITY RELATION;

CHROMIUM; DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; PREVALENCE; PROGNOSIS; SKIN ULCER;

EID: 34447128298     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440701266582     Document Type: Review

References (77)

1. Allenby, C.F., and Goodwin, B.F. (1983). Influence of detergent washing powders on minimal eliciting patch test concentrations of nickel and chromium. Contact Dermatitis 9(6):491-499.
2. Andersen, P. H., Nangia, A., Bjerring, P., and Maibach, H. I. (1991). Chemical and pharmacologic skin irritation in man: A reflectance spectroscopic study. Contact Dermatitis 25(5):283-289.
3. Anderson, R.A., and Kozlovsky, A.S. (1985). Chromium intake, absorption and excretion of subjects consuming self-selected diets. Am. J. Clin. Nutr. 41(6):1177-1183.
4. Bagdon, R.E., and Hazen, R.E. (1991). Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant. Environ. Health Perspect. 92:111-119.
5. Basketter, D., Horev, L., Slodovnik, D., Merimes, S., Trattner, A., and Ingber, A. (2001). Investigation of the threshold for allergic reactivity to chromium. Contact Dermatitis 44(2):70-74.
6. Basketter, D.A., Briatico-Vangosa, G., Kaestner, W., Lally, C., and Bontinck, W.J. (1993). Nickel, cobalt and chromium in consumer products: A role in allergic contact dermatitis? Contact Dermatitis 28(1):15-25.
7. Belsito, D.V. (2003) Allergic Contact dermatitis. In: Fitzpatrick's dermatology in general medicine, 6th ed., I. M. Freedberg et al., eds., pp. 1164-1177. McGraw-Hill, New York.
8. Belsito, D.V. (2000). The diagnostic evaluation, treatment, and prevention of allergic contact dermatitis in the new millennium. J. Allergy Clin. Immunol. 105(3):409-420.
9. Breit, R., and Turk, R.B. (1976). The medical and social fate of the dichromate allergic patient. Br. J. Dermatol. 94(3):349-350.
10. Burrows, D. (1983). Adverse chromate reactions on the skin. In: Chromium: Metabolism and toxicity, D. Burrows, ed., pp. 137-163. CRC Press, Boca Raton, FL.
11. Calnan, C. D. (1962). Cement dermatitis. In: Symposium Dermatologorum, pp. 232-238. Universitas Carolina, Prague.
12. Christophersen, J., Menne, T., Tanghoj, P., Andersen, K.E., Brandrup, F., Kaaber, K., Osmundsen, P.E., Thestrup-Pedersen, K., and Veien, N.K. (1989). Clinical patch test data evaluated by multivariate analysis. Danish Contact Dermatitis Group. Contact Dermatitis 21(5):291-299.
13. Cohen, D. E and Brancaccio, R. (2000). Response to "Patch testing for chromium sensitivity." Am. J. Contact Dermatitis 11(2):123-125.
14. Cuadra, J., Latasa, J.M., Botella, R., and Hidalgo, F. (1982). [Histopathological aspects of chromium ulcers]. Med. Cutan. Ibero Lat. Am. 10(6):361-364.
15. DaCosta, J.C., Jones, J.F.X., and Rosenberger, R.C. (1916). Tanners' ulcer. Chrome sores - chrome holes - acid bites. Ann. Surg. 63:155-166.
16. De Raeve, H., Vandecasteele, C., Demedts, M., and Nemery, B. (1998). Dermal and respiratory sensitization to chromate in a cement floorer. Am. J. Ind. Med. 34(2):169-176.
17. EEC. (1976). Council Directive 76/768/EEC of 27 July 1976 on the approximation of laws of Member States relating to cosmetic products. European Economic Council, Brussels, Belgium.
18. Eun, H.C., and Marks, R. (1990). Dose-response relationships for topically applied antigens. Br. J. Dermatol. 122(4):491-499.
19. Fagliano, J. A., and Savrin, J. E. (1994). Chromium medical surveillance project: Final technical report. New Jersey Department of Health, Trenton.
20. Fagliano, J.A., Savrin, J., Udasin, I., and Gochfeld, M. (1997). Community exposure and medical screening near chromium waste sites in New Jersey. Regul. Toxicol. Pharmacol. 26(1 Pt 2):S13-S22.
21. Feuerman, E. (1971). Chromates as the cause of contact dermatitis in housewives. Dermatologica 143(5):292-297.
22. Finley, B.L., Paustenbach, D.J., Nethercott, J., and Fowler, J. (1995). Risk assessment of the allergic dermatitis potential of environmental exposure to hexavalent chromium. J. Toxicol. Environ. Health 44(3):377-383.
23. Finley, B.L., Proctor, D.M., Harris, M., and Fowler, J. (2000). Patch testing for chromium sensitivity. Am. J. Contact Dermatitis 11(2):121-123.
24. Fowler, J.F. (2000). Systemic contact dermatitis caused by oral chromium picolinate. Cutis 65(2):116.
25. Fowler, J. F. Jr., Kauffman, C. L., Marks, J. G. Jr., Proctor, D. M., Fredrick, M. M., Otani, J. M., Finley, B. L., Paustenbach, D. J., and Nethercott, J. R. (1999). An environmental hazard assessment of low-level dermal exposure to hexavalent chromium in solution among chromium-sensitized volunteers. J. Occup. Environ. Med. 41(3):150-160.
26. Fregert, S. (1965). Sensitization to hexa- and trivalent chromium. In: Pemphigus; Occupational dermatoses due to chemical sensitization, E. Liebner and E. Florian, eds., pp. 50-55. Congress of the Hungarian Dermatological Society, Budapest.
27. Fregert, S. (1975). Occupational dermatitis in a 10-year material. Contact Dermatitis 1(2):96-107.
28. Fregert, S., and Ovrum, P. (1963). Chromate in welding fumes with special reference to contact dermatitis. Acta Derm. Venereol. 43:119-124.
29. Friedmann, P.S. (1990). The immunology of allergic contact dermatitis: the DNCB story. Adv. Dermatol. 5:175-195; discussion 196.
30. Gammelgaard, B., Fullerton, A., Avnstorp, C., and Menne, T. (1992). Permeation of chromium salts through human skin in vitro. Contact Dermatitis 27(5):302-310.
31. Goh, C.L., Gan, S.L., and Ngui, S.J. (1986). Occupational dermatitis in a prefabrication construction factory. Contact Dermatitis 15(4):235-240.
32. Guo, Y.L., Wang, B.J., Yeh, K.C., Wang, J.C., Kao, H.H., Wang, M.T., Shih, H.C., and Chen, C.J. (1999). Dermatoses in cement workers in southern Taiwan. Contact Dermatitis 40(1):1-7.
33. Hicks, R., Hewitt, P.J., and Lam, H.F. (1979). An investigation of the experimental induction of hypersensitivity in the guinea pig by material containing chromium, nickel and cobalt from arc welding fumes. Int. Arch. Allergy Appl. Immunol. 59(3):265-272.
34. Hostynek, J.J., and Maibach, H.I. (1988). Chromium in US household bleach. Contact Dermatitis 18(4):206-209.
35. Hovding, G. (1970). Cement eczema and chromium allergy: An epidemiological investigation. University of Bergen, Oslo, Norway.
36. Kiec-Swierczynska, M. (1990). Occupational dermatoses and allergy to metals in Polish construction workers manufacturing prefabricated building units. Contact Dermatitis 23(1):27-32.
37. Kligman, A.M. (1966). The identification of contact allergens by human assay. 3. The maximization test: A procedure for screening and rating contact sensitizers. J. Invest. Dermatol. 47(5):393-409.
38. Kosann, M.K., Brancaccio, R.R., Shupack, J.L., Franks, A.G.J., and Cohen, D.E. (1998). Six-hour versus 48-hour patch testing with varying concentrations of potassium dichromate. Am. J. Contact Dermatitis 9(2):92-95.
39. Kumpulainen, J.T., Wolf, W.R., Veillon, C., and Mertz, W. (1979). Determination of chromium in selected United States diets. J. Agric. Food Chem. 27(3):490-494.
40. Lammintausta, K., Pitkanen, O.P., Kalimo, K., and Jansen, C.T. (1985). Interrelationship of nickel and cobalt contact sensitization. Contact Dermatitis 13(3):148-152.
41. Lantinga, H., Nater, J.P., and Coenraads, P.J. (1984). Prevalence, incidence and course of eczema on the hands and forearms in a sample of the general population. Contact Dermatitis 10(3):135-139.
42. Liden, S., and Lundberg, E. (1979). Penetration of chromium in intact human skin in vivo. J. Invest. Dermatol. 72(1):42-45.
43. Marks, J.G., Belsito, D.V., DeLeo, V.A., Fowler, J.F.J., Fransway, A.F., Maibach, H.I., Mathias, C.G., Nethercott, J.R., Rietschel, R.L., Rosenthal, L.E., Sherertz, E.F., Storrs, F.J. , & Taylor, J.S. (1995). North American Contact Dermatitis Group standard tray patch test results (1992 to 1994). Am. J. Contact Dermatitis 6(3):160-165.
44. Marks, J.G., Belsito, D.V., DeLeo, V.A., Fowler, J.F.J., Fransway, A.F., Maibach, H.I., Mathias, C.G., Nethercott, J.R., Rietschel, R.L., Sherertz, E.F., Storrs, F.J., and Taylor, J.S. (1998). North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens. J. Am. Acad. Dermatol. 38(6 pt 1):911-918.
45. Marks, J.G. Jr., Belsito, D.V., DeLeo, V.A., Fowler, J.F.J., Fransway, A.F., Maibach, H.I., Mathias, C.G., Pratt, M.D., Rietschel, R.L., Sherertz, E.F., Storrs, F.J., and Taylor, J.S. (2000). North American Contact Dermatitis Group patch-test results, 1996-1998. Arch. Dermatol. 136(2):272- 273.
46. Marks, J.G. Jr., Belsito, D.V., DeLeo, V.A., Fowler, J.F.Jr., Fransway, A.F., Maibach, H.I., Mathias, C.G., Pratt, M.D., Rietschel, R.L., Sherertz, E.F., Storrs, F.J., & Taylor, J.S. (2003). North American Contact Dermatitis Group patch-test results, 1998 to 2000. Am. J. Contact Dermatitis 14(2):59-62.
47. Nethercott J.R. (1990). Practical Problems in the Use of Patch Testing In the Evaluation of Patients with Contact Dermatitis. Curr. Problems Dermatol. 2:95-123.
48. Nethercott, J.R., Holness, D.L., Adams, R.M., Belsito, D.V., De Leo, V.A., Emmett, E.A., et al. (1991). Patch testing with a routine screening tray in North America 1985-1989. 1. Frequency of response. Am. J. Contact Dermatitis 2:122-129.
49. Nethercott, J., Paustenbach, D., Adams, R., Fowler, J., Marks, J., Morton, C., Taylor, J., Horowitz, S., and Finley, B. (1994). A study of chromium induced allergic contact dermatitis with 54 volunteers: implications for environmental risk assessment. Occup. Environ. Med. 51(6):371-380.
50. Nielsen, N.H., and Menne, T. (1992). Allergic contact sensitization in an unselected Danish population. The Glostrup Allergy Study, Denmark. Acta Derm. Venereol. 72(6):456-460.
51. Nielsen, N.H., Kristiansen, J., Borg, L., Christensen, J.M., Poulsen, L.K., and Menne, T. (2000). Repeated exposures to cobalt or chromate on the hands of patients with hand eczema and contact allergy to that metal. Contact Dermatitis 43(4):212-215.
52. Paustenbach, D.J., Sheehan, P.J., Paull, J.M., Wisser, L.M., & Finley, B.L. (1992). Review of the allergic contact dermatitis hazard posed by chromium-contaminated soil: Identifying a "safe" concentration. J. Toxicol. Environ. Health. 37(1):177-207.
53. Polak, L. (1983). Immunology of chromium. In: Chromium: Metabolism and toxicity, D. Burrows, ed., pp. 51-136. CRC Press, Boca Raton, FL.
54. Pratt, M.D., Belsito, D.V., DeLeo, V.A., Fowler, J.F.J., Fransway, A.F., Maibach, H.I., Marks, J.G., Mathias, C.G., Rietschel, R.L., Sasseville, D., Sherertz, E.F., Storrs, F.J., Taylor, J.S., and Zug, K. (2004). North American Contact Dermatitis Group patch-test results, 2001-2002 study period. Dermatitis 15(4):176-183.
55. Proctor, D.M., Fredrick, M.M., Scott, P.K., Paustenbach, D.J., and Finley, B.L. (1998). The prevalence of chromium allergy in the United States and its implications for setting soil cleanup: A cost-effectiveness case study. Regul. Toxicol. Pharmacol. 28(1):27-37.
56. Quinones, P.A., and Garcia Munoz, C.M. (1965). [Allergic contact sensitizations to nickel and chromium: Presence of these metallic elements in commercial detergents for household use]. Ann. Dermatol. Syphiligr. (Paris) 92(4):383-386.
57. Rudner, E.J., Clendenning, W.E., Epstein, E., Fisher, A.A., Jillson, O.F., et al. (1973). Epidemiology of contact dermatitis in North America: 1972. Arch. Dermatol. 108:537-540.
58. Rudolf, E., Cervinka, M., Cerman, J., and Schroterova, L. (2005). Hexavalent chromium disrupts the actin cytoskeleton and induces mitochondria-dependent apoptosis in human dermal fibroblasts. Toxicol In Vitro. 19(6):713-723.
59. Rudzki, E., and Prystupa, K. (1994). Sensitivity to various nickel and chromium concentrations in patch tests and oral challenge tests. Contact Dermatitis 30(4):254-255.
60. Ruff, C.A. and Belsito, D.V. (2006). The impact of various patient factors on contact allergy to nickel, cobalt, and chromate. J. Am. Acad. Dermatol. 55(1):32-9.
61. Samitz, M.H., Katz, S., and Shrager, J.D. (1967). Studies of the diffusion of chromium compounds through skin. J. Invest. Dermatol. 48(6):514-520.
62. Sertoli, A., Lombardi, P., Francalanci, S., Gola, M., Giorgini, S., and Panconesi, E. (1985). [Effect of oral administration of haptens in sensitized subjects with contact allergic eczema. II). Personal contribution]. G. Ital. Dermatol. Venereol. 120(3):213-218.
63. Shelley, W.B. (1964). Chromium in welding fumes as cause of eczematous hand eruption. J . Am. Med. Assoc. 189:772-773.
64. Stern, A.H., Bagdon, R.E., Hazen, R.E., and Marzulli, F.N. (1993). Risk assessment of the allergic dermatitis potential of environmental exposure to hexavalent chromium. J. Toxicol. Environ. Health 40(4):613-641.
65. Storrs, F.J., Rosenthal, L.E., Adams, R.M., Clendenning, W., Emmett, E.A., Fisher, A.A., Larsen, W.G., Maibach, H.I., Rietschel, R.L., Schorr, W.F., et al. (1989). Prevalence and relevance of allergic reactions in patients patch tested in North America - 1984 to 1985. J. Am. Acad. Dermatol. 20(6):1038-1045.
66. Tsai, T.F., and Maibach, H.I. (1999). How irritant is water? An overview. Contact Dermatitis 41(6):311-314.
67. van Ketel, W.G. (1984). Low incidence of occupational dermatitis from chromate. Contact Dermatitis 10(4):249
68. Veien, N.K. (1989). Systemically induced eczema in adults. Acta Derm. Venereol. Suppl. (Stockh.) 147:1-58.
69. Veien, N.K., Hattel, T., and Laurberg, G. (1994). Chromate-allergic patients challenged orally with potassium dichromate. Contact Dermatitis 31(3):137-139.
70. Wahlberg, J.E. (1968). Percutaneous absorption from chromium (51Cr) solutions of different pH, 1.4-12.8. An experimental study in the guinea pig. Dermatologica 137(1):17-25.
71. Wahlberg, J.E. (1973). Thresholds of sensitivity in metal contact allergy. 2. The value of percutaneous absorption studies for selection of the most suitable vehicle. Berufsdermatosen 21(4):151-158.
72. Waldorf, H.A., Walsh, L.J., Schechter, N.M., and Murphy, G.F. (1991). Early cellular events in evolving cutaneous delayed hypersensitivity in humans. Am. J. Pathol. 138(2):477-486.
73. Walsh, E. N. (1953). Chromate hazards in industry. Council on Industrial Health, American Medical Association, Chicago.
74. Wass, U., and Wahlberg, J.E. (1991). Chromated steel and contact allergy. Recommendation concerning a "threshold limit value" for the release of hexavalent chromium. Contact Dermatitis 24(2):114-118.
75. Zaczkiewicz, A., and Czerwinska-Dihm, I. (1994). [Occupational skin diseases from material of the Regional Center for Occupational Medicine collected during the years 1979-1991]. Med. Pr. 45(4):311-318.
76. Zelger, J. (1964). [On the clinical aspects and pathogenesis of chromate eczema.]. Arch. Klin. Exp. Dermatol. 218:499-542.
77. Zhang, J.D., and Li, X.L. (1987). [Chromium pollution of soil and water in Jinzhou]. Zhonghua Yu Fang Yi Xue Za Zhi (Chin. J. Prev. Med.) 21(5):262-264.