Aqueous and vitreous penetration of levofloxacin after topical and/or oral administration

European Journal of Ophthalmology

Volumn 17, Issue 3, 2007, Pages 372-376

  Sakamoto, Hidehisa ^a,b   Sakamoto, M ^a   Hata, Y ^a   Kubota, T ^a   Ishibashi, T ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NONE   (Japan)

Author keywords

Aqueous and vitreous penetration; Levofloxacin; MIC90; Ocular infections; Oral administration; Topical application

Indexed keywords

LEVOFLOXACIN; ANTIINFECTIVE AGENT; OFLOXACIN;

ADULT; AQUEOUS HUMOR; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG POTENCY; EYE INFECTION; FEMALE; HUMAN; MALE; PHACOEMULSIFICATION; PRIORITY JOURNAL; VITRECTOMY; VITREOUS BODY; AGED; BACTERIUM; BIOAVAILABILITY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MICROBIOLOGICAL EXAMINATION; MIDDLE AGED; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; AGED; ANTI-BACTERIAL AGENTS; AQUEOUS HUMOR; BACTERIA; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; OFLOXACIN; PHACOEMULSIFICATION; VITRECTOMY; VITREOUS BODY;

EID: 34447126902     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.1177/112067210701700316     Document Type: Article

References (11)

1. Ernst ME, Ernst EJ, Klepser ME. Levofloxacin and trovafloxacin: the next generation of fluoroquinolones. Am J Health Syst Pharm 1997; 54: 2569-84.
2. Fimer SM, Schoonover L, Garrison ME. Levofloxacin: a therapeutic review. Clin Ther 1998; 20: 1049-70.
3. Kresloff MS, Castellarin AA, Zarbin MA. Endophthalmitis. Surv Ophthalmol 1998; 43: 193-224.
4. Cekic O, Batman C, Yasar U, Basci NE, Bozkurt A, Kayaalp O. Penetration of ofloxacin in human aqueous and vitreous humors following oral and topical administration. Retina 1998; 18: 521-5.
5. Donnenfeld ED, Perry HD, Synder RW, Moadel K, Elsky M, Jones H. Intracorneal, aqueous humor, and vitreous humor penetration of topical and oral ofloxacin. Arch Ophthalmol 1997; 115: 173-6.
6. Fiscella RG, Shapiro MJ, Solomon MJ, Kurtz RM, Mui S, Labib S. Ofloxacin penetration into the eye after intravenous and topical administration. Retina 1997; 17: 535-9.
7. Fiscella RG, Nguyen TKP, Cwik MJ, et al. Aqueous and vitreous penetration of levofloxacin after oral administration. Ophthalmology 1999; 106: 2286-90.
8. Grannenman GR, Varga LL. High-performance liquid chromatographic procedures for the determination of temafloxacin in biological matrices. J Chromatogr 1991; 568: 197-206.
9. Donnenfeld ED, Schrier A, Perry HD, Aulicino T, Gombert ME, Snyder R. Penetration of topically applied ciprofloxacin, norfloxacin, and ofloxacin into aqueous humor. Ophthalmology 1994; 101: 902-5.
10. Vergraeken H, Verstraete A, Van de Velde E, Verschraegen G. Penetration of gentamicin and ofloxacin in human vitreous after systemic administration. Graefes Arch Clin Exp Ophthalmol 1996; 234 (Suppl): S59-65.
11. Fiscella RG, Gicser J, Phillpotts B, et al. Intraocular penetration of gentamicin after once-daily aminoglycoside dosing. Retina 1998; 18: 339-42.