Effects of testosterone therapy on cardiovascular risk markers in androgen-deficient women with hypopituitarism

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 7, 2007, Pages 2474-2479

  Miller, Karen K ^a   Biller, B M K ^a   Schaub, A ^a   Pulaski Liebert, K ^a   Bradwin, G ^b   Rifai, N ^b   Klibanski, A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; C REACTIVE PROTEIN; HOMOCYSTEINE; PLACEBO; TESTOSTERONE; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ANDROGEN DEFICIENCY; ARTICLE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE MARKER; DOSE RESPONSE; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GROUPS BY AGE; HOMEOSTASIS; HORMONE SUBSTITUTION; HUMAN; HYPOPITUITARISM; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LOW DRUG DOSE; MEDICAL RESEARCH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SINGLE BLIND PROCEDURE; TESTOSTERONE BLOOD LEVEL; TRANSDERMAL PATCH;

EID: 34447120712     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-0195     Document Type: Article

References (44)

1. Miller K, Biller B, Beauregard C, Lipman J, Jones J, Schoenfeld D, Sherman J, Swearingen B, Loeffler J, Klibanski A 2006 Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 91:1683-1690
2. Shifren J, Braunstein G, Simon J, Casson P, Buster J, Redmond G, Burki R, Ginsburg E, Rosen R, Leiblum S, Caramelli K, Mazer N 2000 Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 343:682-688
3. Shifren J, Davis S, Moreau M, Waldbaum A, Bouchard C, Derogatis L, Derzko C, Bearnson P, Kakos N, O'neill S, Levine S, Wekselman K, Buch A, Rodenberg C, Kroll R 2006 Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study. Menopause 13:770-779
4. Braunstein G, Sundwall D, Katz M, Shifren J, Buster J, Simon J, Bachman G, Aguirre O, Lucas J, Rodenberg C, Buch A, Watts N 2005 Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 165:1571-1572
5. Buster J, Kingsberg S, Aguirre O, Brown C, Breaux J, Buch A, Rodenberg C, Wekselman K, Casson P 2005 Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 105:938-940
6. Davis S, van der Mooren M, van Lunsen R, Lopes P, Ribot J, Rees M, Moufarege A, Rodenberg C, Buch A, Purdie D 2006 Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause 13:387-396
7. Dahlgren E, Janson P, Johannson S, Lapidus L, Oden A 1992 Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women. Acta Obstet Gynecol Scand 71:599-604
8. Wu FC, von Eckardstein A 2003 Androgens and coronary artery disease. Endocr Rev 24:183-217
9. Koutkia P, Canavan B, Breu J, Torriani M, Kissko J, Grinspoon S 2004 Growth hormone-releasing hormone in HIV-infected men with lipodystrophy. JAMA 292:210-218
10. Marcovina SM, Albers JJ, Scanu AM, Kennedy H, Giaculli F, Berg K, Couderc R, Dati F, Rifai N, Sakurabayashi I, Tate JR, Steinmetz A 2000 Use of a reference material proposed by the International Federation of Clinical Chemistry and Laboratory Medicine to evaluate analytical methods for the determination of plasma lipoprotein(a). Clin Chem 46:1956-1967
11. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M 2000 Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23:57-63
12. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ 2000 Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410
13. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
14. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR 2002 Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 347:1557-1565
15. Pierpont T, McKeigue P, Isaacs A, Wild S, Jacobs H 1998 Mortality of women with polycystic ovary syndrome at long-term follow-up. J Clin Epidemiol 51:581-586
16. Wild S, Pierpont T, McKeigue P, Jacobs H 2000 Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study. Clin Endocrinol (Oxf) 52:595-600
17. Toda T, Toda Y, Cho B, Kummerow F 1984 Ultrastructural changes in the comb and aorta of chicks fed excess testosterone. Atherosclerosis 51:47-53
18. Larsen B, Nordestgaard B, Stender S, Kjeldsen K 1993 Effect of testosterone on atherogenesis in cholesterol-fed rabbits wtih similar plasma cholesterol levels. Atherosclerosis 99:79-86
19. Adams M, Williams J, Kaplan J 1995 Effects of androgens on coronary atherosclerosis and atherosclerosis-related impairment of vascular responsiveness. Arterioscler Thromb Vasc Biol 15:562-570
20. Bruck B, Brehme U, Gugel N, Hanke S, Finking G, Lutz C, Benda N, Schmahl F, Hassis R, Hanke H 1997 Gender-specific differences in the effects of testosterone and estrogen on the developmen of atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol 17:2192-2199
21. Alexandersen P, Haarbo J, Byrjalsen I, Laweatz H, Christiansen C 1999 Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits. Circ Res 84:813-819
22. Herbst KL, Calof OM, Hsia SH, Sinha-Hikim I, Woodhouse LJ, Buchanan TA, Bhasin S 2006 Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss. Fertil Steril 85:1794-1802
23. Singh AB, Hsia S, Alaupovic P, Sinha-Hikim I, Woodhouse L, Buchanan TA, Shen R, Bross R, Berman N, Bhasin S 2002 The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men. J Clin Endocrinol Metab 87:136-143
24. Whitsel E, Boyko E, Matsumoto AM, Anawalt BD, Siscovick D 2001 Intramuscular testosterone esters and plasma lipids in hypogonadal men: a metaanalysis. Am J Med 111:261-269
25. McCrohon J, Jessup W, Handelsman D, Celermajer D 1999 Androgen exposure increase humah monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1. Circulation 99:2317-2322
26. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
27. Mukherjee T, Dinh H, Chaudhuri G, Nathan L 2002 Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis. Proc Natl Acad Sci USA 99:4055-4060
28. Mulligan K, Grunfeld C, Hellerstein MK, Neese RA, Schambelan M 1993 Anabolic effects of recombinant human growth hormone in patients with wasting associated with human immunodeficiency virus infection. J Clin Endocrinol Metab 77:956-962
29. Stein J, Rosenson R 1997 Lipoprotein Lp(a) excess and coronary heart disease. Arch Intern Med 157:1170-1176
30. von Eckardstein A, Schulte H, Cullen P, Assmann G 2001 Lipoprotein(a) further incresaes the risk of coronary events in men with high global cardiovascular risk. J Am Coll Cardiol 37:2434-2439
31. Hobbs H, White A 1999 Lipoprotein(a): intrigues and insights. Curr Opin Lipidol 10:225-236
32. Andersen R, Wallace E, Wu F 1995 Effect of testosterone enanthate on serum lipoproteins in man. Contraception 52:115-119
33. Zmuda J, Thompson P, Dickenson R, Bausserman L 1996 Testosterone decreases lipoprotein(a) in men. Am J Cardiol 77:1244-1247
34. Snyder P, Peachy H, Berlin J, Hannousch P, Haddad G, Dlewati A, Santanna J, Loh L, Lenrow D, Holmes J, Kapoor S, Atkinson L 2000 Effects of testosterone replacement in hypogonadal men. J Clin Endocrinol Metab 85:2670-2677
35. Yesilova Z, Ozata M, Oktenli C, Sanisoglu S, Erbil M, Dagalp K 2004 Effect of supraphysiologic doses of testosterone on fasting plasma total homocysteine concentrations in men with Klinefelter's syndrome. Fertil Steril 81:1278-1282
36. Oktenli C, Yesilova Z, Ozata M, Yaman H, Tuzun A, Dundar S, Sanisoglu S, Musabak U, Erbil M, Dagalp K 2003 Gondatropin treatment increases homocysteine levels in idiopathic hypogonadotropic hypogonadism: an indirect effect mediated by changes in body composition. J Endocrinol 179:35-39
37. Giltay E, Hoogeveen E, Elbers J, Gooren L, Asscheman H, Stehouwer C 1998 Effects of sex steroids on plasma total homocysteine levels: a study in transsexual males and females. J Clin Endocrinol Metab 83:550-553
38. Zmuda J, Bausserman L, Maceroni D, Thompson P 1997 The effect of supraphysiologic doses of testosterone on fasting total homocysteine levels in normal men. Atherosclerosis 130:199-202
39. Miller K, Corcoran C, Armstrong C, Caramelli K, Anderson E, Cotton D, Basgoz N, Hirschhorn L, Tuomala R, Schoenfeld D, Daugherty C, Mazer N, Grinspoon S 1998 Transdermal testosterone administration in women with acquired immunodeficiency syndrome wasting: a pilot study. J Clin Endocrinol Metab 83:2717-2725
40. Miller K, Grieco K, Klibanski A 2005 Testosterone administration in women with anorexia nervosa. J Clin Endocrinol Metab 90:1428-1433
41. Simon J, Braunstein G, Nachtigall L, Utian W, Katz M, Miller S, Waldbaum A, Bouchard C, Derzko C, Buch A, Rodenberg C, Lucas J, Davis S 2005 Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 90:5226-5233
42. Hickok L, Toomey C, Speroff L 1993Acomparison of esterified estrogens with and without methyltestosterone: effects on endometrial histology and serum lipoproteins in postmenopausal women. Obstet Gynecol 82:919-924
43. Wittert G, Chapman I, Haren M, Mackintosh S, Coates P, Morley J 2003 Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status. J Gerontol A Biol Sci Med Sci 58:618-625
44. Arlt W, Callies F, van Vlijmen J, Koehler I, Reincke M, Bidlingmaier M, Huebler D, Oettel M, Ernst M, Schulte H, Allolio B 1999 Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 341:1013-1020