Dexamethasone for the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases - A pilot study

Supportive Care in Cancer

Volumn 15, Issue 6, 2007, Pages 643-647

  Chow, Edward ^a,b   Loblaw, Andrew ^a   Harris, Kristin ^a   Doyle, Meagan ^a   Goh, Philiz ^a   Chiu, Hannah ^a   Panzarella, Tony ^a   Tsao, May ^a   Barnes, Elizabeth A ^a   Sinclair, Emily ^a   Farhadian, Macey ^a   Danjoux, Cyril ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

Author keywords

Bone metastases; Dexamethasone; Pain flare; Palliative radiotherapy

Indexed keywords

ANALGESIC AGENT; DEXAMETHASONE; MORPHINE;

ADJUVANT THERAPY; AGED; ARTICLE; BONE METASTASIS; BRIEF PAIN INVENTORY; CLINICAL ARTICLE; CLINICAL TRIAL; DISEASE EXACERBATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERANCE; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HUMAN; LIMB; MALE; MOOD; PAIN; PALLIATIVE THERAPY; PELVIS; PRIORITY JOURNAL; PROPHYLAXIS; RADIATION DOSE; SIDE EFFECT; SLEEP; SPINE;

AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; BONE NEOPLASMS; CHEMOTHERAPY, ADJUVANT; DEXAMETHASONE; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN; PALLIATIVE CARE; PILOT PROJECTS; RADIATION INJURIES; TREATMENT OUTCOME;

EID: 34447118989     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00520-007-0217-z     Document Type: Article

References (5)

1. Wu J, Wong R, Johnston M et al (2003) Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiation Oncology Biol Phys 55(3):594-605
2. Loblaw DA, Wu JSY, Warde P et al (2001) Pain flare after palliative radiotherapy for osseous metastases: a nested randomized controlled trial of single versus multiple fractions. Proc Amer Soc Clin Oncol 20(1):395a, (abstract 1578)
3. Kirkbride PA, Bezjak A, Pater J et al (2000) Dexamethasone for the prophylaxis for radiation-induced emesis: a National Cancer Institute of Canada Clinical Trails Group Phase III Study. J Clin Oncol 18(9):1960-1966
4. Fleming TR (1982) One-sample multiple testing procedure for Phase II clinical trials. Biometrics 38:143-151
5. Chow E, Ling A, Davis L et al (2005) Pain flare following external beam radiotherapy and meaningful change in pain scores in the treatment of bone metastases. Radiother Oncol 75:64-69