Metabolic epoxidation of an α,β-unsaturated oxime generates sensitizers of extreme potency. Are nitroso intermediates responsible?

Chemical Research in Toxicology

Volumn 20, Issue 6, 2007, Pages 927-936

  Bergström, Moa Andresen ^a   Luthman, Kristina ^a   Karlberg, Ann Therese ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYLIC CARBON; ALPHA,BETA UNSATURATED OXIME; CARBON; NITROSO DERIVATIVE; OXIME DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; EPOXIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; SKIN ALLERGY; SKIN DISEASE; SYNTHESIS;

ACETYLCYSTEINE; ALLERGENS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; FEMALE; GLUTATHIONE; HUMANS; HYDROGEN-ION CONCENTRATION; LYMPH NODES; MICE; MICE, INBRED CBA; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NITROSO COMPOUNDS; OLIGOPEPTIDES; OXIDATION-REDUCTION; OXIMES; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; TOXICITY TESTS;

ANIMALIA; MUS;

EID: 34447118901     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx7000114     Document Type: Article

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