Regulation of SNARE fusion machinery by fatty acids

Cellular and Molecular Life Sciences

Volumn 64, Issue 13, 2007, Pages 1597-1608

  Davletov, B ^a   Connell, E ^a   Darios, F ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Exocytosis; Fatty acid; Palmitoylation; Phospholipase; SNARE

Indexed keywords

FATTY ACID; HYBRID PROTEIN; LIPID; MEMBRANE PROTEIN; NEUROTRANSMITTER; PHOSPHOLIPASE; POLYUNSATURATED FATTY ACID; SNARE PROTEIN;

ALPHA HELIX; CHEMICAL ANALYSIS; GENETIC ANALYSIS; HORMONE RELEASE; MEMBRANE FUSION; MEMBRANE VESICLE; NERVE CELL DIFFERENTIATION; NONHUMAN; PALMITOYLATION; PROTEIN FUNCTION; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; FATTY ACIDS; FATTY ACIDS, UNSATURATED; HUMANS; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; PALMITIC ACID; PHOSPHOLIPASES; SNARE PROTEINS;

EID: 34447117683     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-007-6557-5     Document Type: Review

References (9)

1. Sollner, T., Bennett, M. K., Whiteheart, S. W., Scheller, R. H. and Rothman, J. E. (1993) A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation and fusion. Cell 75, 409-418.
2. Sutton, R. B., Fasshauer, D., Jahn, R. and Brunger, A. T. (1998) Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Aresolution. Nature 395, 347-353.
3. Sudhof, T. C. (2004) The synaptic vesicle cycle. Annu. Rev. Neurosci. 27, 509-547.
4. Jahn, R. and Scheller, R. H. (2006) SNAREs-engines for membrane fusion. Nat. Rev. Mol. Cell Biol. 7, 631-643.
5. Rizo, J. and Sudhof, T. C. (2002) Snares and Munc18 in synaptic vesicle fusion. Nat. Rev. Neurosci. 3, 641-653.
6. Li, L. and Chin, L. S. (2003) The molecular machinery of synaptic vesicle exocytosis. Cell. Mol. Life Sci. 60, 942-960.
7. Rohrbough, J. and Broadie, K. (2005) Lipid regulation of the synaptic vesicle cycle. Nat. Rev. Neurosci. 6, 139-150.
8. Huang, F. D., Woodruff, E., Mohrmann, R. and Broadie, K. (2006) Rolling blackout is required for synaptic vesicle exocytosis. J. Neurosci. 26, 2369-2379.
9. Vijayakrishnan, N. and Broadie, K. (2006) Temperature-sensitive paralytic mutants: insights into the synaptic vesicle cycle. Biochem. Soc. Trans. 34, 81-87.