Disruption of the aspartate to heme ester linkage in human myeloperoxidase: Impact on ligand binding, redox chemistry, and interconversion of redox intermediates

Journal of Biological Chemistry

Volumn 282, Issue 23, 2007, Pages 17041-17052

  Zederbauer, Martina ^a   Furtmüller, Paul G ^a   Bellei, Marzia ^b   Stampler, Johanna ^a   Jakopitsch, Christa ^a   Battistuzzi, Gianantonio ^b   Moguilevsky, Nicole ^c   Obinger, Christian ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIMOLECULAR RATES; LIGAND BINDING; MONOMERIC RECOMBINANT MYELOPEROXIDASE (MPO); TYROSINE;

AMINO ACIDS; ESTERS; IRON; LIGANDS; MONOMERS; REDOX REACTIONS;

ENZYME ACTIVITY;

ASCORBIC ACID; ASPARTIC ACID; BROMIDE; CHLORIDE; ENZYME VARIANT; ESTER; HEME; IODIDE; LIGAND; MONOMER; MYELOPEROXIDASE; RECOMBINANT ENZYME; THIOCYANATE; TYROSINE; PEROXIDASE;

ARTICLE; BIOCHEMISTRY; BIOPHYSICS; CATALYSIS; CHEMICAL BOND; CHO CELL; COVALENT BOND; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; OXIDATION REDUCTION REACTION; PH; PRIORITY JOURNAL; REDUCTION; WILD TYPE; ANIMAL; CHEMISTRY; CRICETULUS; ELECTROCHEMISTRY; HAMSTER; HUMAN; KINETICS; METABOLISM; METHODOLOGY; PROTEIN BINDING; SPECTROSCOPY;

CRICETULUS GRISEUS;

ANIMALS; ASPARTIC ACID; CHO CELLS; CRICETINAE; CRICETULUS; ELECTROCHEMISTRY; ESTERS; HEME; HUMANS; KINETICS; LIGANDS; OXIDATION-REDUCTION; PEROXIDASE; PROTEIN BINDING; SPECTRUM ANALYSIS;

EID: 34447117575     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610685200     Document Type: Article

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