Cholinergic activation of phasic activity in the isolated bladder: Possible evidence for M3- and M2-dependent components of a motor/sensory system

BJU International

Volumn 100, Issue 3, 2007, Pages 668-678

  Finney, Steven M ^a   Stewart, Laurence H ^a   Gillespie, James I ^b  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

4 DAMP; AFDX 116; Darifenacin; Phasic activity

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ARECAIDINE; CARBACHOL; DARIFENACIN; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; OTENZEPAD;

ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; BLADDER PRESSURE; CANNULATION; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GUINEA PIG; MOTOR SYSTEM; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSORY SYSTEM; STEADY STATE; TEMPERATURE DEPENDENCE;

ANIMALS; ARECOLINE; BENZOFURANS; CARBACHOL; CHOLINERGIC AGONISTS; FEMALE; GUINEA PIGS; MUSCARINIC AGONISTS; PIPERIDINES; PYRROLIDINES; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; URINARY BLADDER; URINATION;

EID: 34447115503     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2007.07021.x     Document Type: Article

References (41)

1. Abrams P, Cardozo L, Fall M et al. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-Committee of the International Continence Society. Neurourol Urodyn 2002 21 : 167 78
2. Milsom I, Abrams P, Cardozo L, Roberts RG, Thuroff J, Wein AJ. How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int 2001 87 : 760 6
3. Stewart WF, Herzog A, Wein A et al. Prevalence and impact of overactive bladder in the US: results from the NOBLE program. Neurol Urodyn 2001 20 : 406 8
4. Hashim H, Abrams P. Do symptoms of overactive bladder predict urodynamics detrusor overactivity? Neurourol Urodyn 2004 23 : 484 6
5. Andersson KE, Wein AJ. Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 2004 56 : 581 631
6. Andersson KE, Yoshida M. Antimuscarinics and the overactive detrusor - which is the main mechanism of action? Eur Urol 2003 43 : 1 5
7. Finney SM, Andersson KE, Gillespie JI, Stewart LH. Antimuscarinic drugs in detrusor overactivity and the overactive bladder (OAB) syndrome: motor or sensory actions? BJU Int 2006 98 : 503 7
8. Andersson KE. Bladder activation: afferent mechanisms. Urology 2002 59 (Suppl. 1 43 50
9. Kim Y, Yoshimura N, Masuda H, de Miguel F, Chancellor MB. Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder afferent pathways. Urology 2005 65 : 238 42
10. Yokoyama O, Yusup A, Miwa Y, Oyama N, Aoki Y, Akino H. Effects of tolterodine on an overactive bladder depends on suppression of C-fiber bladder afferent activity in rats. J Urol 2005 174 : 2032 6
11. Drake MJ, Harvey IJ, Gillespie JI. Autonomous activity in the isolated guinea pig bladder. Exp Physiol 2003 88 : 19 30
12. Gillespie JI, Harvey IJ, Drake MJ. Agonist and nerve-induced phasic activity in the isolated whole bladder of the guinea pig: evidence for two types bladder activity. Exp Physiol 2003 88 : 343 57
13. Gillespie JI. The autonomous bladder: a view of the origin of bladder overactivity and sensory urge. BJU Int 2004 93 : 478 83
14. Gillespie JI. A developing view of the origins of urgency: the importance of animal models. BJU Int 2005 96 (Suppl. 1 22 8
15. Kashihara K, Varga EV, Waite SL, Roeske WR, Yamamura HI. Cloning of the rat M3. M4 and M5 muscarinic acetylcholine receptor genes by the polymerase chian reaction (PCR) and pharmacological characterization of the expressed genes. Life Sci 1992 51 : 955 71
16. Andersson KE, Arner A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 2004 84 : 935 86
17. Yamanishi T, Chapple CR, Chess-Williams R. Which muscarinic receptor is important in the bladder? World J Urol 2001 19 : 299 306
18. Yamanishi T, Chapple CR, Yasuda K, Chess-Williams R. The role of M2 muscarinic receptor subtypes in mediating contraction of the pig bladder base after cyclic adenosine monophosphate elevation and/or selective M3 inactivation. J Urol 2002 167 : 397 401
19. Hegde SS, Choppin A, Bonhaus D et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol 1997 120 : 1409 18
20. Braverman AS, Karlovsky M, Pontari MA, Ruggieri MR. Aging and hypertrophy change the muscarinic receptor sub-type mediating contraction from M3 to M2. J Urol 2002 167 : 43 (abstract 170)
21. Chess-Williams R. Potential therapeutic targets for the treatment of detrusor overactivity. Expert Opin Ther Targets 2004 8 : 95 106
22. Barlow RB, Shepherd MK. A further search for selectve antagonists at M2-muscarinic receptors. Br J Pharmacol 1986 89 : 837 43
23. Mosso MA, Pellacani P. Sur le fonctions de la vessie. Arch Ital Biol 1882 1 : 291 324
24. Sherrington CS. Notes on the arrangement of some motor fibres in the lumbo-sacral plexus. J Physiol 1892 13 : 621 772
25. Vaughan CW, Satchell PM. Urine storage mechanisms. Prog Neurobiol 1995 46 : 215 37
26. Streng T, Hedlund P, Talo A, Andersson KE, Gillespie JI. Phasic non-micturition contractions in the bladder of the anaesthetized and awake rat. BJU Int 2006 97 : 1094 101
27. Starling EH. Elements of Human Physiology, 7th edn. London : Churchill, 1905
28. Gillespie JI. Modulation of autonomous contractile activity in the isolated bladder of the guinea pig. BJU Int 2004 93 : 393 400
29. Gillespie JI. Inhibitory actions of calcitonin gene-related peptide and capsaicin: evidence for local axonal reflexes in the bladder wall. BJU Int 2005 95 : 149 56
30. Gillespie JI. Noradrenaline inhibits autonomous activity in the isolated guinea pig bladder. BJU Int 2004 93 : 401 9
31. Hammer R, Giraldo E, Schiavi GB, Monferini E, Ladinski H. Binding profile of a novel cardioselective muscarinic receptor antagonist AF-DX 116, to membranes of peripheral tissues and brain in the rat. Life Sci 1986 38 : 1653 62
32. Barlow RB, Weston-Smith P. The relative potencies of some agonists at M2 muscarinic receptors in guinea-pig ileum, atria and bronchi. Br J Pharmacol 1985 85 : 437 40
33. Gillespie JI. Phosphodiesterase-linked inhibition of nonmicturition activity in the isolated bladder. BJU Int 2004 93 : 1325 32
34. Smet PJ, Jonavicius J, Marshall VR, de Vente J. Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience 1996 71 : 337 48
35. McCloskey KD, Gurney AM. Kit positive cells in the guinea pig bladder. J Urol 2002 168 : 832 6
36. Hashitani H, Yanai Y, Suzuki H. Role of interstitial cells and gap junctions in the transmission of spontaneous Ca2+ signals in detrusor smooth muscles of the guinea-pig urinary bladder. J Physiol 2004 559 : 567 81
37. Gillespie JI, Markerink-van Ittersum M, de Vente J. cGMP-generating cells in the bladder wall: identification of distinct networks of interstitial cells. BJU Int 2004 94 : 1114 24
38. Davidson RA, McCloskey KD. Morphology and localization of interstitial cells in the guinea pig bladder: structural relationships with smooth muscle and neurons. J Urol 2005 173 : 1385 90
39. Gillespie JI, Markerink-van Ittersum M, de Vente J. Interstitial cells and cholinergic signalling in the outer muscle layers of the guinea-pig bladder. BJU Int 2006 97 : 379 85
40. Lagou M, Drake MJ, Markerink-van Ittersum M, de Vente J, Gillespie JI. Interstitial cells and phasic activity in the isolated mouse bladder. BJU Int 2006 98 : 643 50
41. Gillespie JI, Markerink-van Ittersum M, de Vente J. Sensory collaterals, intramural ganglia and motor nerves in the guinea-pig bladder: evidence for intramural neural circuits. Cell Tissue Res 2006 325 : 33 45