A random model for mapping imprinted quantitative trait loci in a structured pedigree: An implication for mapping canine hip dysplasia

Genomics

Volumn 90, Issue 2, 2007, Pages 276-284

  Liu, Tian ^a   Todhunter, Rory J ^b   Wu, Song ^a   Hou, Wei ^c   Mateescu, Raluca ^b   Zhang, Zhiwu ^b   Burton Wurster, Nancy I ^b   Acland, Gregory M ^b   Lust, George ^b   Wu, Rongling ^a  

^a University of Florida ^*  (United States)

^b Department of Obstetrics Gynecology   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Canine hip dysplasia; Imprinting quantitative trait loci; Parent of origin effect; Random effect model

Indexed keywords

ALLELE; ARTICLE; CONTROLLED STUDY; DOG DISEASE; GENE FUNCTION; GENE MAPPING; GENE STRUCTURE; GENETIC VARIABILITY; GENOME IMPRINTING; MAXIMUM LIKELIHOOD METHOD; NONHUMAN; OSSIFICATION; PEDIGREE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RANDOMIZATION;

ANIMALS; DOGS; GENOMIC IMPRINTING; HIP DYSPLASIA, CANINE; LINKAGE (GENETICS); MODELS, STATISTICAL; PEDIGREE; QUANTITATIVE TRAIT LOCI;

ANIMALIA;

EID: 34447107674     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2007.04.004     Document Type: Article

References (39)

1. Barlow D.P. Gametic imprinting in mammals. Science 270 (1995) 1610-1613
2. Reik W., and Walter J. Genomic imprinting: parental influence on the genome. Nat. Rev. Genet. 2 (2001) 21-32
3. Reik W., and Walter J. Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote. Nat. Genet. 27 (2001) 255-256
4. Luedi P.P., et al. Genome-wide prediction of imprinted murine genes. Genome Res. 15 (2005) 875-884
5. Nezer C., et al. An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nat. Genet. 21 (1999) 155-156
6. Jeon J.T., et al. A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nat. Genet. 21 (1999) 157-158
7. Vacik T., and Forejt J. Quantification of expression and methylation of the Igf2r imprinted gene in a segmental trisomic mouse model. Genomics 82 (2003) 261-268
8. Sado T., and Ferguson-Smith A.C. Imprinted X inactivation and reprogramming in the preimplantation mouse embryo. Hum. Mol. Genet. 14 (2005) R59-R64 (Suppl.)
9. Knott S.A., et al. Multiple marker mapping of quantitative trait loci in a cross between outbred wild boar and large white pigs. Genetics 149 (1998) 1069-1080
10. de Koning D.-J., et al. On the detection of imprinted quantitative trait loci in experimental crosses of outbred species. Genetics 161 (2002) 931-938
11. de Koning D.-J., et al. Genome-wide scan for body composition in pigs reveals important role of imprinting. Proc. Natl. Acad. Sci. USA 97 (2000) 7947-7950
12. Tuiskula-Haavisto M., et al. Quantitative trait loci with parent-of-origin effects in chicken. Genet. Res. 84 (2004) 57-66
13. 2 design. Genomics 87 (2006) 543-551
14. Xu S.Z., and Atchley W.A. A random model approach to interval mapping of quantitative trait loci. Genetics 141 (1995) 1189-1197
15. Hanson R.L., et al. Assessment of parent-of-origin effects in linkage analysis of quantitative traits. Am. J. Hum. Genet. 68 (2001) 951-962
16. Shete S., and Amos C.I. Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting. Am. J. Hum. Genet. 70 (2002) 751-757
17. Haghighi F., and Hodge S.E. Likelihood formulation of parent-of-origin effects on segregation analysis, including ascertainment. Am. J. Hum. Genet. 70 (2002) 142-156
18. Shete S., et al. Genomic imprinting and linkage test for quantitative trait loci in extended pedigrees. Am. J. Hum. Genet. 73 (2003) 933-938
19. Bliss S., et al. Quantitative genetics of traits associated with hip dysplasia in a canine pedigreecontructed by mating dysplastic Labrador retrievers with unaffected greyhounds. Am. J. Vet. Res. (2002) 1029-1035
20. Todhunter R.J., et al. Quantitative trait loci for hip dysplasia in a crossbreed canine pedigree. Mamm. Genome 16 (2005) 720-730
21. Breen M., et al. Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radation-hybrid/linkage map of the domestic dog genome to all chromosomes. Mamm. Genome 11 (2001) 1784-1795
22. Todhunter R.J., et al. Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedgree. J. Hered. 94 (2003) 39-48
23. Chase K., et al. Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxty in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris). Am. J. med. Genet. 124A (2004) 239-247
24. Lin M., et al. A general statistical framework for mapping quantitative trat loc in non-model systems: issue for characterizing linkage phases. Genetics 165 (2003) 901-913
25. Heuven H.C.M., et al. Efficiency of population structures for mapping of Mendelian ang imprinted quantitative trat loci in outbred pigs using variance componenet methods. Genet. Sel. Evol. 37 (2005) 635-655
26. Wu C.-T., and Morris J.R. Genes, genetics, and epigenetics: a correspondence. Science 293 (2001) 1103-1105
27. Feinberg A.P., et al. The epigenetic progenitor origin of human cancer. Nat. Rev. Genet. 7 (2006) 21-23
28. Chase K., et al. Genetic regulation of osteoarthritis: a QTL regulating cranial and caudal acetabular osteophyte formation in the hip joint of the dog (Canis familiaris). Am. J. Med. Genet. 135A (2005) 334-335
29. Chase K., et al. Genetics basis for systems of skeletal quantitative traits: principal componenet analysis of the canid skeleton. Proc. Natl. Acad. Sci. USA 99 (2002) 9930-9935
30. Parker H.G., and Ostrander E.A. Canine genomics and genetics: running with the pack. PloS Genet. 1 5 (2005) e58
31. Character C., et al. The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status. Nat. Genet. 27 (2001) 367-369
32. Raefski A.S., and O'Neill M.J. Identification of a cluster of X-linked imprinted genes in mice. Nat. Genet. 37 (2005) 620-624
33. Pfeifer K. Mechanisms of genomic imprinting. Am. J. Hum. Genet. 67 (2000) 777-787
34. Caspary T., et al. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol. Cell Biol. 18 (1998) 3466-3474
35. Lou X.Y., et al. The extent and distribution of linkage disequilibrium in canine. Mamm. Genome 14 (2003) 555-564
36. Sutter N.B., and Ostrander E.A. Dog star rising: the canine genetic system. Nat. Rev. Genet. 5 (2004) 900-910
37. Liu T., et al. Extent and distribution of zygotic linkage disequilibrium in a canine multigenerational pedigree. Genetics 174 (2006) 439-453
38. Mellersh C.S., et al. An integrated linkage-radation hybrid map of the canine genome. Mamm. Genome 11 (2000) 120-130
39. Fulker D.W., and Cardon L.R. A sib-pair approach to interval mapping of quantitative trait loci. Am. J. Hum. Genet. 54 (1994) 1092-1103