Styrene-oxide N-terminal valine haemoglobin adducts in reinforced plastic workers: Possible influence of genetic polymorphism of drug-metabolising enzymes

Toxicology

Volumn 237, Issue 1-3, 2007, Pages 58-64

  Teixeira, J P ^a   Gaspar, J ^b   Roma Torres, J ^a   Silva, S ^a   Costa, C ^a   Roach, J ^c   Mayan, O ^a   Rueff, J ^b   Farmer, P B ^c  

^a NATIONAL INSTITUTE OF HEALTH   (Portugal)

^b NOVA MEDICAL SCHOOL   (Portugal)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Biological monitoring; Genetic polymorphisms; Haemoglobin adducts; Occupational exposure; Styrene

Indexed keywords

CREATININE; DRUG METABOLIZING ENZYME; GLOBIN; HEMOGLOBIN; PLASTIC; STYRENE; STYRENE OXIDE; VALINE;

ADULT; AIR POLLUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BIOLOGICAL MONITORING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; DATA ANALYSIS; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; FEMALE; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALE; MAXIMUM ALLOWABLE CONCENTRATION; METABOLITE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; URINALYSIS;

ADULT; AIR POLLUTANTS, OCCUPATIONAL; BIOLOGICAL MARKERS; CHEMICAL INDUSTRY; ENZYMES; EPOXY COMPOUNDS; FEMALE; GLYOXYLATES; HEMOGLOBINS; HUMANS; MALE; MANDELIC ACIDS; METABOLIC DETOXICATION, DRUG; OCCUPATIONAL EXPOSURE; POLYMORPHISM, GENETIC; STYRENE; VALINE; WORKPLACE;

EID: 34447104036     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.04.019     Document Type: Article

References (26)

1. ACGIH, American Conference of the Governmental Industrial Hygienists (2003). Styrene, monomer in ACGIH documentation of the threshold limit values and biological exposure indices. Science Group ACGIH, Cincinnati, OH.
2. Apostoli P., Brugnone F., Perbellini L., Cocheo V., Bellomo M.L., and Silvestri R. Occupational styrene exposure: environmental and biological monitoring. Am. J. Ind. Med. 4 (1983) 741-754
3. Brenner D.D., Jeffrey A.M., Latriano L., Wazneh L., Warburton D., Toor M., Pero R.W., Andrews L.R., Walles S., and Perera F.P. Biomarkers in styrene-exposed boatbuilders. Mutat. Res. 261 (1991) 225-236
4. Christakopoulos A., Bergmark E., Zorcec V., Norppa H., Maki-Paakkanen J., and Osterman-Golkar S. Monitoring occupational exposure to styrene from haemoglobin adducts and metabolites in blood. Scand. J. Work Environ. Health 19 (1993) 255-263
5. De Palma G., Manini P., Mozzoni P., Andreoli R., Bergamaschi E., Cavazzini S., Franchini I., and Mutti A. Polymorphism of xenobiotic-metabolizing enzymes and excretion of styrene-specific mercapturic acids. Chem. Res. Toxicol. 14 (2001) 1393-1400
6. Farmer P.B., Bailey E., Naylor S., Anderson D., Brooks A., Cushnir J., Lamb J.H., Sepai O., and Tang Y. Identification of endogenous electrophiles by means of mass spectrometric determination of protein and DNA adducts. Environ. Health Perspect. 99 (1993) 19-24
7. Fustinoni S., Colosio C., Colombi A., Lastrucci L., Yeowell-O'Connell K., and Rappaport S.M. Albumin and haemoglobin adducts as biomarkers of exposure to styrene in fibreglass-reinforced plastics workers. Int. Arch. Occup. Environ. Health 71 (1998) 35-41
8. Hallier E., Goergens H.W., Karels H., and Golka K. A note on individual differences in the urinary excretion of optical enantiomers of styrene metabolites and of styrene-derived mercapturic acids in humans. Arch. Toxicol. 69 (1995) 300-305
9. Haufroid V., Buchet J.P., Gardinal S., Ghittori S., Imbriani M., Hirvonen A., and Lison D. Importance of genetic polymorphisms of drug-metabolizing enzymes for the interpretation of biomarkers of exposure to styrene. Biomarkers 6 (2001) 236-249
10. International Agency for Research on Cancer (IARC). Some Industrial Chemicals. IARC Monographs on the Evaluation of the Carcinogenic Risk to Humans vol. 60 (1994), IARC, Lyon
11. Johanson G., Ernstgard L., Gullstrand E., Lof A., Osterman-Golkar S., Williams C.C., and Sumner S.C.J. Styrene oxide in blood, haemoglobin adducts and urinary metabolites in human volunteers exposed to C-13(8) styrene vapours. Toxicol. Appl. Phrmacol. 168 (2000) 36-49
12. Kivisto H., Pekari K., and Aitio A. Analysis and stability of phenylglyoxylic and mandelic acids in the urine of styrene-exposed people. Int. Arch. Occup. Environ. Health 64 (1993) 399-403
13. Migliore L., Naccarati A., Coppede F., Bergamaschi E., De Palma G., Voho A., Manini P., Jarventaus H., Mutti A., Norppa H., and Hirvonen A. Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene. Pharmacogenet. Genom. 16 (2006) 87-99
14. Miller R.R., Newhook R., and Poole A. Styrene production, use and human exposure. Crit. Rev. Toxicol. 24 Suppl. (1994) S1-S10
15. Nakajima T., Elovaara E., Gonzalez F.J., Gelboin H.V., Raunio H., Pelkonen O., Vainio H., and Aoyama T. Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chem. Res. Toxicol. 7 (1994) 891-896
16. NIOSH, Manual of Analytical Methods (1994). Cincinnati, Ohio.
17. Rappaport S.M., and Yeowell-O'Connell K. Protein adducts as dosimeters of human exposure to styrene, styrene-7,8-oxide, and benzene. Toxicol. Lett. 108 (1999) 117-126
18. Rappaport S.M., Yeowell-O'Connell K., Bodell W., Yager J.W., and Symanski E. An investigation of cancer biomarkers among workers exposed to styrene and styrene-7,8-oxide. Cancer Res. 56 (1996) 5410-5416
19. Sarmanova J., Tynkova L., Susova S., Gut I., and Soucek P. Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic. Pharmacogenetics 10 (2000) 781-788
20. Sumner S.J., and Fennell T.R. Review of the metabolic fate of styrene. Crit. Rev. Toxicol. 24 Suppl. (1994) S11-S33
21. Tavares R., Borba H., Monteiro M., Proenca M.J., Lynce N., Rueff J., BaUey E., Sweetman G.M.A., Lawrence R.M., and Farmer P.B. Monitoring of exposure to acrylonitrile by determination of N-(2-cyanoethyl)valine at the N-terminal position of haemoglobin. Carcinogenesis 12 (1996) 2655-2660
22. Teixeira J.P., Gaspar J., Silva S., Torres J., Silva S.N., Azevedo M.C., Neves P., Laffon B., Mendez J., Goncalves C., Mayan O., Farmer P.B., and Rueff J. Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1. Toxicology 195 (2004) 231-242
23. Van Welie R.T.H., Van Dick R.G.J., Vermeulen N.P.E., and Van Sittert N.J. Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals. Crit. Rev. Toxicol. 22 (1992) 271-306
24. Vodicka P., Tvrdik T., Osterman-Golkar S., Vodickova L., Peterkova K., Soucek P., Sarmanova J., Farmer P.B., Granath F., Lambert B., and Hemminki K. An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers. Mutat. Res. 445 (1999) 205-224
25. Wenker M.A., Kezic S., Monster A.C., and de Wolff F.A. Metabolic capacity and interindividual variation in toxicokinetics of styrene in volunteers. Hum. Exp. Toxicol. 20 (2001) 221-228
26. Yeowell-O'Connell K., Jin Z., and Rappaport S.M. Determination of albumin and hemoglobin adducts in workers exposed to styrene and styrene oxide. Cancer Epidemiol. Biomarkers Prev. 5 (1996) 205-215