Ultrastructure of oval cells in children with chronic hepatitis B, with special emphasis on the stage of liver fibrosis: The first pediatric study

World Journal of Gastroenterology

Volumn 13, Issue 21, 2007, Pages 2918-2922

  Sobaniec Lotowska, Maria Elzbieta ^a   Lotowska, Joanna Maria ^a   Lebensztejn, Dariusz Marek ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Chronic hepatitis B; Fibrosis; Liver biopsy; Oval cells; Pediatric patients; Ultrastructural study

Indexed keywords

GLUTARALDEHYDE; PARAFORMALDEHYDE;

ADOLESCENT; ARTICLE; CELL DIFFERENTIATION; CELL ULTRASTRUCTURE; CHILD; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEPATITIS B; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER BIOPSY; LIVER CELL; LIVER FIBROSIS; MALE; MORPHOGENESIS; PROGNOSIS; SCORING SYSTEM; STEM CELL; TRANSMISSION ELECTRON MICROSCOPY; VIRUS CLASSIFICATION;

EID: 34447102611     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i21.2918     Document Type: Article

References (32)

1. Bustos M, Sangro B, Alzuguren P, Gil AG, Ruiz J, Beraza N, Qian C, Garcia-Pardo A, Prieto J. Liver damage using suicide genes. A model for oval cell activation. Am J Pathol 2000; 157: 549-559
2. He ZP, Tan WQ, Tang YF, Zhang HJ, Feng MF. Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers. Cell Prolif 2004; 37: 177-187
3. Kofman AV, Morgan G, Kirschenbaum A, Osbeck J, Hussain M, Swenson S, Theise ND. Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury. Hepatology 2005; 41: 1252-1261
4. Matsusaka S, Toyosaka A, Nakasho K, Tsujimura T, Sugihara A, Takanashi T, Uematsu K, Terada N, Okamoto E. The role of oval cells in rat hepatocyte transplantation. Transplantation 2000; 70: 441-446
5. Menthena A, Deb N, Oertel M, Grozdanov PN, Sandhu J, Shah S, Guha C, Shafritz DA, Dabeva MD. Bone marrow progenitors are not the source of expanding oval cells in injured liver. Stem Cells 2004; 22: 1049-1061
6. Yoon BI, Choi YK, Kim DY. Differentiation processes of oval cells into hepatocytes: proposals based on morphological and phenotypical traits in carcinogen-treated hamster liver. J Comp Pathol 2004; 131: 1-9
7. Fotiadu A, Tzioufa V, Vrettou E, Koufogiannis D, Papadimitriou CS, Hytiroglou P. Progenitor cell activation in chronic viralhepatitis. Liver Int 2004; 24: 268-274
8. Parent R, Marion MJ, Furio L, Trepo C, Petit MA. Origin and characterization of a human bipotent liver progenitor cell line. Gastroenterology 2004; 126: 1147-1156
9. Uenishi T, Hirohashi K, Shuto T, Tsukamoto T, Yamamoto T, Ogawa M, Kubo S, Tanaka H, Kinoshita H. Primary liver cancer with dual expression of hepatocyte and bile duct epithelial markers. Hepatogastroenterology 2002; 49: 1092-1094
10. Xiao JC, Ruck P, Adam A, Wang TX, Kaiserling E. Small epithelial cells in human liver cirrhosis exhibit features of hepatic stem-like cells: immunohistochemical, electron microscopic and immunoelectron microscopic findings. Histopathology 2003; 42: 141-149
11. Xiao JC, Jin XL, Ruck P, Adam A, Kaiserling E. Hepatic progenitor cells in human liver cirrhosis: immunohistochemical, electron microscopic and immunofluorencence confocal microscopic findings. World J Gastroenterol 2004; 10: 1208-1211
12. Guettier C. Which stem cells for adult liver? Ann Pathol 2005; 25: 33-44
13. Novikoff PM, Yam A, Oikawa I. Blast-like cell compartment in carcinogen-induced proliferating bile ductules. Am J Pathol 1996; 148: 1473-1492
14. Sell S. Electron microscopic identification of putative liver stem cells and intermediate hepatocytes following periportal necrosis induced in rats by allyl alcohol. Stem Cells 1997; 15: 378-385
15. Vessey CJ, de la Hall PM. Hepatic stem cells: a review. Pathology 2001; 33: 130-141
16. Housset C. Biliary epithelium, hepatocytes and oval cells. Rev Prat 2000; 50: 2106-2111
17. Grompe M. The role of bone marrow stem cells in liver regeneration. Semin Liver Dis 2003; 23: 363-372
18. Brooling JT, Campbell JS, Mitchell C, Yeoh GC, Fausto N. Differential regulation of rodent hepatocyte and oval cell proliferation by interferon gamma. Hepatology 2005; 41: 906-915
19. Schaff Z, Nagy P. Novel factors playing a role in the pathomechanism of diffuse liver diseases: apoptosis and hepatic stem cells. Orv Hetil 2004; 145: 1787-1793
20. Sun C, Jin XL, Xiao JC. Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study. Histopathology 2006; 48: 546-555
21. Tan J, Hytiroglou P, Wieczorek R, Park YN, Thung SN, Arias B, Theise ND. Immunohistochemical evidence for hepatic progenitor cells in liver diseases. Liver 2002; 22: 365-373
22. Roskams T, De Vos R, Van Eyken P, Myazaki H, Van Damme B, Desmet V. Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man. J Hepatol 1998; 29: 455-463
23. Lebensztejn DM, Sobaniec-Lotowska M, Kaczmarski M, Werpachowska I, Sienkiewicz J. Serum concentration of transforming growth factor (TGF)-beta 1 does not predict advanced liver fibrosis in children with chronic hepatitis B. Hepatogastroenterology 2004; 51: 229-233
24. Lebensztejn DM, Sobaniec-Lotowska ME, Bauer M, Kaczmarski M, Voelker M, Schuppan D. Serum fibrosis markers as predictors of an antifibrotic effect of interferon alfa in children with chronic hepatitis B. Eur J Gastroenterol Hepatol 2005; 17: 843-848
25. Lebensztejn DM, Sobaniec-Lotowska ME, Kaczmarski M, Voelker M, Schuppan D. Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha. World J Gastroenterol 2006; 12: 3338-3343
26. Maria Elzbieta SL, Marek LD. Histological outcome of chronic hepatitis B in children treated with interferon alpha; World J Gastroenterol 2005; 11: 7179-7182
27. Ishak K, Baptists A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween RN. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-699
28. Martinez-Hernandez A, Amenta PS. The extracellular matrix in hepatic regeneration. FASEB J 1995; 9: 1401-1410
29. Sub H, Song MJ, Park YN. Behavior of isolated rat oval cells in porous collagen scaffold. Tissue Eng 2003; 9: 411-420
30. Friedman SL. Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 2004; 1: 98-105
31. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology 2006; 43: S45-S53
32. Michalopoulos GK, DeFrances M. Liver regeneration. Adv Biochem Eng Biotechnol 2005; 93: 101-134