A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor

Carcinogenesis

Volumn 28, Issue 5, 2007, Pages 1052-1057

  Sienkiewicz, Pawel ^b   Ciolino, Henry P ^b   Leslie, Benjamin J ^a   Hergenrother, Paul J ^a   Singletary, Keith ^a   Yeh, Grace Chao ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 (3 METHOXYPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; ACRYLAMIDE DERIVATIVE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; DIMETHYLBENZ[A]ANTHRACENE; HETEROGENEOUS NUCLEAR RNA; ISODON EXCISUS EXTRACT; MESSENGER RNA; PLANT EXTRACT; UNCLASSIFIED DRUG; 3-(3-METHOXYPHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)ACRYLAMIDE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTINEOPLASTIC AGENT; CYTOCHROME P 450 CYP1B1; CYTOCHROME P-450 CYP1B1; UNSPECIFIC MONOOXYGENASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEPG2; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION REGULATION; UPREGULATION; CELL CULTURE; CHEMISTRY; DRUG EFFECT; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GENETICS; ISODON; MEDICINAL PLANT; METABOLISM; PLANT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ACRYLAMIDES; ANTICARCINOGENIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISODON; PLANT COMPONENTS; PLANTS, MEDICINAL; RECEPTORS, ARYL HYDROCARBON; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 34447099776     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgl248     Document Type: Article

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