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Volumn 76, Issue 2, 2004, Pages 484-490

Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression

Author keywords

Hematopoiesis; Hematopoietic stem cell; Interleukin 4; Knockout mouse

Indexed keywords

CYTOKINE; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR ALPHA; ONCOSTATIN M; STAT6 PROTEIN; UNCLASSIFIED DRUG;

EID: 3442882153     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0903440     Document Type: Conference Paper
Times cited : (16)

References (43)
  • 2
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin, J. E., Hackenmiller, R., Simon, M. C., Levy, D. E. (1996) Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84, 443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 3
    • 0034515268 scopus 로고    scopus 로고
    • Immune response in Stat2 knockout mice
    • Park, C., Li, S., Cha, E., Schindler, C. (2000) Immune response in Stat2 knockout mice. Immunity 13, 795-804.
    • (2000) Immunity , vol.13 , pp. 795-804
    • Park, C.1    Li, S.2    Cha, E.3    Schindler, C.4
  • 4
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan, M. H., Sun, Y. L., Hoey, T., Grusby, M. J. (1996) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 7
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan, M. H., Schindler, U., Smiley, S. T., Grusby, M. J. (1996) Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4, 313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 8
    • 0032934156 scopus 로고    scopus 로고
    • Functional roles of STAT family proteins: Lessons from knockout mice
    • Akira, S. (1999) Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 17, 138-146.
    • (1999) Stem Cells , vol.17 , pp. 138-146
    • Akira, S.1
  • 9
    • 0036899655 scopus 로고    scopus 로고
    • The Jak/STAT pathway in model organisms: Emerging roles in cell movement
    • Hou, S. X., Zheng, Z., Chen, X., Perrimon, N. (2002) The Jak/STAT pathway in model organisms: emerging roles in cell movement. Dev. Cell 3, 765-778.
    • (2002) Dev. Cell , vol.3 , pp. 765-778
    • Hou, S.X.1    Zheng, Z.2    Chen, X.3    Perrimon, N.4
  • 10
    • 0035877106 scopus 로고    scopus 로고
    • Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion
    • Zhu, J., Guo, L., Watson, C. J., Hu-Li, J., Paul, W. E. (2001) Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion. J. Immunol. 166, 7276-7281.
    • (2001) J. Immunol. , vol.166 , pp. 7276-7281
    • Zhu, J.1    Guo, L.2    Watson, C.J.3    Hu-Li, J.4    Paul, W.E.5
  • 11
    • 0036133110 scopus 로고    scopus 로고
    • Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis
    • Wurster, A. L., Withers, D. J., Uchida, T., White, M. F., Grusby, M. J. (2002) Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol. Cell. Biol. 22, 117-126.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 117-126
    • Wurster, A.L.1    Withers, D.J.2    Uchida, T.3    White, M.F.4    Grusby, M.J.5
  • 12
    • 0027931577 scopus 로고
    • Interleukin-4-a dual regulatory factor in hematopoiesis
    • Sonoda, Y. (1994) Interleukin-4-a dual regulatory factor in hematopoiesis. Leuk. Lymphoma 14, 231-240.
    • (1994) Leuk. Lymphoma , vol.14 , pp. 231-240
    • Sonoda, Y.1
  • 13
    • 0025866349 scopus 로고
    • Effects of interleukin 4 on stromal cell-associated bone marrow culture
    • Ogo, T., Otsuka, T., Satoh, H., Chifu, Y., Nakano, T., Niho, Y. (1991) Effects of interleukin 4 on stromal cell-associated bone marrow culture. Exp. Hematol. 19, 899-904.
    • (1991) Exp. Hematol. , vol.19 , pp. 899-904
    • Ogo, T.1    Otsuka, T.2    Satoh, H.3    Chifu, Y.4    Nakano, T.5    Niho, Y.6
  • 14
    • 0029046482 scopus 로고
    • Inhibition of GM-CSF production by recombinant human interleukin-4: Negative regulator of hematopoiesis
    • Sawada, K., Sato, N., Koike, T. (1995) Inhibition of GM-CSF production by recombinant human interleukin-4: negative regulator of hematopoiesis. Leuk. Lymphoma 19, 33-42.
    • (1995) Leuk. Lymphoma , vol.19 , pp. 33-42
    • Sawada, K.1    Sato, N.2    Koike, T.3
  • 15
    • 0027965542 scopus 로고
    • Human interleukin-4 enhances stromal cell-dependent hematopoiesis: Costimulation with stem cell factor
    • Keller, U., Aman, M. J., Derigs, G., Huber, C., Peschel, C. (1994) Human interleukin-4 enhances stromal cell-dependent hematopoiesis: costimulation with stem cell factor. Blood 84, 2189-2196.
    • (1994) Blood , vol.84 , pp. 2189-2196
    • Keller, U.1    Aman, M.J.2    Derigs, G.3    Huber, C.4    Peschel, C.5
  • 16
    • 0027893086 scopus 로고
    • Effects of interleukin-4 on myelopoiesis: Localization of the action of IL-4 in the CD34+HLA-DR+ + subset and distinction between direct and indirect effects of IL-4
    • Snoeck, H. W., Lardon, F., Van Bockstaele, D. R., Peetermans, M. E. (1993) Effects of interleukin-4 on myelopoiesis: localization of the action of IL-4 in the CD34+HLA-DR+ + subset and distinction between direct and indirect effects of IL-4. Exp. Hematol. 21, 635-639.
    • (1993) Exp. Hematol. , vol.21 , pp. 635-639
    • Snoeck, H.W.1    Lardon, F.2    Van Bockstaele, D.R.3    Peetermans, M.E.4
  • 17
    • 0027417459 scopus 로고
    • Interferon-γ and interleukin-4 reciprocally regulate the production of monocytes/macrophages and neutrophils through a direct effect on committed monopotential bone marrow progenitor cells
    • Snoeck, H. W., Lardon, F., Lenjou, M., Nys, G., Van Bockstaele, D. R., Peetermans, M. E. (1993) Interferon-γ and interleukin-4 reciprocally regulate the production of monocytes/macrophages and neutrophils through a direct effect on committed monopotential bone marrow progenitor cells. Eur. J. Immunol. 23, 1072-1077.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1072-1077
    • Snoeck, H.W.1    Lardon, F.2    Lenjou, M.3    Nys, G.4    Van Bockstaele, D.R.5    Peetermans, M.E.6
  • 18
    • 0031948848 scopus 로고    scopus 로고
    • Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression
    • Kaplan, M. H., Daniel, C., Schindler, U., Grusby, M. J. (1998) Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol. Cell. Biol. 18, 1996-2003.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1996-2003
    • Kaplan, M.H.1    Daniel, C.2    Schindler, U.3    Grusby, M.J.4
  • 19
    • 0034544617 scopus 로고    scopus 로고
    • Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1
    • Zhang, S., Lawless, V. A., Kaplan, M. H. (2000) Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1. J. Immunol. 165, 6270-6277.
    • (2000) J. Immunol. , vol.165 , pp. 6270-6277
    • Zhang, S.1    Lawless, V.A.2    Kaplan, M.H.3
  • 20
    • 0042524094 scopus 로고    scopus 로고
    • Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines
    • Kaplan, M. H., Chang, H. C., Cooper, S., Lee, Y., Broxmeyer, H. E. (2003) Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines. J. Hematother. Stem Cell Res. 12, 401-408.
    • (2003) J. Hematother. Stem Cell Res. , vol.12 , pp. 401-408
    • Kaplan, M.H.1    Chang, H.C.2    Cooper, S.3    Lee, Y.4    Broxmeyer, H.E.5
  • 23
    • 0142214644 scopus 로고    scopus 로고
    • Targeted disruption of oncostatin M receptor results in altered hematopoiesis
    • Tanaka, M., Hirabayashi, Y., Sekiguchi, T., Inoue, T., Katsuki, M., Miyajima, A. (2003) Targeted disruption of oncostatin M receptor results in altered hematopoiesis. Blood 102, 3154-3162.
    • (2003) Blood , vol.102 , pp. 3154-3162
    • Tanaka, M.1    Hirabayashi, Y.2    Sekiguchi, T.3    Inoue, T.4    Katsuki, M.5    Miyajima, A.6
  • 24
    • 0037131389 scopus 로고    scopus 로고
    • "Stemness": Transcriptional profiling of embryonic and adult stem cells
    • Ramalho-Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., Melton, D. A. (2002) "Stemness": transcriptional profiling of embryonic and adult stem cells. Science 298, 597-600.
    • (2002) Science , vol.298 , pp. 597-600
    • Ramalho-Santos, M.1    Yoon, S.2    Matsuzaki, Y.3    Mulligan, R.C.4    Melton, D.A.5
  • 26
    • 0024388891 scopus 로고
    • An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse
    • Ploemacher, R. E., van der Sluijs, J. P., Voerman, J. S., Brons, N. H. (1989) An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood 74, 2755-2763.
    • (1989) Blood , vol.74 , pp. 2755-2763
    • Ploemacher, R.E.1    Van Der Sluijs, J.P.2    Voerman, J.S.3    Brons, N.H.4
  • 27
    • 0031708674 scopus 로고    scopus 로고
    • Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells
    • Qu, C. K., Yu, W. M., Azzarelli, B., Cooper, S., Broxmeyer, H. E., Feng, G. S. (1998) Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol. Cell. Biol. 18, 6075-6082.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6075-6082
    • Qu, C.K.1    Yu, W.M.2    Azzarelli, B.3    Cooper, S.4    Broxmeyer, H.E.5    Feng, G.S.6
  • 28
    • 0141730311 scopus 로고    scopus 로고
    • Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling
    • Yu, W. M., Hawley, T. S., Hawley, R. G., Qu, C. K. (2003) Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling. Oncogene 22, 5995-6004.
    • (2003) Oncogene , vol.22 , pp. 5995-6004
    • Yu, W.M.1    Hawley, T.S.2    Hawley, R.G.3    Qu, C.K.4
  • 29
    • 0036081059 scopus 로고    scopus 로고
    • Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S
    • Na, N. T., Traver, D., Weissman, I. L., Akashi, K. (2002) Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J. Clin. Invest. 109, 1579-1585.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1579-1585
    • Na, N.T.1    Traver, D.2    Weissman, I.L.3    Akashi, K.4
  • 30
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    • Chitnis, T., Najafian, N., Benou, C., Salama, A. D., Grusby, M. J., Sayegh, M. H., Khoury, S. J. (2001) Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 108, 739-747.
    • (2001) J. Clin. Invest. , vol.108 , pp. 739-747
    • Chitnis, T.1    Najafian, N.2    Benou, C.3    Salama, A.D.4    Grusby, M.J.5    Sayegh, M.H.6    Khoury, S.J.7
  • 32
    • 0035911232 scopus 로고    scopus 로고
    • Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis
    • Matsukawa, A., Kaplan, M. H., Hogaboam, C. M., Lukacs, N. W., Kunkel, S. L. (2001) Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. J. Exp. Med. 193, 679-688.
    • (2001) J. Exp. Med. , vol.193 , pp. 679-688
    • Matsukawa, A.1    Kaplan, M.H.2    Hogaboam, C.M.3    Lukacs, N.W.4    Kunkel, S.L.5
  • 33
    • 3442886659 scopus 로고    scopus 로고
    • Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFα and IFNγ
    • Zhang, W. J., Koltun, W. A., Thompson, J. L., Tilberg, A. F., Galka, E., Poritz, L. S., Chorney, M. J. (2004) Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFα and IFNγ. Int. J. Oncol. 24, 447-453.
    • (2004) Int. J. Oncol. , vol.24 , pp. 447-453
    • Zhang, W.J.1    Koltun, W.A.2    Thompson, J.L.3    Tilberg, A.F.4    Galka, E.5    Poritz, L.S.6    Chorney, M.J.7
  • 34
    • 0032540279 scopus 로고    scopus 로고
    • A role for the insulin-interleukin (IL)-4 receptor motif of the IL-4 receptor α-chain in regulating activation of the insulin receptor substrate 2 and signal transducer and activator of transcription 6 pathways. Analysis by mutagenesis
    • Wang, H. Y., Zamorano, J., Keegan, A. D. (1998) A role for the insulin-interleukin (IL)-4 receptor motif of the IL-4 receptor α-chain in regulating activation of the insulin receptor substrate 2 and signal transducer and activator of transcription 6 pathways. Analysis by mutagenesis. J. Biol. Chem. 273, 9898-9905.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9898-9905
    • Wang, H.Y.1    Zamorano, J.2    Keegan, A.D.3
  • 35
    • 0023124410 scopus 로고
    • Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage
    • Ohara, J., Paul, W. E. (1987) Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature 325, 537-540.
    • (1987) Nature , vol.325 , pp. 537-540
    • Ohara, J.1    Paul, W.E.2
  • 36
    • 0023243624 scopus 로고
    • Effects of B cell stimulatory factor-1/interleukin 4 on hematopoietic progenitor cells
    • Peschel, C., Paul, W. E., Ohara, J., Green, I. (1987) Effects of B cell stimulatory factor-1/interleukin 4 on hematopoietic progenitor cells. Blood 70, 254-263.
    • (1987) Blood , vol.70 , pp. 254-263
    • Peschel, C.1    Paul, W.E.2    Ohara, J.3    Green, I.4
  • 37
    • 0024160860 scopus 로고
    • Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. Multiple actions
    • Broxmeyer, H. E., Lu, L., Cooper, S., Tushinski, R., Mochizuki, D., Rubin, B. Y., Gillis, S., Williams, D. E. (1988) Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. Multiple actions. J. Immunol. 141, 3852-3862.
    • (1988) J. Immunol. , vol.141 , pp. 3852-3862
    • Broxmeyer, H.E.1    Lu, L.2    Cooper, S.3    Tushinski, R.4    Mochizuki, D.5    Rubin, B.Y.6    Gillis, S.7    Williams, D.E.8
  • 38
    • 0025942679 scopus 로고
    • Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice
    • Musashi, M., Clark, S. C., Sudo, T., Urdal, D. L., Ogawa, M. (1991) Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice. Blood 78, 1448-1451.
    • (1991) Blood , vol.78 , pp. 1448-1451
    • Musashi, M.1    Clark, S.C.2    Sudo, T.3    Urdal, D.L.4    Ogawa, M.5
  • 39
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle, H., Holtschke, T., Hunig, T., Schimpl, A., Horak, I. (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352, 621-624.
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 41
    • 0342632839 scopus 로고    scopus 로고
    • Normal regulatory α/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo
    • Suzuki, H., Zhou, Y. W., Kato, M., Mak, T. W., Nakashima, I. (1999) Normal regulatory α/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo. J. Exp. Med. 190, 1561-1572.
    • (1999) J. Exp. Med. , vol.190 , pp. 1561-1572
    • Suzuki, H.1    Zhou, Y.W.2    Kato, M.3    Mak, T.W.4    Nakashima, I.5
  • 42
    • 0036965726 scopus 로고    scopus 로고
    • Hematopoietic stem cell functional failure in interleukin-2-deficient mice
    • Chen, J., Astle, C. M., Harrison, D. E. (2002) Hematopoietic stem cell functional failure in interleukin-2-deficient mice. J. Hematother. Stem Cell Res. 11, 905-912.
    • (2002) J. Hematother. Stem Cell Res. , vol.11 , pp. 905-912
    • Chen, J.1    Astle, C.M.2    Harrison, D.E.3


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