Bystander responses in three-dimensional cultures containing radiolabelled and unlabelled human cells

Radiation Protection Dosimetry

Volumn 122, Issue 1-4, 2006, Pages 252-255

  Pinto, M ^a   Azzam, E I ^a   Howell, R W ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CARBON; DEOXYCYTIDINE; DNA; IDOXURIDINE; MONOCLONAL ANTIBODY; PROPIDIUM IODIDE; TRITIUM; RADIOACTIVE IODINE;

ARTICLE; BYSTANDER EFFECT; CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL LABELING; CELL PROLIFERATION; CONTROLLED STUDY; DIPLOIDY; ELECTRON; FIBROBLAST CULTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEDICAL RESEARCH; PHASE TRANSITION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; THREE DIMENSIONAL IMAGING; TIME; BIOLOGICAL MODEL; CELL CYCLE; CELL LINE; CELL SURVIVAL; CULTURE TECHNIQUE; DNA DAMAGE; FIBROBLAST; ISOTOPE LABELING; METHODOLOGY; PHYSIOLOGY; RADIATION RESPONSE;

BYSTANDER EFFECT; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL LINE; CELL SURVIVAL; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; HUMANS; IODINE RADIOISOTOPES; ISOTOPE LABELING; MODELS, BIOLOGICAL; RADIATION DOSAGE; RADIATION TOLERANCE;

EID: 34347407625     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/rpd/ncl460     Document Type: Article

References (11)

1. Mothersill, C. and Seymour, C. Radiation-induced bystander effects: past history and future directions. Radiat. Res. 155(6), 759-767 (2001).
2. Azzam, E. I. and Little, J. B. The radiation-induced bystander effect: Evidence and significance. Hum. Exp. Toxicol. 23(2), 61-65 (2004).
3. Azzam, E. I., de Toledo, S. M. and Little, J. B. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl Acad. Sci. USA 98(2), 473-478 (2001).
4. Bishayee, A., Rao, D. V. and Howell, R.W. Evidence for pronounced bystander effects caused by nonuniform distributions of radioactivity using a novel three-dimensional tissue culture model. Radiat. Res. 152(1), 88-97 (1999).
5. 1 checkpoint in human diploid fibroblasts. Cancer Res. 60(10), 2623-2631 (2000).
6. Bishayee, A., Hill, H. Z., Stein, D., Rao, D. V. and Howell, R. W. Free radical-initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat. Res. 155(2), 335-344 (2001).
7. Goddu, S. M., Howell, R. W., Bouchet, L. G., Bolch, W. E. and Rao, D. V. MIRD Cellular S Values: Self-absorbed Dose Per Unit Cumulated Activity for Selected Radionuclides and Monoenergetic Electron and Alpha Particle Emitters Incorporated into Different Cell Compartments. (Reston, VA: Society of Nuclear Medicine) (1997).
8. Gerashchenko, B. I. and Howell, R.W. Proliferative response of bystander cells adjacent to cells with incorporated radioactivity. Cytometry A 60(2), 155-164 (2004).
9. Gerashchenko, B. I. and Howell, R.W. Bystander cell proliferation is modulated by the number of adjacent cells that were exposed to ionizing radiation. Cytometry A 66(1), 62-70 (2005).
10. Persaud, R., Zhou, H., Baker, S. E., Hei, T. K. and Hall, E.J. Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Res. 65 21), 9876-9882 (2005).
11. Barcellos-Hoff, M. H. and Brooks, A. L. Extracellular signaling through the microenvironment a hypothesis relating carcinogenesis, bystander effects, and genomic instability. Radiat. Res. 156(5 Pt 2), 618-627 (2001).